ID A5JIB5_HBV Unreviewed; 394 AA.
AC A5JIB5;
DT 26-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2007, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=P {ECO:0000313|EMBL:ABQ44032.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:ABQ44032.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:ABQ44032.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HBVDG24 {ECO:0000313|EMBL:ABQ44032.1};
RX PubMed=17451771; DOI=10.1016/j.virol.2007.03.015;
RA De Maddalena C., Giambelli C., Tanzi E., Colzani D., Schiavini M.,
RA Milazzo L., Bernini F., Ebranati E., Cargnel A., Bruno R., Galli M.,
RA Zehender G.;
RT "High level of genetic heterogeneity in S and P genes of genotype D
RT hepatitis B virus.";
RL Virology 365:113-124(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; EF514306; ABQ44032.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 117..360
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABQ44032.1"
FT NON_TER 394
FT /evidence="ECO:0000313|EMBL:ABQ44032.1"
SQ SEQUENCE 394 AA; 44215 MW; B33BEAB57BB7D3AC CRC64;
WSIRAGFHPT ARRPFGVEPS GSGHTTNFAS ESASCLHQSP VRKAAYPAVS TSEKYSSSGY
AVEFHNLPPN SARSQSERPV FPCWWLQFRN SKPCSDYCLS HIVNLLEDWG PCAEHGEHHI
RTPRTPSRVT GGVFLVDKNP HNTAESRLVV DFSQFSRGNY RVSWPKFAVP NLQSLTNLLS
SNLSWLSLDV SAAFYHIPLH PAAMPHLLVG SSGLSRYVAR LSNNPRILNH QHGTMPNLHD
SCSRNLYVSL LLLYQTFGRK LHLYSHPIIL GFRKIPMGVG LSPFLLAQFT SSLCSVVRRA
FPHCLAFSYM DDMVLGAKSV SHLESLFTAV TNFLLSLGIH LNPNKTKRWG YSLNFMGYVI
GGYGSLPQEH IVQKIKECFR KLPINRPIDW KVCQ
//
