ID A5K2Q0_PLAVS Unreviewed; 518 AA.
AC A5K2Q0;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Exosome complex exonuclease, putative {ECO:0000313|EMBL:EDL46700.1};
GN ORFNames=PVX_115185 {ECO:0000313|EMBL:EDL46700.1};
OS Plasmodium vivax (strain Salvador I).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=126793 {ECO:0000313|EMBL:EDL46700.1, ECO:0000313|Proteomes:UP000008333};
RN [1] {ECO:0000313|EMBL:EDL46700.1, ECO:0000313|Proteomes:UP000008333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Salvador I {ECO:0000313|EMBL:EDL46700.1,
RC ECO:0000313|Proteomes:UP000008333};
RX PubMed=18843361; DOI=10.1038/nature07327;
RA Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E.,
RA Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q., Coulson R.M.,
RA Crabb B.S., Del Portillo H.A., Essien K., Feldblyum T.V.,
RA Fernandez-Becerra C., Gilson P.R., Gueye A.H., Guo X., Kang'a S.,
RA Kooij T.W., Korsinczky M., Meyer E.V., Nene V., Paulsen I., White O.,
RA Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J.,
RA Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J.,
RA Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.;
RT "Comparative genomics of the neglected human malaria parasite Plasmodium
RT vivax.";
RL Nature 455:757-763(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the RNase PH family.
CC {ECO:0000256|ARBA:ARBA00006678}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDL46700.1}.
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DR EMBL; AAKM01000003; EDL46700.1; -; Genomic_DNA.
DR RefSeq; XP_001616427.1; XM_001616377.1.
DR AlphaFoldDB; A5K2Q0; -.
DR STRING; 126793.A5K2Q0; -.
DR EnsemblProtists; EDL46700; EDL46700; PVX_115185.
DR GeneID; 5475726; -.
DR KEGG; pvx:PVX_115185; -.
DR VEuPathDB; PlasmoDB:PVX_115185; -.
DR InParanoid; A5K2Q0; -.
DR OMA; IPHKKVW; -.
DR PhylomeDB; A5K2Q0; -.
DR Proteomes; UP000008333; Chromosome 11.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000178; C:exosome (RNase complex); IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd11368; RNase_PH_RRP45; 1.
DR Gene3D; 3.30.230.70; GHMP Kinase, N-terminal domain; 1.
DR InterPro; IPR001247; ExoRNase_PH_dom1.
DR InterPro; IPR015847; ExoRNase_PH_dom2.
DR InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR033100; Rrp45.
DR PANTHER; PTHR11097:SF14; EXOSOME COMPLEX COMPONENT RRP45; 1.
DR PANTHER; PTHR11097; EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN; 1.
DR Pfam; PF01138; RNase_PH; 1.
DR Pfam; PF03725; RNase_PH_C; 1.
DR SUPFAM; SSF55666; Ribonuclease PH domain 2-like; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Exonuclease {ECO:0000313|EMBL:EDL46700.1};
KW Hydrolase {ECO:0000313|EMBL:EDL46700.1};
KW Nuclease {ECO:0000313|EMBL:EDL46700.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008333}.
FT DOMAIN 31..155
FT /note="Exoribonuclease phosphorolytic"
FT /evidence="ECO:0000259|Pfam:PF01138"
FT DOMAIN 186..253
FT /note="Exoribonuclease phosphorolytic"
FT /evidence="ECO:0000259|Pfam:PF03725"
FT REGION 430..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 244..278
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 472..492
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 518 AA; 58506 MW; 812CA6130ABC4EF1 CRC64;
MKSCKNNANF FWCNLKKKLR LDGRKFEDSR NISIYFLGEH GNVEVSIGHT KVICKITSEI
VKPFDKRPNE GIIKVNLDID SFTNVNDNSQ ISDECLEIKN LIERILKSSN LLNLESLCII
PHKKVWCLLV NIIVIENDGN LYDSCYLSAY SGLVHYRNNE VTVDSSGNII IEEGETNYTP
LSIHNTPILT TFAYFNCEDI CLIDPSIHEE EFMSSKLSVA LNKNGKLVSI LKPGGSPISY
EKILEAIELA KKRVKSILKI LEDALEEDKH LRNSLKKKNL HIKYSANPVH IKYDDANVQA
KPMVIPPNKS VKNNLNIEKI IKKYEQYIYS QEVKKEEKEK SAQGESTLGD STLTSQYLLN
EELRKLKQER GAKNADEFAY MGKYDDDISD ISSELDTKNE EDFGNADVGK IKRQEFSDAN
SQLHNLKMQR TSGVPKKEMP IPAGSQSTGV IRTANDRIDA PVRANPYFKG LPSFEDDKRS
ISAKKHADSS ALSNDDSSDI DFSVAINQNL KKTKKKKG
//
