ID A5K8R0_PLAVS Unreviewed; 896 AA.
AC A5K8R0;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Cell division protein FtsH, putative {ECO:0000313|EMBL:EDL44206.1};
GN ORFNames=PVX_100935 {ECO:0000313|EMBL:EDL44206.1};
OS Plasmodium vivax (strain Salvador I).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=126793 {ECO:0000313|EMBL:EDL44206.1, ECO:0000313|Proteomes:UP000008333};
RN [1] {ECO:0000313|EMBL:EDL44206.1, ECO:0000313|Proteomes:UP000008333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Salvador I {ECO:0000313|EMBL:EDL44206.1,
RC ECO:0000313|Proteomes:UP000008333};
RX PubMed=18843361; DOI=10.1038/nature07327;
RA Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E.,
RA Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q., Coulson R.M.,
RA Crabb B.S., Del Portillo H.A., Essien K., Feldblyum T.V.,
RA Fernandez-Becerra C., Gilson P.R., Gueye A.H., Guo X., Kang'a S.,
RA Kooij T.W., Korsinczky M., Meyer E.V., Nene V., Paulsen I., White O.,
RA Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J.,
RA Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J.,
RA Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.;
RT "Comparative genomics of the neglected human malaria parasite Plasmodium
RT vivax.";
RL Nature 455:757-763(2008).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: In the C-terminal section; belongs to the peptidase M41
CC family. {ECO:0000256|ARBA:ARBA00010044}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the AAA ATPase
CC family. {ECO:0000256|ARBA:ARBA00010550}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDL44206.1}.
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DR EMBL; AAKM01000010; EDL44206.1; -; Genomic_DNA.
DR RefSeq; XP_001613933.1; XM_001613883.1.
DR AlphaFoldDB; A5K8R0; -.
DR STRING; 126793.A5K8R0; -.
DR EnsemblProtists; EDL44206; EDL44206; PVX_100935.
DR GeneID; 5473214; -.
DR KEGG; pvx:PVX_100935; -.
DR VEuPathDB; PlasmoDB:PVX_100935; -.
DR InParanoid; A5K8R0; -.
DR OMA; CFGFAIW; -.
DR PhylomeDB; A5K8R0; -.
DR Proteomes; UP000008333; Chromosome 14.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd19501; RecA-like_FtsH; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.58.760; Peptidase M41; 1.
DR HAMAP; MF_01458; FtsH; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR005936; FtsH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000642; Peptidase_M41.
DR InterPro; IPR037219; Peptidase_M41-like.
DR PANTHER; PTHR23076:SF97; ATP-DEPENDENT ZINC METALLOPROTEASE FTSH 2, CHLOROPLASTIC-RELATED; 1.
DR PANTHER; PTHR23076; METALLOPROTEASE M41 FTSH; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF01434; Peptidase_M41; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF140990; FtsH protease domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:EDL44206.1};
KW Cell division {ECO:0000313|EMBL:EDL44206.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000008333};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 79..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 193..334
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 122..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..660
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..720
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..774
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 778..792
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 813..827
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 896 AA; 99691 MW; AF0D1AB5F37A15C6 CRC64;
MFKHYENAVK RIMNAKYENE SLASTGSEKN GDEENSALLQ NNEATGMNKK KSKKTNNDNR
KYKYYENFFN KKRNKKWNYF MIFFLGICFG FAIWPFFMTI ITYKLFYKDN FNSSNFNTSN
TSASLKPYGN DRSKKGENGK VSVKDQSQKN SSPHFRPIRF EEIAGIDESK LELLEVVDFI
RNREKYQEMG ARMPKGVLLV GPPGSGKTML ARAVATEANV PYIYTSGPEF IEIYVGQGAK
RIRQLFAHAR SVAPSIVFID EIDAIGGKRS SGSVNGAGQR EHDQTLNQLL VEMDGFSNSI
HIMVIGATNR IDTLDSALLR PGRFDRIVYV PLPDVNGRKR ILEIYIKKIK SDLKAEDIDK
IARLTPGFSG ADLENVVNEA TILATRNKKS VVTIGELFEA RDKVSMGPER KSLRQSDHQR
RITAYHEAGH AIVAYFLQPK TDPIHKATII SRGNALGYVE QIPVDDRHNY FKSQMEAKLA
VCMGGRTAEE IVFGKSETSS GASSDISRAT EIAYKMVTEW GMSDKLGPLN YKKRMGDGYS
SNRLSAQTIS TIEVEVKALV EKGKSLSEEI LRRHRKELDN LAFALLDRET LSGEEIKKII
DPNNTRDYSG KVPVLSKGSK SDGAASGPEN EKREGNSTRG GGGSANGSQP NESRSNEGLP
NEGLPNVGLP NVGLPNDRQE VKQADKGTPA EELKRASSDH VLKKKGKRGE REKHGHAPTT
DNGKIEIVRK SAKNAVKKIR KKYAKDPNVK NKKILKVVNE HKPYDADRKA AGGNFQNEHG
RNGKNGLNGA NDPNGPNDPL GKLDKRSYPK GPSPDGGNNN SVVKNMSEVL SKEFAPPYEQ
NGDNESPDFV KAKELTLNNF KEAVDTSHIK NVGEMKKFNI FEHNLGKLFL FDIFGS
//
