ID A5E2V0_LODEL Unreviewed; 620 AA.
AC A5E2V0;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 08-NOV-2023, entry version 80.
DE RecName: Full=Origin recognition complex subunit 4 {ECO:0000256|ARBA:ARBA00019083};
GN ORFNames=LELG_03937 {ECO:0000313|EMBL:EDK45758.1};
OS Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC Lodderomyces.
OX NCBI_TaxID=379508 {ECO:0000313|EMBL:EDK45758.1, ECO:0000313|Proteomes:UP000001996};
RN [1] {ECO:0000313|EMBL:EDK45758.1, ECO:0000313|Proteomes:UP000001996}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 /
RC NRRL YB-4239 {ECO:0000313|Proteomes:UP000001996};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ORC4 family.
CC {ECO:0000256|ARBA:ARBA00005334}.
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DR EMBL; CH981528; EDK45758.1; -; Genomic_DNA.
DR RefSeq; XP_001524905.1; XM_001524855.1.
DR AlphaFoldDB; A5E2V0; -.
DR STRING; 379508.A5E2V0; -.
DR GeneID; 5231834; -.
DR KEGG; lel:LELG_03937; -.
DR VEuPathDB; FungiDB:LELG_03937; -.
DR eggNOG; KOG2228; Eukaryota.
DR HOGENOM; CLU_007115_4_1_1; -.
DR InParanoid; A5E2V0; -.
DR OMA; QRIIYMP; -.
DR OrthoDB; 230201at2759; -.
DR Proteomes; UP000001996; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000808; C:origin recognition complex; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR016527; ORC4.
DR InterPro; IPR032705; ORC4_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12087; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR12087:SF0; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF14629; ORC4_C; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001996}.
FT DOMAIN 197..372
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 620 AA; 69611 MW; E93851712ABFFE5F CRC64;
MNVPQDLDRR KNDDNNNNNN NNNNSNDRGT DTGTGNGTEL NPMHRLPDSE VAKASHKRKY
SHSPGDSYGG PEVIPALEPE AELELRSKSY TELNSELNQL DGKPVENGKL EKGKRIKLLA
VPHSETQTTA TPNKTFDRTL KKTSDINGSN CCDDIQRIIQ RVMLQLNGEL DLRGNSSLKE
IYSTIYNVFF KAVIQKESHS ILLVGPKGCG KSTIVEQALT SLDKIAPDAY IRINLHSSIH
TDDREALREV ARQLDRSFSD FSGSKGNFTE KVLEQKSIND TLANILQVLG GTSSGSESTE
RQWIPLVFII DEIEKFATSN RQTLLYNLLD LCQNSQVPIS VIGLTSKLNA KESLEKRVSS
RFSQRTETIV FPHSFEEFVA NAKLHLLLGD EYINLLELPK LGLEWNEQIE RVFGDKTSKL
AEFHMREYHT TRNYRVILDQ YKIALSGVSM LSGVHKTKDV NALGLLTLNA NFASRTGSVI
REILLSLSTV ELFILIAAVR WLEKYDADVI NFSLAFLEYI QMQKLTEPTN SFSSGLTTSI
QVEKRLWTRE LLRNSWRNLY RVGILVDPQT TGGDVSHGGD SRSSSTVLEE NTMVVIDITL
DELSAFVLKK PGLKKYLRLS
//
