ID A5KJD8_9FIRM Unreviewed; 157 AA.
AC A5KJD8;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=precorrin-2 dehydrogenase {ECO:0000256|ARBA:ARBA00012400};
DE EC=1.3.1.76 {ECO:0000256|ARBA:ARBA00012400};
GN ORFNames=RUMTOR_00336 {ECO:0000313|EMBL:EDK25441.1};
OS [Ruminococcus] torques ATCC 27756.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Mediterraneibacter.
OX NCBI_TaxID=411460 {ECO:0000313|EMBL:EDK25441.1, ECO:0000313|Proteomes:UP000003577};
RN [1] {ECO:0000313|EMBL:EDK25441.1, ECO:0000313|Proteomes:UP000003577}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27756 {ECO:0000313|EMBL:EDK25441.1,
RC ECO:0000313|Proteomes:UP000003577};
RA Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA Thiruvilangam P., Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EDK25441.1, ECO:0000313|Proteomes:UP000003577}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27756 {ECO:0000313|EMBL:EDK25441.1,
RC ECO:0000313|Proteomes:UP000003577};
RA Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA Gordon J.;
RT "Draft genome sequence of Ruminococcus torques (ATCC 27756).";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin;
CC Xref=Rhea:RHEA:15613, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945, ChEBI:CHEBI:58351, ChEBI:CHEBI:58827; EC=1.3.1.76;
CC Evidence={ECO:0000256|ARBA:ARBA00001156};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; siroheme
CC biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005010}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDK25441.1}.
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DR EMBL; AAVP02000001; EDK25441.1; -; Genomic_DNA.
DR RefSeq; WP_004845520.1; NZ_DS264345.1.
DR AlphaFoldDB; A5KJD8; -.
DR PaxDb; 411460-RUMTOR_00336; -.
DR HOGENOM; CLU_011276_8_3_9; -.
DR UniPathway; UPA00262; UER00222.
DR Proteomes; UP000003577; Unassembled WGS sequence.
DR GO; GO:0004325; F:ferrochelatase activity; IEA:InterPro.
DR GO; GO:0043115; F:precorrin-2 dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR028161; Met8-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006367; Sirohaem_synthase_N.
DR NCBIfam; TIGR01470; cysG_Nterm; 1.
DR PANTHER; PTHR35330; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR PANTHER; PTHR35330:SF1; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR Pfam; PF13241; NAD_binding_7; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
SQ SEQUENCE 157 AA; 17880 MW; 9716F2D84A9E7E13 CRC64;
MKKPYFPMFV DLSGRQVTVV GGGSVALRRS ETLLYFGVDI KVIAPEIRSE FYRLDSEGKV
VLCNREYQEG DAKGADLVIA ASNCREVNRR VYEECQKAHI PVNTADDREL CDFYFPSVVL
AEDIVIGLNS IDHDPKKVKE ARKIIENVFD NERDYRS
//
