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Database: UniProt
Entry: A5I642_CLOBH
LinkDB: A5I642_CLOBH
Original site: A5I642_CLOBH 
ID   A5I642_CLOBH            Unreviewed;       343 AA.
AC   A5I642; A7G7C5;
DT   26-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2007, sequence version 1.
DT   24-JAN-2024, entry version 117.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081,
GN   ECO:0000313|EMBL:CAL84524.1};
GN   OrderedLocusNames=CBO2961 {ECO:0000313|EMBL:CAL84524.1};
OS   Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=441771 {ECO:0000313|EMBL:CAL84524.1, ECO:0000313|Proteomes:UP000001986};
RN   [1] {ECO:0000313|EMBL:CAL84524.1, ECO:0000313|Proteomes:UP000001986}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hall / ATCC 3502 / NCTC 13319 / Type A [Sanger]
RC   {ECO:0000313|Proteomes:UP000001986};
RX   PubMed=17519437; DOI=10.1101/gr.6282807;
RA   Sebaihia M., Peck M.W., Minton N.P., Thomson N.R., Holden M.T.G.,
RA   Mitchell W.J., Carter A.T., Bentley S.D., Mason D.R., Crossman L.,
RA   Paul C.J., Ivens A., Wells-Bennik M.H.J., Davis I.J., Cerdeno-Tarraga A.M.,
RA   Churcher C., Quail M.A., Chillingworth T., Feltwell T., Fraser A.,
RA   Goodhead I., Hance Z., Jagels K., Larke N., Maddison M., Moule S.,
RA   Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M.,
RA   White B., Whithead S., Parkhill J.;
RT   "Genome sequence of a proteolytic (Group I) Clostridium botulinum strain
RT   Hall A and comparative analysis of the clostridial genomes.";
RL   Genome Res. 17:1082-1092(2007).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AM412317; CAL84524.1; -; Genomic_DNA.
DR   RefSeq; WP_003357960.1; NC_009698.1.
DR   RefSeq; YP_001255454.1; NC_009495.1.
DR   RefSeq; YP_001388690.1; NC_009698.1.
DR   AlphaFoldDB; A5I642; -.
DR   GeneID; 5186942; -.
DR   KEGG; cbh:CLC_2857; -.
DR   KEGG; cbo:CBO2961; -.
DR   PATRIC; fig|413999.7.peg.2940; -.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000001986; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR013196; HTH_11.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   NCBIfam; TIGR00331; hrcA; 1.
DR   PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR   PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF08279; HTH_11; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001986};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW   Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW   Rule:MF_00081};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW   Rule:MF_00081};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW   Rule:MF_00081}.
FT   DOMAIN          11..71
FT                   /note="Helix-turn-helix type 11"
FT                   /evidence="ECO:0000259|Pfam:PF08279"
FT   DOMAIN          104..321
FT                   /note="Heat-inducible transcription repressor HrcA C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01628"
SQ   SEQUENCE   343 AA;  38832 MW;  47C567B8036AD08F CRC64;
     MDERKIRILQ AIIKDYINSG EPVGSRTIAK KYDLGVSSAT IRNEMADLED MGYLEQIHSS
     SGRKPSDKGY RLYVDKLMTL TALTEREKML IKDQAIDSAL YEIDKTIRHS ISILSEITKL
     TCLVKTPSMI KSRLRSIQII KVDKYNLLLI VITDNAMIKN TLLRVTKEID EGSLIKINNL
     LNQKLKGLNL REVNLELLNE LKKEMTGYGD ILKNILSSIY EALTDIEDAE IYMEGTTNIF
     NYPEYNDVDR AKEFLSMLND REKVEELLYV DSDIAVKIGK ENFVEDAKQC SVISAVYSIG
     KTPIGTIGVI GPTRIPYEKI ISAVATIVKE INDTLTNDKN IHK
//
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