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Database: UniProt
Entry: A5F4H4
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Original site: A5F4H4 
ID   UBIA_VIBC3              Reviewed;         284 AA.
AC   A5F4H4; C3M2F0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   29-OCT-2014, entry version 55.
DE   RecName: Full=4-hydroxybenzoate octaprenyltransferase {ECO:0000255|HAMAP-Rule:MF_01635};
DE            EC=2.5.1.- {ECO:0000255|HAMAP-Rule:MF_01635};
DE   AltName: Full=4-HB polyprenyltransferase {ECO:0000255|HAMAP-Rule:MF_01635};
GN   Name=ubiA {ECO:0000255|HAMAP-Rule:MF_01635};
GN   OrderedLocusNames=VC0395_A2421, VC395_0086;
OS   Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /
OS   O395).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales;
OC   Vibrionaceae; Vibrio.
OX   NCBI_TaxID=345073;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RA   Heidelberg J.;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RX   PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA   Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y.,
RA   Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.;
RT   "A recalibrated molecular clock and independent origins for the
RT   cholera pandemic clones.";
RL   PLoS ONE 3:E4053-E4053(2008).
CC   -!- FUNCTION: Synthesis of 3-octaprenyl-4-hydroxybenzoate.
CC       {ECO:0000255|HAMAP-Rule:MF_01635}.
CC   -!- CATALYTIC ACTIVITY: 4-hydroxybenzoate + farnesylfarnesylgeraniol =
CC       3-octaprenyl-4-hydroxybenzoate. {ECO:0000255|HAMAP-Rule:MF_01635}.
CC   -!- COFACTOR: Magnesium. {ECO:0000255|HAMAP-Rule:MF_01635}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01635}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01635}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01635}.
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01635}.
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DR   EMBL; CP000627; ABQ20837.1; -; Genomic_DNA.
DR   EMBL; CP001235; ACP08114.1; -; Genomic_DNA.
DR   RefSeq; YP_001218321.1; NC_009457.1.
DR   RefSeq; YP_002818350.1; NC_012582.1.
DR   STRING; 345073.VC0395_A2421; -.
DR   EnsemblBacteria; ABQ20837; ABQ20837; VC0395_A2421.
DR   EnsemblBacteria; ACP08114; ACP08114; VC395_0086.
DR   GeneID; 5135408; -.
DR   GeneID; 7774189; -.
DR   KEGG; vco:VC0395_A2421; -.
DR   KEGG; vcr:VC395_0086; -.
DR   eggNOG; COG0382; -.
DR   HOGENOM; HOG000003696; -.
DR   KO; K03179; -.
DR   OMA; GMPMAFT; -.
DR   UniPathway; UPA00232; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004659; F:prenyltransferase activity; IEA:InterPro.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_01635; UbiA; 1.
DR   InterPro; IPR006370; HB_polyprenyl-transferase.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   Pfam; PF01040; UbiA; 1.
DR   TIGRFAMs; TIGR01474; ubiA_proteo; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Complete proteome; Magnesium;
KW   Membrane; Transferase; Transmembrane; Transmembrane helix;
KW   Ubiquinone biosynthesis.
FT   CHAIN         1    284       4-hydroxybenzoate octaprenyltransferase.
FT                                /FTId=PRO_1000073654.
FT   TRANSMEM     19     39       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01635}.
FT   TRANSMEM     42     62       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01635}.
FT   TRANSMEM     93    113       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01635}.
FT   TRANSMEM    114    134       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01635}.
FT   TRANSMEM    136    156       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01635}.
FT   TRANSMEM    158    178       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01635}.
FT   TRANSMEM    210    230       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01635}.
FT   TRANSMEM    233    253       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01635}.
FT   TRANSMEM    264    284       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01635}.
SQ   SEQUENCE   284 AA;  31820 MW;  4F9697774C36CAC6 CRC64;
     MTAVKARAYW QLMRMDRPIG SLLLLWPTLW ALLLAAQGLP DLRVLVVFVL GVFLMRSAGC
     VINDYADRHV DGHVKRTSQR PLPAGLVSAK EALLLFVLLA VSSFLLVLTM NTLTIQLSFI
     GILLAFVYPF MKRFTHLPQL VLGLAFSWSI PMAWAAQANT LTPQVWVLFL INALWTIAYD
     TQYAMVDRDD DVKIGIKSTA ILFGRWDKRI IGLLQLATLS LLVALGQGLA LGTSYYWGLL
     IAAGLFAYQQ HLIRYRERMP CFQAFLNNNY VGMAITAGIL LSVW
//
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