ID A5JZ73_PLAVS Unreviewed; 2192 AA.
AC A5JZ73;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 24-JAN-2024, entry version 92.
DE SubName: Full=Carbamoyl phosphate synthetase II, putative {ECO:0000313|EMBL:EDL47284.1};
GN ORFNames=PVX_122240 {ECO:0000313|EMBL:EDL47284.1};
OS Plasmodium vivax (strain Salvador I).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=126793 {ECO:0000313|EMBL:EDL47284.1, ECO:0000313|Proteomes:UP000008333};
RN [1] {ECO:0000313|EMBL:EDL47284.1, ECO:0000313|Proteomes:UP000008333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Salvador I {ECO:0000313|EMBL:EDL47284.1,
RC ECO:0000313|Proteomes:UP000008333};
RX PubMed=18843361; DOI=10.1038/nature07327;
RA Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E.,
RA Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q., Coulson R.M.,
RA Crabb B.S., Del Portillo H.A., Essien K., Feldblyum T.V.,
RA Fernandez-Becerra C., Gilson P.R., Gueye A.H., Guo X., Kang'a S.,
RA Kooij T.W., Korsinczky M., Meyer E.V., Nene V., Paulsen I., White O.,
RA Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J.,
RA Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J.,
RA Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.;
RT "Comparative genomics of the neglected human malaria parasite Plasmodium
RT vivax.";
RL Nature 455:757-763(2008).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDL47284.1}.
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DR EMBL; AAKM01000001; EDL47284.1; -; Genomic_DNA.
DR RefSeq; XP_001617011.1; XM_001616961.1.
DR STRING; 126793.A5JZ73; -.
DR EnsemblProtists; EDL47284; EDL47284; PVX_122240.
DR GeneID; 5476320; -.
DR KEGG; pvx:PVX_122240; -.
DR VEuPathDB; PlasmoDB:PVX_122240; -.
DR InParanoid; A5JZ73; -.
DR OMA; MGISKDY; -.
DR PhylomeDB; A5JZ73; -.
DR Proteomes; UP000008333; Chromosome 14.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd01744; GATase1_CPSase; 1.
DR CDD; cd01423; MGS_CPS_I_III; 1.
DR Gene3D; 3.40.50.20; -; 2.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 2.
DR Gene3D; 3.50.30.20; Carbamoyl-phosphate synthase small subunit, N-terminal domain; 1.
DR Gene3D; 1.10.1030.10; Carbamoyl-phosphate synthetase, large subunit oligomerisation domain; 1.
DR Gene3D; 3.40.50.1380; Methylglyoxal synthase-like domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR005480; CarbamoylP_synth_lsu_oligo.
DR InterPro; IPR036897; CarbamoylP_synth_lsu_oligo_sf.
DR InterPro; IPR002474; CarbamoylP_synth_ssu_N.
DR InterPro; IPR036480; CarbP_synth_ssu_N_sf.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR005483; CbamoylP_synth_lsu_CPSase_dom.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR035686; CPSase_GATase1.
DR InterPro; IPR017926; GATASE.
DR InterPro; IPR011607; MGS-like_dom.
DR InterPro; IPR036914; MGS-like_dom_sf.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR PANTHER; PTHR11405:SF4; CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN; 1.
DR PANTHER; PTHR11405; CARBAMOYLTRANSFERASE FAMILY MEMBER; 1.
DR Pfam; PF02786; CPSase_L_D2; 2.
DR Pfam; PF02787; CPSase_L_D3; 1.
DR Pfam; PF00988; CPSase_sm_chain; 1.
DR Pfam; PF00117; GATase; 1.
DR Pfam; PF02142; MGS; 1.
DR PRINTS; PR00098; CPSASE.
DR PRINTS; PR00099; CPSGATASE.
DR PRINTS; PR00096; GATASE.
DR SMART; SM01096; CPSase_L_D3; 1.
DR SMART; SM01097; CPSase_sm_chain; 1.
DR SMART; SM00851; MGS; 1.
DR SUPFAM; SSF48108; Carbamoyl phosphate synthetase, large subunit connection domain; 1.
DR SUPFAM; SSF52021; Carbamoyl phosphate synthetase, small subunit N-terminal domain; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 2.
DR SUPFAM; SSF52335; Methylglyoxal synthase-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 2.
DR PROSITE; PS50975; ATP_GRASP; 2.
DR PROSITE; PS00866; CPSASE_1; 1.
DR PROSITE; PS00867; CPSASE_2; 2.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
DR PROSITE; PS51855; MGS; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409};
KW Glutamine amidotransferase {ECO:0000256|PROSITE-ProRule:PRU00605};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000008333}.
