ID A5K280_PLAVS Unreviewed; 959 AA.
AC A5K280;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=N-acetylglucosaminylphosphatidylinositol deacetylase {ECO:0000256|ARBA:ARBA00012176};
DE EC=3.5.1.89 {ECO:0000256|ARBA:ARBA00012176};
GN ORFNames=PVX_114345 {ECO:0000313|EMBL:EDL46530.1};
OS Plasmodium vivax (strain Salvador I).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=126793 {ECO:0000313|EMBL:EDL46530.1, ECO:0000313|Proteomes:UP000008333};
RN [1] {ECO:0000313|EMBL:EDL46530.1, ECO:0000313|Proteomes:UP000008333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Salvador I {ECO:0000313|EMBL:EDL46530.1,
RC ECO:0000313|Proteomes:UP000008333};
RX PubMed=18843361; DOI=10.1038/nature07327;
RA Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E.,
RA Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q., Coulson R.M.,
RA Crabb B.S., Del Portillo H.A., Essien K., Feldblyum T.V.,
RA Fernandez-Becerra C., Gilson P.R., Gueye A.H., Guo X., Kang'a S.,
RA Kooij T.W., Korsinczky M., Meyer E.V., Nene V., Paulsen I., White O.,
RA Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J.,
RA Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J.,
RA Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.;
RT "Comparative genomics of the neglected human malaria parasite Plasmodium
RT vivax.";
RL Nature 455:757-763(2008).
CC -!- SIMILARITY: Belongs to the PIGL family.
CC {ECO:0000256|ARBA:ARBA00006066}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDL46530.1}.
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DR EMBL; AAKM01000003; EDL46530.1; -; Genomic_DNA.
DR RefSeq; XP_001616257.1; XM_001616207.1.
DR AlphaFoldDB; A5K280; -.
DR STRING; 126793.A5K280; -.
DR EnsemblProtists; EDL46530; EDL46530; PVX_114345.
DR GeneID; 5475556; -.
DR KEGG; pvx:PVX_114345; -.
DR InParanoid; A5K280; -.
DR OMA; NFICLMK; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000008333; Chromosome 11.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000225; F:N-acetylglucosaminylphosphatidylinositol deacetylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.10320; LmbE-like; 1.
DR InterPro; IPR003737; GlcNAc_PI_deacetylase-related.
DR InterPro; IPR024078; LmbE-like_dom_sf.
DR PANTHER; PTHR12993:SF11; N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE; 1.
DR PANTHER; PTHR12993; N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED; 1.
DR Pfam; PF02585; PIG-L; 1.
DR SUPFAM; SSF102588; LmbE-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008333};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..959
FT /note="N-acetylglucosaminylphosphatidylinositol
FT deacetylase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002685031"
FT TRANSMEM 937..958
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 40..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 959 AA; 109954 MW; C323C0FE4820C2E9 CRC64;
MMPTMETFTL LLAIVLMLYL NPGDYMSSSD TIGAFEPLSS TNRCSNSANP SRKERGLASA
DDQPSSSTGK SYKSIVEKKR SLSNKRAFVV PDDQPLPTGK YTSVDVHAEE IELDRLPRRK
EFVEPEPIPS TSKAFLEPEP IPSTSKAYVE SNPMPSTSKA ASTEAPFESP FEVPTTDTTS
SRQDRFFRKK PKESKDLIPS YLDSILDSDV LNYYEQNMGS IHSEDMDVEN LFDELCVQTY
VMSAHLMVHG DANQKESAYM SICRDCHHFF VSDKECLDNS INMSIKNDNE KETVIKVPLL
GLRYAKSNKS DQSFLVNFPV TYILSKLTSS VLNMDSYDTK SMSITCDILR KKLERDINEN
LVKFPSDMGI FSDYILSYKK NFKNEMSNNI KDLSDPLHSC KELLRSFENM EILTTSLLNK
SGTKYAEHRA SQKKMESFVF SIFNFNYREY DINVHIKLIY DFSHIIYGII ERVKKVYNND
IKFLFLKDLE TPEFFFLRNN LNIKNICSIN IIATISWFFN QVNMGLYNKN KTVPYLFMKK
FSYKNIEKIV KMESIQKNVP KEYITDLCIN TMAEMVDMVG SALIAYQNDN LSELDEEIDA
AEHARDTSSG RDTPRAQSPV SSSGGDTPRA QSPVSSSGGD TPRAQSPVSY ISLLLSSPLG
HIPYSFSPDP AVPASPPPPQ TRKAVTPKFT FSNIIKYAEM SLLKERLNVL LVEDTSDGGS
SNESQKDIQT LQKNFWAREN FICLMKIFSS KMNFHLSGLQ KSFLQKLTLE NYKSYAILNR
PLDDRNHMYF CSLPGEYLIH KIFSSKKKDL LTWLKEKENV SFVIAHPDDE IMFFFPTIKL
LFEKKKKEEI FLLSLTNGDF YSQGKIREKE LYHVWSYLGG VKNNCKVMND PDVQDGSALW
NDQHLADILA DYCTRCNISN KRFLTFRLMY LYRSQFVYYR ILFCLFSQYA YFNAFDLIS
//
