ID   A5H4H9_9HIV1            Unreviewed;       219 AA.
AC   A5H4H9;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Reverse transcriptase {ECO:0000313|EMBL:ABN71726.1};
DE   Flags: Fragment;
GN   Name=pol {ECO:0000313|EMBL:ABN71726.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:ABN71726.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:ABN71726.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=1 {ECO:0000313|EMBL:ABN71726.1};
RX   PubMed=17436219; DOI=10.1086/513871;
RG   Pediatric AIDS Clinical Trials Group P1030 Team;
RA   Persaud D., Palumbo P., Ziemniak C., Chen J., Ray S.C., Hughes M.,
RA   Havens P., Purswani M., Gaur A.H., Chadwick E.G.;
RT   "Early archiving and predominance of nonnucleoside reverse transcriptase
RT   inhibitor-resistant HIV-1 among recently infected infants born in the
RT   United States.";
RL   J. Infect. Dis. 195:1402-1410(2007).
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DR   EMBL; EF066768; ABN71726.1; -; Genomic_DNA.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR   PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918,
KW   ECO:0000313|EMBL:ABN71726.1}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW   Virion maturation {ECO:0000256|ARBA:ARBA00023113}.
FT   DOMAIN          27..217
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ABN71726.1"
FT   NON_TER         219
FT                   /evidence="ECO:0000313|EMBL:ABN71726.1"
SQ   SEQUENCE   219 AA;  25463 MW;  25750B012CC90683 CRC64;
     GPKVKQWPLT EEKIKALIKI CSEMEKEGKI SKIGPENPYN TPVFAIKKKD STKWRKLVDF
     RELNKRTQDF WEVQLGIPHP AGLKKKKSVT VLDVGDAYFS VPLDKDFRKY TAFTIPSINN
     ETPGTRYQYN VLPQGWKGSP AIFQSSMTKI LEPFRKKNPD IVIYQYVDDL YVGSDLEIGQ
     HRTKIEELRG HLLKWGFTTP DKKHQKEPPF LWMGYELHP
//