ID A5K0V5_PLAVS Unreviewed; 690 AA.
AC A5K0V5;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 24-JAN-2024, entry version 80.
DE RecName: Full=Diphthamide biosynthesis protein 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=PVX_085065 {ECO:0000313|EMBL:EDL46952.1};
OS Plasmodium vivax (strain Salvador I).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=126793 {ECO:0000313|EMBL:EDL46952.1, ECO:0000313|Proteomes:UP000008333};
RN [1] {ECO:0000313|EMBL:EDL46952.1, ECO:0000313|Proteomes:UP000008333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Salvador I {ECO:0000313|EMBL:EDL46952.1,
RC ECO:0000313|Proteomes:UP000008333};
RX PubMed=18843361; DOI=10.1038/nature07327;
RA Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E.,
RA Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q., Coulson R.M.,
RA Crabb B.S., Del Portillo H.A., Essien K., Feldblyum T.V.,
RA Fernandez-Becerra C., Gilson P.R., Gueye A.H., Guo X., Kang'a S.,
RA Kooij T.W., Korsinczky M., Meyer E.V., Nene V., Paulsen I., White O.,
RA Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J.,
RA Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J.,
RA Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.;
RT "Comparative genomics of the neglected human malaria parasite Plasmodium
RT vivax.";
RL Nature 455:757-763(2008).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- PATHWAY: Protein modification; peptidyl-diphthamide biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005156}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDL46952.1}.
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DR EMBL; AAKM01000002; EDL46952.1; -; Genomic_DNA.
DR RefSeq; XP_001616679.1; XM_001616629.1.
DR AlphaFoldDB; A5K0V5; -.
DR STRING; 126793.A5K0V5; -.
DR EnsemblProtists; EDL46952; EDL46952; PVX_085065.
DR GeneID; 5475987; -.
DR KEGG; pvx:PVX_085065; -.
DR VEuPathDB; PlasmoDB:PVX_085065; -.
DR InParanoid; A5K0V5; -.
DR OMA; IEMYILL; -.
DR PhylomeDB; A5K0V5; -.
DR UniPathway; UPA00559; -.
DR Proteomes; UP000008333; Chromosome 13.
DR GO; GO:0090560; F:2-(3-amino-3-carboxypropyl)histidine synthase activity; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017183; P:protein histidyl modification to diphthamide; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.11840; Diphthamide synthesis DPH1/DPH2 domain 1; 1.
DR Gene3D; 3.40.50.11860; Diphthamide synthesis DPH1/DPH2 domain 3; 1.
DR InterPro; IPR016435; DPH1/DPH2.
DR InterPro; IPR042263; DPH1/DPH2_1.
DR InterPro; IPR042265; DPH1/DPH2_3.
DR NCBIfam; TIGR00322; diphth2_R; 2.
DR PANTHER; PTHR10762:SF2; 2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2; 1.
DR PANTHER; PTHR10762; DIPHTHAMIDE BIOSYNTHESIS PROTEIN; 1.
DR Pfam; PF01866; Diphthamide_syn; 2.
DR SFLD; SFLDS00032; Radical_SAM_3-amino-3-carboxyp; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008333}.
FT REGION 86..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 690 AA; 75717 MW; A5E6A3BE71F54BA2 CRC64;
MGRPHSSDIF AKYQVELAAG IISKNNYRRV AVQLPDCMLE DSLLLSNAIQ GELHKGGGAP
LPYSNEPTGM IPPCCGEKSP KGDAPICGKE ANSVGSTPSD PPQRSTPDGV DVYILGDTSV
NECCEDYVSA EHVQADLLLH YGPSCQSFIT PSIPSVYLFS EVKPEEAFYQ SVRERFIRSN
FPGGGDVCIV LCDVAYTGCM PRLVDAFLEV SGVEAVGGGA ARGAGENRAK PLFLVDGRLV
GGKSFLRRGG EAATGDAANT AAINSNIVVG LHRVATNVQG KHCYGDHGNY VELDAHEDLA
GKYAFFCGRL LTRVLYSPRL GTLLYEVIRT EEMSPPWGTI LTNGQAQRTH LFLFANGNVN
LRRRCVLEYE CCPDRVHICE SEQQEGEAEK HLGANGNIEI CHFEKKDDLD KLLLKRYSLI
EKCKLVDTFG ILMANVNLQK SREMKRCLSY ILRSRGKKCF TIATNKLNGP KMENFCDVEM
YILLSCPEKS FLEIPDFSKK IITPCELFIA YGYVDWHCNY LFEFFNLLAV PSVRSALDGL
RGGKYRLWSL GWGAPSLVDV TKGALQSGPS VEGGPSVEGG TTVERGPSVE CTPEPSAPVG
ESPGPSNSLL ECHPLVDPSL PIPPEEQKKF ITTFDERSPM CRYFLETLVE NASREYRGVE
MNYNTETVPE VLPGDDGIAQ RYEADLRFCG
//
