ID PYRB_ACICJ Reviewed; 311 AA.
AC A5FWH1;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 01-MAY-2013, entry version 43.
DE RecName: Full=Aspartate carbamoyltransferase;
DE EC=2.1.3.2;
DE AltName: Full=Aspartate transcarbamylase;
DE Short=ATCase;
GN Name=pyrB; OrderedLocusNames=Acry_0733;
OS Acidiphilium cryptum (strain JF-5).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC Acetobacteraceae; Acidiphilium.
OX NCBI_TaxID=349163;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JF-5;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Magnuson T.,
RA Richardson P.;
RT "Complete sequence of chromosome of Acidiphilium cryptum JF-5.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate
CC + N-carbamoyl-L-aspartate.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC pathway; (S)-dihydroorotate from bicarbonate: step 2/3.
CC -!- SIMILARITY: Belongs to the ATCase/OTCase family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; CP000697; ABQ29953.1; -; Genomic_DNA.
DR RefSeq; YP_001233872.1; NC_009484.1.
DR ProteinModelPortal; A5FWH1; -.
DR STRING; 349163.Acry_0733; -.
DR EnsemblBacteria; ABQ29953; ABQ29953; Acry_0733.
DR GeneID; 5162211; -.
DR KEGG; acr:Acry_0733; -.
DR PATRIC; 20646444; VBIAciCry6074_1221.
DR eggNOG; COG0540; -.
DR HOGENOM; HOG000022685; -.
DR KO; K00609; -.
DR OMA; MTLNAMR; -.
DR ProtClustDB; PRK00856; -.
DR BioCyc; ACRY349163:GHET-788-MONOMER; -.
DR UniPathway; UPA00070; UER00116.
DR GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:HAMAP.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
DR HAMAP; MF_00001; Asp_carb_tr; 1; -.
DR InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR InterPro; IPR002082; Asp_carbamoyltransf.
DR InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR Pfam; PF00185; OTCace; 1.
DR Pfam; PF02729; OTCace_N; 1.
DR PRINTS; PR00100; AOTCASE.
DR PRINTS; PR00101; ATCASE.
DR SUPFAM; SSF53671; Asp/Orn_carbamoyltranf; 1.
DR TIGRFAMs; TIGR00670; asp_carb_tr; 1.
DR PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE 3: Inferred from homology;
KW Complete proteome; Pyrimidine biosynthesis; Transferase.
FT CHAIN 1 311 Aspartate carbamoyltransferase.
FT /FTId=PRO_0000321059.
SQ SEQUENCE 311 AA; 33475 MW; 16FFB92DF2154AE2 CRC64;
MRLPTRHLLG IEGLHPRDIS ALLDLAESYV LLNRSGKTRR DVLRGRTLIN LFFEDSTRTR
TSFELAGKRL GADVINMSVS TSSVSKGETL LDTAATLNAM NCDLLVVRHK ASGAPALLAQ
KVDAAVINAG DGMHEHPTQA LLDALTIRRN KGTLAGLTVA ICGDIAHSRV ARSNLLLLTA
MGSRVRVVGP PTLIPSGIDQ FGATVFHDMR EGLRDADIVM ALRLQTERMS AGLIPSAREF
FTFYGLDAAK LAMAKPDALV MHPGPMNRGV EIDSQVADDA TRSVIREQVE MGVAIRMAVL
DVLARTALAH A
//
