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Database: UniProt
Entry: A5IP58
LinkDB: A5IP58
Original site: A5IP58 
ID   PTG3C_STAA9             Reviewed;         681 AA.
AC   A5IP58;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 1.
DT   16-APR-2014, entry version 58.
DE   RecName: Full=PTS system glucose-specific EIICBA component;
DE   AltName: Full=EIICBA-Glc;
DE            Short=EII-Glc;
DE   Includes:
DE     RecName: Full=Glucose permease IIC component;
DE     AltName: Full=PTS system glucose-specific EIIC component;
DE   Includes:
DE     RecName: Full=Glucose-specific phosphotransferase enzyme IIB component;
DE              EC=2.7.1.69;
DE     AltName: Full=PTS system glucose-specific EIIB component;
DE   Includes:
DE     RecName: Full=Glucose-specific phosphotransferase enzyme IIA component;
DE              EC=2.7.1.-;
DE     AltName: Full=PTS system glucose-specific EIIA component;
GN   Name=ptsG; Synonyms=glcA; OrderedLocusNames=SaurJH9_0174;
OS   Staphylococcus aureus (strain JH9).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcus.
OX   NCBI_TaxID=359786;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JH9;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P.,
RA   Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Tomasz A., Richardson P.;
RT   "Complete sequence of chromosome of Staphylococcus aureus subsp.
RT   aureus JH9.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The phosphoenolpyruvate-dependent sugar
CC       phosphotransferase system (sugar PTS), a major carbohydrate active
CC       -transport system, catalyzes the phosphorylation of incoming sugar
CC       substrates concomitantly with their translocation across the cell
CC       membrane. This system is involved in glucose transport (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Protein EIIB N(pi)-phospho-L-
CC       histidine/cysteine + sugar = protein EIIB + sugar phosphate.
CC   -!- CATALYTIC ACTIVITY: Protein EIIA N(pi)-phospho-L-histidine +
CC       protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-
CC       histidine/cysteine.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (By similarity).
CC   -!- DOMAIN: The EIIC domain forms the PTS system translocation channel
CC       and contains the specific substrate-binding site.
CC   -!- DOMAIN: The EIIB domain is phosphorylated by phospho-EIIA on a
CC       cysteinyl or histidyl residue, depending on the transported sugar.
CC       Then, it transfers the phosphoryl group to the sugar substrate
CC       concomitantly with the sugar uptake processed by the EIIC domain.
CC   -!- DOMAIN: The EIIA domain is phosphorylated by phospho-HPr on a
CC       histidyl residue. Then, it transfers the phosphoryl group to the
CC       EIIB domain.
CC   -!- SIMILARITY: Contains 1 PTS EIIA type-1 domain.
CC   -!- SIMILARITY: Contains 1 PTS EIIB type-1 domain.
CC   -!- SIMILARITY: Contains 1 PTS EIIC type-1 domain.
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DR   EMBL; CP000703; ABQ47981.1; -; Genomic_DNA.
DR   RefSeq; YP_001245557.1; NC_009487.1.
DR   ProteinModelPortal; A5IP58; -.
DR   SMR; A5IP58; 430-498, 529-681.
DR   STRING; 359786.SaurJH9_0174; -.
DR   PRIDE; A5IP58; -.
DR   EnsemblBacteria; ABQ47981; ABQ47981; SaurJH9_0174.
DR   GeneID; 5167479; -.
DR   KEGG; saj:SaurJH9_0174; -.
DR   PATRIC; 19538012; VBIStaAur42398_0217.
DR   eggNOG; COG1263; -.
DR   HOGENOM; HOG000250993; -.
DR   KO; K02763; -.
DR   KO; K02764; -.
DR   KO; K02765; -.
DR   OMA; CIRRFNL; -.
DR   OrthoDB; EOG6FFS9V; -.
DR   ProtClustDB; CLSK872840; -.
DR   BioCyc; SAUR359786:GJEM-173-MONOMER; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005355; F:glucose transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005351; F:sugar:hydrogen symporter activity; IEA:InterPro.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1360.60; -; 1.
DR   InterPro; IPR011055; Dup_hybrid_motif.
DR   InterPro; IPR018113; PTrfase_EIIB/Cys_phosph_CS.
DR   InterPro; IPR001127; PTS_EIIA_1_perm.
DR   InterPro; IPR001996; PTS_EIIB_1.
