ID   A5L8N1_VIBBS            Unreviewed;       342 AA.
AC   A5L8N1;
DT   10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   10-JUL-2007, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   SubName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase {ECO:0000313|EMBL:EDK25925.1};
GN   ORFNames=VSWAT3_23899 {ECO:0000313|EMBL:EDK25925.1};
OS   Vibrionales bacterium (strain SWAT-3).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales.
OX   NCBI_TaxID=391574 {ECO:0000313|EMBL:EDK25925.1, ECO:0000313|Proteomes:UP000004912};
RN   [1] {ECO:0000313|EMBL:EDK25925.1, ECO:0000313|Proteomes:UP000004912}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SWAT-3 {ECO:0000313|EMBL:EDK25925.1,
RC   ECO:0000313|Proteomes:UP000004912};
RA   Azam F., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G.,
RA   Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the vitamin-B12 independent methionine synthase
CC       family. {ECO:0000256|ARBA:ARBA00009553}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EDK25925.1}.
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DR   EMBL; AAZW01000108; EDK25925.1; -; Genomic_DNA.
DR   AlphaFoldDB; A5L8N1; -.
DR   Proteomes; UP000004912; Unassembled WGS sequence.
DR   GO; GO:0003871; F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd03311; CIMS_C_terminal_like; 1.
DR   Gene3D; 3.20.20.210; -; 1.
DR   InterPro; IPR002629; Met_Synth_C/arc.
DR   InterPro; IPR016456; Met_Synthase_cat.
DR   InterPro; IPR038071; UROD/MetE-like_sf.
DR   PANTHER; PTHR30519; 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR30519:SF0; 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE; 1.
DR   Pfam; PF01717; Meth_synt_2; 1.
DR   PIRSF; PIRSF005632; Met_synth_catalytic_prd; 1.
DR   SUPFAM; SSF51726; UROD/MetE-like; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Methyltransferase {ECO:0000313|EMBL:EDK25925.1};
KW   Transferase {ECO:0000313|EMBL:EDK25925.1};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          5..330
FT                   /note="Cobalamin-independent methionine synthase MetE C-
FT                   terminal/archaeal"
FT                   /evidence="ECO:0000259|Pfam:PF01717"
SQ   SEQUENCE   342 AA;  38408 MW;  44C698B3B37A9DBC CRC64;
     MKTLLPTSTA GSLPKPSWLA QPETLWSPWK LEGDELTDGK QDALRVSLHE QQQAGIDIVS
     DGEQTRQHFV TTFIEHLNGV DFEKRATVKI RDRYDASVPT VVGPVSRQKS VFVEDAKFLR
     QQTDQPIKWA LPGPMTMIDT LYDAHYQSRE KLAWEFAKIL NEEAKELEAA GVDIIQFDEP
     AFNVFFDEVN DWGIACLERA IEGLKCETAV HICYGYGIKA NTDWKKTLGT EWRQYEEVFP
     KLQQSNIDII SLECHNSHVP LELLELVRGK KVMVGAIDVA TDSIETPEEV ASTLRETLKY
     VDADKLYPCT NCGMAPLPRE IASAKLNALS AGAEIVRKEL SA
//