ID A5JIN4_HBV Unreviewed; 394 AA.
AC A5JIN4;
DT 26-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2007, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=P {ECO:0000313|EMBL:ABQ44151.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:ABQ44151.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:ABQ44151.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HBVDD54 {ECO:0000313|EMBL:ABQ44151.1};
RX PubMed=17451771; DOI=10.1016/j.virol.2007.03.015;
RA De Maddalena C., Giambelli C., Tanzi E., Colzani D., Schiavini M.,
RA Milazzo L., Bernini F., Ebranati E., Cargnel A., Bruno R., Galli M.,
RA Zehender G.;
RT "High level of genetic heterogeneity in S and P genes of genotype D
RT hepatitis B virus.";
RL Virology 365:113-124(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; EF514336; ABQ44151.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 117..360
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABQ44151.1"
FT NON_TER 394
FT /evidence="ECO:0000313|EMBL:ABQ44151.1"
SQ SEQUENCE 394 AA; 44207 MW; A69C56A0543EA5C5 CRC64;
WSIRAGFHPT ARRPFGVEPS GSGHTTNFAS KSASCLHQSP VRKAAYPAVS TFEKHSSSGH
AVELHNLPPN SARSQSERPV FPCWWLQFRN SKPCSDYCLS LIVNLLEDWG PCVEHGEHHI
RIPRTPSRVT GGVFLVDKNP HNTAESRLVV DFSQFSRGKY RVSWPKFAVP NLQSLTNLLS
SNLSWLSLDV SAAFYHIPLH PAAMPHLLVG SSGLSRYIAR LSSDSRILNH QHGTMPNLHD
SCSRNLYVSL LLLYQTFGRK LHLYSHPIIL GFRKIPMGVG LSPFLMAQFT SAICSVVRRA
FPHCLAFSYV DDVVLGAKSV QHLESLFTAV TNFLLSLGIH LNPNKTKRWG YSLNFMGYVI
GCYGSLPQEH IVQKIKECFR KLPVNRPIDW KVCQ
//