DR   InterPro; IPR003352; PTS_EIIC.
DR   InterPro; IPR013013; PTS_EIIC_1.
DR   InterPro; IPR011535; PTS_Glc-like_IIB_component.
DR   InterPro; IPR011299; PTS_IIBC_glc.
DR   Pfam; PF00358; PTS_EIIA_1; 1.
DR   Pfam; PF00367; PTS_EIIB; 1.
DR   Pfam; PF02378; PTS_EIIC; 1.
DR   SUPFAM; SSF51261; SSF51261; 1.
DR   SUPFAM; SSF55604; SSF55604; 1.
DR   TIGRFAMs; TIGR00826; EIIB_glc; 1.
DR   TIGRFAMs; TIGR00830; PTBA; 1.
DR   TIGRFAMs; TIGR02002; PTS-II-BC-glcB; 1.
DR   PROSITE; PS51093; PTS_EIIA_TYPE_1; 1.
DR   PROSITE; PS00371; PTS_EIIA_TYPE_1_HIS; 1.
DR   PROSITE; PS51098; PTS_EIIB_TYPE_1; 1.
DR   PROSITE; PS01035; PTS_EIIB_TYPE_1_CYS; 1.
DR   PROSITE; PS51103; PTS_EIIC_TYPE_1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Complete proteome; Kinase; Membrane;
KW   Phosphotransferase system; Sugar transport; Transferase;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1    681       PTS system glucose-specific EIICBA
FT                                component.
FT                                /FTId=PRO_5000247134.
FT   TRANSMEM     16     36       Helical; (Potential).
FT   TRANSMEM     73     93       Helical; (Potential).
FT   TRANSMEM    126    146       Helical; (Potential).
FT   TRANSMEM    170    190       Helical; (Potential).
FT   TRANSMEM    199    219       Helical; (Potential).
FT   TRANSMEM    273    293       Helical; (Potential).
FT   TRANSMEM    303    323       Helical; (Potential).
FT   TRANSMEM    328    348       Helical; (Potential).
FT   TRANSMEM    355    375       Helical; (Potential).
FT   TRANSMEM    383    403       Helical; (Potential).
FT   DOMAIN        3    414       PTS EIIC type-1.
FT   DOMAIN      425    506       PTS EIIB type-1.
FT   DOMAIN      551    655       PTS EIIA type-1.
FT   ACT_SITE    447    447       Phosphocysteine intermediate; for EIIB
FT                                activity (By similarity).
FT   ACT_SITE    603    603       Tele-phosphohistidine intermediate; for
FT                                EIIA activity (By similarity).
SQ   SEQUENCE   681 AA;  73958 MW;  040ADA543CF31520 CRC64;
     MRKKLFGQLQ RIGKALMLPV AILPAAGLLL AIGTAIQGEA LQHYLPFIQN GGVQNVAKLM
     TAAGSIIFEN LPMIFALGVA IGLAGGDGVA AIAAFVGYII MNKTMGDFLQ VTPKNVTDPA
     SGYASILGIP TLQTGVFGGI IIGALAAWCY NKFYNINLPS YLGFFAGKRF VPIMMATTSF
     ILAFPMALIW PTIQSGLNAF STGLLDSNTG VAVFLFGFIK RLLIPFGLHH IFHAPFWFEF
     GSWKNAAGEI IHGDQRIFIE QIREGAHLTA GKFMQGEFPV MMFGLPAAAL AIYHTAKPEN
     KKVVAGLMGS AALTSFLTGI TEPLEFSFLF VAPLLFFIHA VLDGLSFLTL YLLDVHLGYT
     FSGGFIDYVL LGVLPNKTQW WLVIPVGLVY AVIYYFVFRF LIVKLKYKTP GREDKQSQAV
     TASATELPYA VLEAMGGKAN IKHLDACITR LRVEVNDKSK VDVPGLKDLG ASGVLEVGNN
     MQAIFGPKSD QIKHEMQQIM NGQVVENPTT MEDDKDETVV VAEDKSATSE LSHIVHAPLT
     GEVTPLSEVP DQVFSEKMMG DGIAIKPSQG EVRAPFNGKI QMIFPTKHAI GLVSDSGLEL
     LIHIGLDTVK LNGEGFTLHV EEGQEVKQGD LLINFDLDYI RNHAKSDITP IIVTQGNITN
     LDFKQGEHGN ISFGDQLFEA K
//
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