ID A5JIK7_HBV Unreviewed; 394 AA.
AC A5JIK7;
DT 26-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2007, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=P {ECO:0000313|EMBL:ABQ44124.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:ABQ44124.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:ABQ44124.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HBVDS47 {ECO:0000313|EMBL:ABQ44124.1};
RX PubMed=17451771; DOI=10.1016/j.virol.2007.03.015;
RA De Maddalena C., Giambelli C., Tanzi E., Colzani D., Schiavini M.,
RA Milazzo L., Bernini F., Ebranati E., Cargnel A., Bruno R., Galli M.,
RA Zehender G.;
RT "High level of genetic heterogeneity in S and P genes of genotype D
RT hepatitis B virus.";
RL Virology 365:113-124(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; EF514329; ABQ44124.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 117..360
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABQ44124.1"
FT NON_TER 394
FT /evidence="ECO:0000313|EMBL:ABQ44124.1"
SQ SEQUENCE 394 AA; 44328 MW; EF9FE97B4AD17886 CRC64;
WSIRAGFHPT ARRPFGVEPS GSGHTTNFAS KSASCLHQSP DRKAAYPAVS TFEKHSSSGH
AVEFHNLSPN SARSQSERPV FPCWWLQFRS SKPCSDYCLS LIVNLLEDWG PCVEHGEHHI
RIPRTPSRVT GGVFLVDKNP HNTAESRLVV DFSQFSRGNY RVSWPKFAVP NLQSLTNLLS
SNLSWLSLDV SAAFYHLPLH PAAMPHLLVG SSGLSRYVAR LSSTSRILNH QHGTMPNLHD
YCSRNLYVSL LLLYQTYGRK LHLYSHPIIL GFRKIPMGVG LSPFLLAQFT SAICSVVRRA
FPHCLAFSYM DDVVLGAKSV QHLESLFTAV TNFLLSLGIH LNPHKTKRWG YSLNFMGYVI
GSYGSLPQEH IIHKIKECFR KLPINRPIDW KVCQ
//
