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Database: UniProt
Entry: A5G8T2
LinkDB: A5G8T2
Original site: A5G8T2 
ID   HIS7_GEOUR              Reviewed;         195 AA.
AC   A5G8T2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   19-FEB-2014, entry version 47.
DE   RecName: Full=Imidazoleglycerol-phosphate dehydratase;
DE            Short=IGPD;
DE            EC=4.2.1.19;
GN   Name=hisB; OrderedLocusNames=Gura_4056;
OS   Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC   Geobacteraceae; Geobacter.
OX   NCBI_TaxID=351605;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rf4;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Shelobolina E., Aklujkar M., Lovley D., Richardson P.;
RT   "Complete sequence of Geobacter uraniireducens Rf4.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: D-erythro-1-(imidazol-4-yl)glycerol 3-
CC       phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the imidazoleglycerol-phosphate dehydratase
CC       family.
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DR   EMBL; CP000698; ABQ28200.1; -; Genomic_DNA.
DR   RefSeq; YP_001232773.1; NC_009483.1.
DR   ProteinModelPortal; A5G8T2; -.
DR   SMR; A5G8T2; 2-184.
DR   STRING; 351605.Gura_4056; -.
DR   EnsemblBacteria; ABQ28200; ABQ28200; Gura_4056.
DR   GeneID; 5165554; -.
DR   KEGG; gur:Gura_4056; -.
DR   PATRIC; 22038557; VBIGeoUra13052_4325.
DR   eggNOG; COG0131; -.
DR   HOGENOM; HOG000228064; -.
DR   KO; K01693; -.
DR   OMA; HHIAESC; -.
DR   OrthoDB; EOG60PHGP; -.
DR   ProtClustDB; PRK00951; -.
DR   BioCyc; GURA351605:GI6A-4111-MONOMER; -.
DR   UniPathway; UPA00031; UER00011.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004424; F:imidazoleglycerol-phosphate dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_00076; HisB; 1.
DR   InterPro; IPR000807; ImidazoleglycerolP_deHydtase.
DR   InterPro; IPR020565; ImidazoleglycerP_deHydtase_CS.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR23133:SF2; PTHR23133:SF2; 1.
DR   Pfam; PF00475; IGPD; 1.
DR   SUPFAM; SSF54211; SSF54211; 2.
DR   PROSITE; PS00954; IGP_DEHYDRATASE_1; 1.
DR   PROSITE; PS00955; IGP_DEHYDRATASE_2; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm;
KW   Histidine biosynthesis; Lyase.
FT   CHAIN         1    195       Imidazoleglycerol-phosphate dehydratase.
FT                                /FTId=PRO_1000075247.
SQ   SEQUENCE   195 AA;  21598 MW;  B8FF2F35410C8B91 CRC64;
     MSRKAVIERI TKETQIKLSL NIDGSGEARV CTSVPFLDHM LNLFARHGLF DLEVEAKGDI
     DIDFHHTVED IGIVLGEALK QALGDKQGIR RYGQATVPMD ETLASVAVDL SGRPYLVYNV
     RLPKVKIGEF DVELAREFFQ ALTNNLAANL HINVMYGDNV HHILEACFKA LARALDQATQ
     QDPRIAGVMS TKGKL
//
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