ID A5HS35_9HIV1 Unreviewed; 343 AA.
AC A5HS35;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 24-JAN-2024, entry version 95.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:ABQ16411.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:ABQ16411.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ABQ16411.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ABQ16411.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A384-01084 {ECO:0000313|EMBL:ABQ16411.1};
RA Johnson V.A., Smeaton L.M., Shafer R.W., DeGruttola V., Winters M.,
RA Hazelwood J.D., Sutton L., Healy B., Snyder S.W., Pettinelli C.,
RA Hirsch M.S., Merigan T.C., Wantman M., Robbins G.K., D'Aquila R.T.;
RT "Detection of HIV Drug Resistance at Regimen Failure during Sequential 3-
RT Drug versus Initial 4-Drug HAART Strategies in AIDS Clinical Trials Group
RT Protocol 384.";
RL J. Acquir. Immune Defic. Syndr. 0:0-0(2007).
CC -!- SIMILARITY: Belongs to the retroviral Pol polyprotein family.
CC {ECO:0000256|RuleBase:RU004064}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EF549247; ABQ16411.1; -; Genomic_DNA.
DR MEROPS; A02.001; -.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR CDD; cd05482; HIV_retropepsin_like; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001995; Peptidase_A2_cat.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR034170; Retropepsin-like_cat_dom.
DR InterPro; IPR018061; Retropepsins.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; INTEGRASE-RELATED; 1.
DR Pfam; PF00077; RVP; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50175; ASP_PROT_RETROV; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750,
KW ECO:0000256|RuleBase:RU004064};
KW DNA integration {ECO:0000256|ARBA:ARBA00023195};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU004064};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|RuleBase:RU004064};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023195};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 17..86
FT /note="Peptidase A2"
FT /evidence="ECO:0000259|PROSITE:PS50175"
FT DOMAIN 140..330
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABQ16411.1"
FT NON_TER 343
FT /evidence="ECO:0000313|EMBL:ABQ16411.1"
SQ SEQUENCE 343 AA; 39029 MW; 069F17788FF16628 CRC64;
TLWQRPLVTV KIGGQLKEAL LDTGADDTVL EEMNLPGRWK PKMIGGIGGF IKVRQYDQVP
IEICGHKAIG TVLVGPTPVN IIGRNLLTQI GCTLNFXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXCTEMEKE GKISKIGPEN PYNTPVFAIK KKDSTKWRKL VDFRELNKXT
QDFWEVQLGI PHPAGLXKXK SXTVLDVGDA YFSVPLDXXF RKYTAFTIPS INNETPGIRY
QYNVLPQGWK GSPAIFQSSM TKILEPFRKQ NPEIVIYQYM DDLYVGSDLE IGQHRTKIEE
LRQHLLXWGF TTPDKKHQKE PPFLWMGYEL HPDKWTVQPI XLP
//