ID A5JIJ1_HBV Unreviewed; 394 AA.
AC A5JIJ1;
DT 26-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2007, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=P {ECO:0000313|EMBL:ABQ44108.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:ABQ44108.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:ABQ44108.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HBVDP43 {ECO:0000313|EMBL:ABQ44108.1};
RX PubMed=17451771; DOI=10.1016/j.virol.2007.03.015;
RA De Maddalena C., Giambelli C., Tanzi E., Colzani D., Schiavini M.,
RA Milazzo L., Bernini F., Ebranati E., Cargnel A., Bruno R., Galli M.,
RA Zehender G.;
RT "High level of genetic heterogeneity in S and P genes of genotype D
RT hepatitis B virus.";
RL Virology 365:113-124(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; EF514325; ABQ44108.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 117..360
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABQ44108.1"
FT NON_TER 394
FT /evidence="ECO:0000313|EMBL:ABQ44108.1"
SQ SEQUENCE 394 AA; 44273 MW; 930ABF885B9801E7 CRC64;
WSIRAGIHPT ARRPFGVEPS GSGHNTNLAS KSASCLYQSP VRKAAYPAVS TFEKHSSSGH
AVELHNLPPN SARSQGERPV FPCWWLQFRN SKPCSDYCLS HIVNLLEDWG PCAEHGEHHI
RIPRTPARVT GGVFLVDKNP HNTAESRLVV DFSQFSRGNY RVSWPKFAVP NLQSLTNLLS
SNLSWLSLDV SAAFYHLPLH PAAMPHLLVG SSGLSRYVAR LSSNSRIFNH QRGTMQNLHD
YCSRNLYVSL LLLYQTFGRK LHLYSHPIIL GFRKIPMGVG LSPFLLAQFT SAICSVVRRA
FPHCLAFSYM DDVVLGAKSV QHLESLFTAV TNFLLSLGIH LNPNKTKRWG YSLNFMGYVI
GCYGSLPQDH IIQKIKECFR KLPVNRPIDW KVCQ
//
