ID UBIA_VIBC3 Reviewed; 284 AA.
AC A5F4H4; C3M2F0;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 01-MAY-2013, entry version 48.
DE RecName: Full=4-hydroxybenzoate octaprenyltransferase;
DE EC=2.5.1.-;
DE AltName: Full=4-HB polyprenyltransferase;
GN Name=ubiA; OrderedLocusNames=VC0395_A2421, VC395_0086;
OS Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales;
OC Vibrionaceae; Vibrio.
OX NCBI_TaxID=345073;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39541 / Ogawa 395 / O395;
RA Heidelberg J.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39541 / Ogawa 395 / O395;
RX PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y.,
RA Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.;
RT "A recalibrated molecular clock and independent origins for the
RT cholera pandemic clones.";
RL PLoS ONE 3:E4053-E4053(2008).
CC -!- FUNCTION: Synthesis of 3-octaprenyl-4-hydroxybenzoate (By
CC similarity).
CC -!- CATALYTIC ACTIVITY: 4-hydroxybenzoate + farnesylfarnesylgeraniol =
CC 3-octaprenyl-4-hydroxybenzoate.
CC -!- COFACTOR: Magnesium (By similarity).
CC -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC protein (By similarity).
CC -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
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DR EMBL; CP000627; ABQ20837.1; -; Genomic_DNA.
DR EMBL; CP001235; ACP08114.1; -; Genomic_DNA.
DR RefSeq; YP_001218321.1; NC_009457.1.
DR RefSeq; YP_002818350.1; NC_012582.1.
DR STRING; 345073.VC0395_A2421; -.
DR EnsemblBacteria; ABQ20837; ABQ20837; VC0395_A2421.
DR EnsemblBacteria; ACP08114; ACP08114; VC395_0086.
DR GeneID; 5135408; -.
DR GeneID; 7774189; -.
DR KEGG; vco:VC0395_A2421; -.
DR KEGG; vcr:VC395_0086; -.
DR eggNOG; COG0382; -.
DR HOGENOM; HOG000003696; -.
DR KO; K03179; -.
DR OMA; YHYTLIR; -.
DR ProtClustDB; PRK12848; -.
DR UniPathway; UPA00232; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008412; F:4-hydroxybenzoate octaprenyltransferase activity; IEA:HAMAP.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_01635; UbiA; 1; -.
DR InterPro; IPR006370; HB_polyprenyl-transferase.
DR InterPro; IPR000537; UbiA_prenyltransferase.
DR Pfam; PF01040; UbiA; 1.
DR TIGRFAMs; TIGR01474; ubiA_proteo; 1.
DR PROSITE; PS00943; UBIA; FALSE_NEG.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Complete proteome; Magnesium;
KW Membrane; Transferase; Transmembrane; Transmembrane helix;
KW Ubiquinone biosynthesis.
FT CHAIN 1 284 4-hydroxybenzoate octaprenyltransferase.
FT /FTId=PRO_1000073654.
FT TRANSMEM 19 39 Helical; (Potential).
FT TRANSMEM 42 62 Helical; (Potential).
FT TRANSMEM 93 113 Helical; (Potential).
FT TRANSMEM 114 134 Helical; (Potential).
FT TRANSMEM 136 156 Helical; (Potential).
FT TRANSMEM 158 178 Helical; (Potential).
FT TRANSMEM 210 230 Helical; (Potential).
FT TRANSMEM 233 253 Helical; (Potential).
FT TRANSMEM 264 284 Helical; (Potential).
SQ SEQUENCE 284 AA; 31820 MW; 4F9697774C36CAC6 CRC64;
MTAVKARAYW QLMRMDRPIG SLLLLWPTLW ALLLAAQGLP DLRVLVVFVL GVFLMRSAGC
VINDYADRHV DGHVKRTSQR PLPAGLVSAK EALLLFVLLA VSSFLLVLTM NTLTIQLSFI
GILLAFVYPF MKRFTHLPQL VLGLAFSWSI PMAWAAQANT LTPQVWVLFL INALWTIAYD
TQYAMVDRDD DVKIGIKSTA ILFGRWDKRI IGLLQLATLS LLVALGQGLA LGTSYYWGLL
IAAGLFAYQQ HLIRYRERMP CFQAFLNNNY VGMAITAGIL LSVW
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