ID A5I642_CLOBH Unreviewed; 343 AA.
AC A5I642; A7G7C5;
DT 26-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2007, sequence version 1.
DT 24-JAN-2024, entry version 117.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081,
GN ECO:0000313|EMBL:CAL84524.1};
GN OrderedLocusNames=CBO2961 {ECO:0000313|EMBL:CAL84524.1};
OS Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=441771 {ECO:0000313|EMBL:CAL84524.1, ECO:0000313|Proteomes:UP000001986};
RN [1] {ECO:0000313|EMBL:CAL84524.1, ECO:0000313|Proteomes:UP000001986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hall / ATCC 3502 / NCTC 13319 / Type A [Sanger]
RC {ECO:0000313|Proteomes:UP000001986};
RX PubMed=17519437; DOI=10.1101/gr.6282807;
RA Sebaihia M., Peck M.W., Minton N.P., Thomson N.R., Holden M.T.G.,
RA Mitchell W.J., Carter A.T., Bentley S.D., Mason D.R., Crossman L.,
RA Paul C.J., Ivens A., Wells-Bennik M.H.J., Davis I.J., Cerdeno-Tarraga A.M.,
RA Churcher C., Quail M.A., Chillingworth T., Feltwell T., Fraser A.,
RA Goodhead I., Hance Z., Jagels K., Larke N., Maddison M., Moule S.,
RA Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M.,
RA White B., Whithead S., Parkhill J.;
RT "Genome sequence of a proteolytic (Group I) Clostridium botulinum strain
RT Hall A and comparative analysis of the clostridial genomes.";
RL Genome Res. 17:1082-1092(2007).
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC Rule:MF_00081}.
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DR EMBL; AM412317; CAL84524.1; -; Genomic_DNA.
DR RefSeq; WP_003357960.1; NC_009698.1.
DR RefSeq; YP_001255454.1; NC_009495.1.
DR RefSeq; YP_001388690.1; NC_009698.1.
DR AlphaFoldDB; A5I642; -.
DR GeneID; 5186942; -.
DR KEGG; cbh:CLC_2857; -.
DR KEGG; cbo:CBO2961; -.
DR PATRIC; fig|413999.7.peg.2940; -.
DR HOGENOM; CLU_050019_1_0_9; -.
DR OMA; DYPGTMG; -.
DR Proteomes; UP000001986; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR013196; HTH_11.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR NCBIfam; TIGR00331; hrcA; 1.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR Pfam; PF08279; HTH_11; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001986};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00081}.
FT DOMAIN 11..71
FT /note="Helix-turn-helix type 11"
FT /evidence="ECO:0000259|Pfam:PF08279"
FT DOMAIN 104..321
FT /note="Heat-inducible transcription repressor HrcA C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01628"
SQ SEQUENCE 343 AA; 38832 MW; 47C567B8036AD08F CRC64;
MDERKIRILQ AIIKDYINSG EPVGSRTIAK KYDLGVSSAT IRNEMADLED MGYLEQIHSS
SGRKPSDKGY RLYVDKLMTL TALTEREKML IKDQAIDSAL YEIDKTIRHS ISILSEITKL
TCLVKTPSMI KSRLRSIQII KVDKYNLLLI VITDNAMIKN TLLRVTKEID EGSLIKINNL
LNQKLKGLNL REVNLELLNE LKKEMTGYGD ILKNILSSIY EALTDIEDAE IYMEGTTNIF
NYPEYNDVDR AKEFLSMLND REKVEELLYV DSDIAVKIGK ENFVEDAKQC SVISAVYSIG
KTPIGTIGVI GPTRIPYEKI ISAVATIVKE INDTLTNDKN IHK
//