FT DOMAIN 766..959
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 1776..1967
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 2033..2192
FT /note="MGS-like"
FT /evidence="ECO:0000259|PROSITE:PS51855"
FT REGION 251..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1338..1379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1492..1551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1340..1371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1521..1544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 514
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 600
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 602
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
SQ SEQUENCE 2192 AA; 247387 MW; 553C9C9228E33556 CRC64;
MMSTEFWPDY DYKTVGKLIL EDDTEFVGYS VGYEGCKEEE KAAPKREAIK GSNSHQVLEK
KEYLKEDVLF KNSKIENEDY IVTGEVIFNT AMVGYPEALT DPSYFGQILV LTFPSIGNYG
VEKVHHDNFG LVKNFESNKI QIQGLVICEY TKKSYHYNSC ITLSEWLKLY KVPCIGGIDT
RALTKILREK GSMLGKIVIY KNAKNVNKLY KEISLFDPGQ IDTIKYVCNH YIRVIKLGRV
NYYNNCKGKE DSKGANDVND YSPEEEENGS SSLTNGNGYN YQSVSSFEKM DFNKNSNQHS
LLRGRMNLLT SSEENVDHCS GYQEYSTNGG KKDAFFNLRG ACEYDKYLID LEENSSFHDG
NVDQYGHYDV ELSLQRGGLS EGGNETCTAS ISDEGSAPQM EATFNLNNDY STYVKKKMNK
GEFLSLVNKR KSDAEKIIVI VDCGIKNSII KNLMKNGKDL PLTYIIVPYY YDYNSIDYDA
VLLSNGPGDP KKCDFLIETL KKSLQKNNLI FGICLGNQLL GISLGCETYK MKYGNRGVNQ
PVIQLVDNKC YITSQNHGYC LKKKSILKRK ELAISYVNAN DKSVEGITHK NGRFYSVQFH
PEGNNGPEDT SFLFKNFLID MFNKKREFRE HIGHNIIYIK KKVLLLGSGG LCIGQAGEFD
YSGTQAIKSL KECGIYVILV NPNIATVQTS KGLADKVYFL PVNCEFVEKI IKKEKPDFIL
CTFGGQTALN CALMLEQKKV LKKNNCLALG TSLESILITE NRSMFAEKLR EINEIIAPYG
SARNVEQAIE VANKIGYPIL VRTTFSLGGL NSSFINNEEE LIKKCKEIFL QTDNEIFIDK
SLKGWKEIEY ELLRDNKNNC IAICNMENID PLGIHTGDSI VVAPSQTLSN YEYYKFREIA
LKVITHLNII GECNIQFGIN PKTGEYCIIE VNARLSRSSA LASKATGYPL AYISAKIALG
YDLISLKNSI TKKTTACFEP SLDYITTKIP RWDLNKFEFA SKTMNSSMKS VGEVMSIGRT
FEESIQKSLR CIDDNYLGFS NTYCIDWDEA KIVDELKNPS PKRIDAIHQA FHLNIPMEKI
HELTHIEYWF LHKFYNIFNL QNRLKTLSLE QLSFYDLKYF KKHGFSDKQI AHYLSFNNPK
VTEATVMRYR ESLGLHPHIK VIDTLSAEFP ALTNYLYLTY QGVEHDVLPL NMKRKKKLPA
EGTGKKANRA GKLVHPHMAT EMQEKEAVKQ LQMGCDQNGY SETLGNDVDV TVMSTKVEGA
VGKQVQMVGS SPLGGSKEGP LFSAEGAQMN VHASPSNQML SKDGKEEKSI GSDETNVFSV
KNCTNNVTFP NGSHIAGGAM KNNGMQSTTE AGQNSKEAKE SSANNTSKEG CSKKVPNREV
LMNHRMDDIS NRSSHSTNDQ LYLENFNTSD EEMTNKNGDA HYLSKKKRNF SDSKGAGNLY
YLVDSVYNNE YKMSKMKELI NSENTDSNDS VQCEQRGFVV KSGQVGRRFG ATPAAEDSLP
MHVPHYAGRK TNVGNAESGK GDSLPHHEIE RERSKGRSSS KKRETKLNSS GINFDDGNSD
CFSELSYLRN CTKSSDAEND DIDDDDAYYN GGDDVYTCST DNGMFDDYAE SHNTFSSKES
EGSSVYSENE NIFNEKFNDI GFKIIHDRNE KEKEKKKCFI VLGCGCYRIG SSVEFDWSAI
HCVKTIRKLN HKAILINCNP ETVSTDYDES DRLYFDEITT EVIKFIYSFE KSHGVIIAFG
GQTSNNLVFS LYKNSVNILG TSAKSVDCCE NRNKFSNLCD SLKIDQPKWN KFTKLSKAIQ
FANEVKFPVL VRPSYVLSGA AMRVVNCFEE LKNFLMKAAI VSKDNPVVIS KFIENAKEIE
IDCVSKNGKI INYAISEHVE NAGVHSGDAT LILPAQNIYV ETHRKIKKIS EKISKSLNIS
GPFNIQFICH QNEIKIIECN LRASRTFPFI SKALNLNFID LATRILMGYD VKPINISLID
LEYTAVKSPI FSFNRLHGSD CILGVEMKST GEVACFGLNK YEALLKSLIA TGMKLPKKSI
LISIKNLNNK LAFEEPFQLL FLMGFTIYAT EGTYDFYSKF LESFNVTKAS KFHQRLIRVH
NKSSENLMPN ITDLIMNHKV EMVINITDTL KTKVSSNGYK IRRLASDFQV PLITNMKLSS
LFIDSLYRKF SRRKEKKPFY TIKSYDEYIS LV
//