ID A5ILE4_THEP1 Unreviewed; 593 AA.
AC A5ILE4;
DT 26-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Sulfatase {ECO:0000313|EMBL:ABQ47017.1};
GN OrderedLocusNames=Tpet_0999 {ECO:0000313|EMBL:ABQ47017.1};
OS Thermotoga petrophila (strain ATCC BAA-488 / DSM 13995 / JCM 10881 /
OS RKU-1).
OC Bacteria; Thermotogota; Thermotogae; Thermotogales; Thermotogaceae;
OC Thermotoga.
OX NCBI_TaxID=390874 {ECO:0000313|EMBL:ABQ47017.1, ECO:0000313|Proteomes:UP000006558};
RN [1] {ECO:0000313|Proteomes:UP000006558}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-488 / DSM 13995 / JCM 10881 / RKU-1
RC {ECO:0000313|Proteomes:UP000006558};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C.,
RA Tapia R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.;
RT "Complete sequence of Thermotoga petrophila RKU-1.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABQ47017.1, ECO:0000313|Proteomes:UP000006558}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-488 / DSM 13995 / JCM 10881 / RKU-1
RC {ECO:0000313|Proteomes:UP000006558};
RX PubMed=19307556; DOI=10.1073/pnas.0901260106;
RA Zhaxybayeva O., Swithers K.S., Lapierre P., Fournier G.P., Bickhart D.M.,
RA DeBoy R.T., Nelson K.E., Nesbo C.L., Doolittle W.F., Gogarten J.P.,
RA Noll K.M.;
RT "On the chimeric nature, thermophilic origin, and phylogenetic placement of
RT the Thermotogales.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:5865-5870(2009).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP000702; ABQ47017.1; -; Genomic_DNA.
DR RefSeq; WP_011943554.1; NC_009486.1.
DR AlphaFoldDB; A5ILE4; -.
DR STRING; 390874.Tpet_0999; -.
DR KEGG; tpt:Tpet_0999; -.
DR eggNOG; COG1368; Bacteria.
DR HOGENOM; CLU_021310_1_1_0; -.
DR Proteomes; UP000006558; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16015; LTA_synthase; 1.
DR Gene3D; 3.30.1120.170; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR012160; LtaS-like.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR47371; LIPOTEICHOIC ACID SYNTHASE; 1.
DR PANTHER; PTHR47371:SF3; PHOSPHOGLYCEROL TRANSFERASE I; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR PIRSF; PIRSF005091; Mmb_sulf_HI1246; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Manganese {ECO:0000256|PIRSR:PIRSR005091-2};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR005091-2};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 202..492
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
FT ACT_SITE 254
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-1"
FT BINDING 210
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT BINDING 254
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT BINDING 367
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-2"
FT BINDING 427
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT BINDING 428
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
SQ SEQUENCE 593 AA; 67553 MW; C5814442A211825D CRC64;
MSDYLLIVFL AAKIVLFYVP TLSSFSVSVV FSTAGWLMLL LLVFKGGHKL LYTVLSLLLF
VDFLYFQNFG NLPSIKEVVL LPQVGDLGGE IKYFIDLYSL LFVADLPFVW FFFKENTKRT
FSLSSLFVLV LSFTFLGAVH TSQNLQSKFV FNRYGVFDYH VQDIINLFVN KKEENNDLAV
SSVRSETAEP SQKILFGIGK GKNVIVVQME SLQNFVIGLE VNGQEITPNI NSFLRDSGTV
YFSNCYQQVG SGNTADAEFV VNTSLHTLGD SVVYEEYPVI NLPALPRIMK QNGYHTIAFH
GNVGWFWNRE EVYKHIGFDE FVSLEDFQQD EVFGMGLADV SFFKQAVQKL RNYPQPFYAF
LITISSHTPF VIPEEHRKLE LPEDISDTIV GHYLQAIHYA DEAFGVFLDE LKRAGLYENS
VIVLYGDHAG LYPFNREVKT KIPEILDREF SFEIALNIPF AIHIPGENIR RVVNIPGGQI
DFLPTILNVM GINYREGFFM GQDLLNAKHG FAALRYHVPD GSFIDDNRVF IVSWDGRLDK
SLAVDRKNGT PQRYVEFLDG YVKAIQQIEA SRYFILRNCQ PLQKVAKDQT SSR
//
