ID A5PJF9_BOVIN Unreviewed; 471 AA.
AC A5PJF9;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 127.
DE SubName: Full=UEV and lactate/malate dehyrogenase domains {ECO:0000313|Ensembl:ENSBTAP00000018040.4};
DE SubName: Full=UEVLD protein {ECO:0000313|EMBL:AAI42096.1};
GN Name=UEVLD {ECO:0000313|EMBL:AAI42096.1,
GN ECO:0000313|Ensembl:ENSBTAP00000018040.4,
GN ECO:0000313|VGNC:VGNC:36643};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI42096.1};
RN [1] {ECO:0000313|EMBL:AAI42096.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hereford {ECO:0000313|EMBL:AAI42096.1};
RC TISSUE=Heart ventrical {ECO:0000313|EMBL:AAI42096.1};
RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA Holt R., Jones S.J., Marra M.A.;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000018040.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000018040.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSBTAP00000018040.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000018040.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BC142095; AAI42096.1; -; mRNA.
DR RefSeq; NP_001092422.1; NM_001098952.1.
DR STRING; 9913.ENSBTAP00000018040; -.
DR PaxDb; 9913-ENSBTAP00000018040; -.
DR Ensembl; ENSBTAT00000018040.5; ENSBTAP00000018040.4; ENSBTAG00000013568.5.
DR GeneID; 512846; -.
DR KEGG; bta:512846; -.
DR CTD; 55293; -.
DR VEuPathDB; HostDB:ENSBTAG00000013568; -.
DR VGNC; VGNC:36643; UEVLD.
DR eggNOG; KOG1495; Eukaryota.
DR eggNOG; KOG2391; Eukaryota.
DR GeneTree; ENSGT00940000153903; -.
DR HOGENOM; CLU_039842_0_1_1; -.
DR OMA; CIMGANG; -.
DR TreeFam; TF314963; -.
DR Proteomes; UP000009136; Chromosome 29.
DR Bgee; ENSBTAG00000013568; Expressed in spermatid and 107 other cell types or tissues.
DR GO; GO:0000813; C:ESCRT I complex; IBA:GO_Central.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR GO; GO:0008333; P:endosome to lysosome transport; IBA:GO_Central.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:InterPro.
DR CDD; cd05293; LDH_1; 1.
DR Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR001557; L-lactate/malate_DH.
DR InterPro; IPR022383; Lactate/malate_DH_C.
DR InterPro; IPR001236; Lactate/malate_DH_N.
DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR008883; UEV_N.
DR PANTHER; PTHR43128; L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)); 1.
DR PANTHER; PTHR43128:SF32; UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 3; 1.
DR Pfam; PF02866; Ldh_1_C; 1.
DR Pfam; PF00056; Ldh_1_N; 1.
DR Pfam; PF05743; UEV; 1.
DR PRINTS; PR00086; LLDHDRGNASE.
DR SMART; SM00212; UBCc; 1.
DR SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS51322; UEV; 1.
PE 2: Evidence at transcript level;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 2..145
FT /note="UEV"
FT /evidence="ECO:0000259|PROSITE:PS51322"
SQ SEQUENCE 471 AA; 52237 MW; 288A7724AA06A774 CRC64;
MEFDSEALRR LLGKYKFRDL TVEELKNVNM FFPHFRYSMD TYVFKDSSQK DLLNFTGTIP
VIYQGNTYNI PIRLWILDSH PFAPPICFLK PTANMGILVG KHVDAQGRIY LPYLQNWSHP
KSVIVGLIKE MIAKFQDELP LCSLSSSDEA RQVDLLAYIA KITEGVSDIN SKNWANRENK
TVNKITVVGG GELGIACTLA ISAKGIADKL VLLDFSEGTK GGMMDLDIFN LPNVEISKDL
SASAHSKVVI FTVNSLGSSQ SYLDVVQSNV DMFRALVPAL GHYSQHAILL VASQPVEIMT
YVTWKLSAFP ANRVIGIGCN LDSQRLQYII TNVLKAQTSG KEVWVIGEQG EDKVPIWSGQ
EEVTNHDSQM QLSNRAMELL RVKGQRSWSV GLSVADLLDS IVNDKKKVHS VSILAKGYYD
INSEVFLSLP CILGTSGVSE VIKTTVKEET VTEKLQSSAS SIHGLQQQLK L
//
