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Database: UniProt
Entry: A5E8J8
LinkDB: A5E8J8
Original site: A5E8J8 
ID   PYRF_BRASB              Reviewed;         243 AA.
AC   A5E8J8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   14-MAY-2014, entry version 43.
DE   RecName: Full=Orotidine 5'-phosphate decarboxylase;
DE            EC=4.1.1.23;
DE   AltName: Full=OMP decarboxylase;
DE            Short=OMPDCase;
DE            Short=OMPdecase;
GN   Name=pyrF; OrderedLocusNames=BBta_0195;
OS   Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium.
OX   NCBI_TaxID=288000;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BTAi1 / ATCC BAA-1182;
RX   PubMed=17540897; DOI=10.1126/science.1139548;
RA   Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.-C.,
RA   Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L.,
RA   Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S.,
RA   Rouy Z., Mangenot S., Segurens B., Dossat C., Franck W.L.,
RA   Chang W.-S., Saunders E., Bruce D., Richardson P., Normand P.,
RA   Dreyfus B., Pignol D., Stacey G., Emerich D., Vermeglio A.,
RA   Medigue C., Sadowsky M.;
RT   "Legumes symbioses: absence of nod genes in photosynthetic
RT   bradyrhizobia.";
RL   Science 316:1307-1312(2007).
CC   -!- FUNCTION: Catalyzes the decarboxylation of orotidine 5'-
CC       monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Orotidine 5'-phosphate = UMP + CO(2).
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; UMP from orotate: step 2/2.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the OMP decarboxylase family. Type 1
CC       subfamily.
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DR   EMBL; CP000494; ABQ32492.1; -; Genomic_DNA.
DR   RefSeq; YP_001236398.1; NC_009485.1.
DR   ProteinModelPortal; A5E8J8; -.
DR   STRING; 288000.BBta_0195; -.
DR   EnsemblBacteria; ABQ32492; ABQ32492; BBta_0195.
DR   GeneID; 5150940; -.
DR   KEGG; bbt:BBta_0195; -.
DR   PATRIC; 21201390; VBIBraSp29847_0399.
DR   eggNOG; COG0284; -.
DR   HOGENOM; HOG000226070; -.
DR   KO; K01591; -.
DR   OMA; RPITQSA; -.
DR   OrthoDB; EOG6N6815; -.
DR   BioCyc; BSP288000:GJBR-188-MONOMER; -.
DR   UniPathway; UPA00070; UER00120.
DR   GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_01200_B; OMPdecase_type1_B; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR014732; OMPdecase.
DR   InterPro; IPR018089; OMPdecase_AS.
DR   InterPro; IPR001754; OMPdeCOase_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   Pfam; PF00215; OMPdecase; 1.
DR   SMART; SM00934; OMPdecase; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   TIGRFAMs; TIGR01740; pyrF; 1.
DR   PROSITE; PS00156; OMPDECASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Decarboxylase; Lyase; Pyrimidine biosynthesis.
FT   CHAIN         1    243       Orotidine 5'-phosphate decarboxylase.
FT                                /FTId=PRO_1000065895.
FT   REGION       65     74       Substrate binding (By similarity).
FT   ACT_SITE     67     67       Proton donor (By similarity).
FT   BINDING      16     16       Substrate (By similarity).
FT   BINDING      38     38       Substrate (By similarity).
FT   BINDING     120    120       Substrate (By similarity).
FT   BINDING     181    181       Substrate (By similarity).
FT   BINDING     190    190       Substrate (By similarity).
FT   BINDING     210    210       Substrate; via amide nitrogen (By
FT                                similarity).
FT   BINDING     211    211       Substrate (By similarity).
SQ   SEQUENCE   243 AA;  25201 MW;  895A0F455256A1FE CRC64;
     MPTEIAPRDR LIVALDLPGV AEAEAMITRL GDAVTFYKIG MELTYAGGLG LAERLAADGK
     QVFMDLKLHD IPNTVERATR QIARLGARFL TVHGFSQSMT AALAGAAGSP LELLAVTVMT
     SYDDADLAAA GYAMGVKELV ARRAVQAKQI GIHGLILSPE ETQLVRPLVG PDMQLVTPGI
     RPAGSDVGDQ KRIMTPALAI AGGADRLVVG RPVTGAADPA AAAESIVADI ASALALVGKT
     NRT
//
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