ID A5E3T1_LODEL Unreviewed; 514 AA.
AC A5E3T1;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=choline-phosphate cytidylyltransferase {ECO:0000256|ARBA:ARBA00026101};
DE EC=2.7.7.15 {ECO:0000256|ARBA:ARBA00026101};
GN ORFNames=LELG_04269 {ECO:0000313|EMBL:EDK46089.1};
OS Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC Lodderomyces.
OX NCBI_TaxID=379508 {ECO:0000313|EMBL:EDK46089.1, ECO:0000313|Proteomes:UP000001996};
RN [1] {ECO:0000313|EMBL:EDK46089.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NRRL YB-4239 {ECO:0000313|EMBL:EDK46089.1};
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Cuomo C., Jaffe D.,
RA Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.,
RA Brockman W., MacCallum I.A., Rounsley S., Young S., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Kodira C., Zeng Q., Yandava C., Alvarado L., O'leary S., Kurtzman C.,
RA Reedy J., Heitman J.;
RT "The genome sequence of Lodderomyces elongisporus.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EDK46089.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL YB-4239 {ECO:0000313|EMBL:EDK46089.1};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SIMILARITY: Belongs to the cytidylyltransferase family.
CC {ECO:0000256|ARBA:ARBA00010101}.
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DR EMBL; CH981529; EDK46089.1; -; Genomic_DNA.
DR RefSeq; XP_001524298.1; XM_001524248.1.
DR AlphaFoldDB; A5E3T1; -.
DR STRING; 379508.A5E3T1; -.
DR GeneID; 5231605; -.
DR KEGG; lel:LELG_04269; -.
DR VEuPathDB; FungiDB:LELG_04269; -.
DR eggNOG; KOG2804; Eukaryota.
DR HOGENOM; CLU_034585_0_1_1; -.
DR InParanoid; A5E3T1; -.
DR OMA; KWIHGED; -.
DR OrthoDB; 5474784at2759; -.
DR Proteomes; UP000001996; Unassembled WGS sequence.
DR GO; GO:0004105; F:choline-phosphate cytidylyltransferase activity; IEA:InterPro.
DR CDD; cd02174; CCT; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR041723; CCT.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR045049; Pcy1-like.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00125; cyt_tran_rel; 1.
DR PANTHER; PTHR10739:SF13; CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE; 1.
DR PANTHER; PTHR10739; CYTIDYLYLTRANSFERASE; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000001996}.
FT DOMAIN 154..281
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 35..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..90
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 514 AA; 59357 MW; 8085E5C551F26684 CRC64;
MARLPRRKAI ENELNGHGAP LTRTLSIESI SSLFKRNRKR KLEDDSSVKS SSPTTDNEDA
ELSKYEDEVE ENDDDDDDDD NEEEEEDKDK DGNDQEGRGG NRRAKKRRIK TKEEEEFEEK
ERKLDEELPE EYRKFRPRGF RFNIPPKDKP IRIYADGVFD LFHLGHMKQL EQAKKSFENV
ELVCGIPSDK ETHKRKGLTV LTDEQRCETL KHCKWVDEVI PNAPWCVTPE FLREHNIDYV
AHDDLPYASS DSDDIYKPIK EQGMFLTTQR TEGISTSDII TKIIRDYDKY LMRNFARGAT
RKELNVSWLK KNELEFKKHI NDFRTYWMRN KLNINNVSRD LYFEIREFMR GKKFDVQQYL
ENQQKQQQKH KNQQLITNGS QGPSRSGSIS DFEDSTSYKG GSPLTDFASK YIGNANKELN
NAGKVILKWI HGEDDSDEEE IKPIVIKPVH KARRRSSSSS SSIKPRLINN SATTNANTNA
TTTTTKGTLS GAAVKSTPKK GSSTPRKTPQ KKAY
//
