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Database: UniProt
Entry: A5HS35_9HIV1
LinkDB: A5HS35_9HIV1
Original site: A5HS35_9HIV1 
ID   A5HS35_9HIV1            Unreviewed;       343 AA.
AC   A5HS35;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   24-JAN-2024, entry version 95.
DE   SubName: Full=Pol protein {ECO:0000313|EMBL:ABQ16411.1};
DE   Flags: Fragment;
GN   Name=pol {ECO:0000313|EMBL:ABQ16411.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:ABQ16411.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:ABQ16411.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A384-01084 {ECO:0000313|EMBL:ABQ16411.1};
RA   Johnson V.A., Smeaton L.M., Shafer R.W., DeGruttola V., Winters M.,
RA   Hazelwood J.D., Sutton L., Healy B., Snyder S.W., Pettinelli C.,
RA   Hirsch M.S., Merigan T.C., Wantman M., Robbins G.K., D'Aquila R.T.;
RT   "Detection of HIV Drug Resistance at Regimen Failure during Sequential 3-
RT   Drug versus Initial 4-Drug HAART Strategies in AIDS Clinical Trials Group
RT   Protocol 384.";
RL   J. Acquir. Immune Defic. Syndr. 0:0-0(2007).
CC   -!- SIMILARITY: Belongs to the retroviral Pol polyprotein family.
CC       {ECO:0000256|RuleBase:RU004064}.
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DR   EMBL; EF549247; ABQ16411.1; -; Genomic_DNA.
DR   MEROPS; A02.001; -.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR   CDD; cd05482; HIV_retropepsin_like; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001995; Peptidase_A2_cat.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   InterPro; IPR034170; Retropepsin-like_cat_dom.
DR   InterPro; IPR018061; Retropepsins.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR   PANTHER; PTHR41694:SF3; INTEGRASE-RELATED; 1.
DR   Pfam; PF00077; RVP; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50175; ASP_PROT_RETROV; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|ARBA:ARBA00022750,
KW   ECO:0000256|RuleBase:RU004064};
KW   DNA integration {ECO:0000256|ARBA:ARBA00023195};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU004064};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022771};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Protease {ECO:0000256|RuleBase:RU004064};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW   Virus entry into host cell {ECO:0000256|ARBA:ARBA00023195};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          17..86
FT                   /note="Peptidase A2"
FT                   /evidence="ECO:0000259|PROSITE:PS50175"
FT   DOMAIN          140..330
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ABQ16411.1"
FT   NON_TER         343
FT                   /evidence="ECO:0000313|EMBL:ABQ16411.1"
SQ   SEQUENCE   343 AA;  39029 MW;  069F17788FF16628 CRC64;
     TLWQRPLVTV KIGGQLKEAL LDTGADDTVL EEMNLPGRWK PKMIGGIGGF IKVRQYDQVP
     IEICGHKAIG TVLVGPTPVN IIGRNLLTQI GCTLNFXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXCTEMEKE GKISKIGPEN PYNTPVFAIK KKDSTKWRKL VDFRELNKXT
     QDFWEVQLGI PHPAGLXKXK SXTVLDVGDA YFSVPLDXXF RKYTAFTIPS INNETPGIRY
     QYNVLPQGWK GSPAIFQSSM TKILEPFRKQ NPEIVIYQYM DDLYVGSDLE IGQHRTKIEE
     LRQHLLXWGF TTPDKKHQKE PPFLWMGYEL HPDKWTVQPI XLP
//
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