ID A5PJW4_BOVIN Unreviewed; 379 AA.
AC A5PJW4;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 24-JAN-2024, entry version 115.
DE SubName: Full=Pregnancy-associated glycoprotein 6 {ECO:0000313|EMBL:AAI42264.1, ECO:0000313|Ensembl:ENSBTAP00000038685.2};
GN Name=PAG6 {ECO:0000313|EMBL:AAI42264.1,
GN ECO:0000313|Ensembl:ENSBTAP00000038685.2};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI42264.1};
RN [1] {ECO:0000313|EMBL:AAI42264.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hereford {ECO:0000313|EMBL:AAI42264.1};
RC TISSUE=Placenta {ECO:0000313|EMBL:AAI42264.1};
RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA Holt R., Jones S.J., Marra M.A.;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000038685.2, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000038685.2,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSBTAP00000038685.2}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000038685.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR EMBL; BC142263; AAI42264.1; -; mRNA.
DR SMR; A5PJW4; -.
DR STRING; 9913.ENSBTAP00000038685; -.
DR MEROPS; A01.089; -.
DR PaxDb; 9913-ENSBTAP00000038685; -.
DR Ensembl; ENSBTAT00000038878.3; ENSBTAP00000038685.2; ENSBTAG00000006304.5.
DR VEuPathDB; HostDB:ENSBTAG00000006304; -.
DR eggNOG; KOG1339; Eukaryota.
DR GeneTree; ENSGT00940000153747; -.
DR HOGENOM; CLU_013253_3_0_1; -.
DR OMA; STKTLWN; -.
DR Proteomes; UP000009136; Chromosome 29.
DR Bgee; ENSBTAG00000006304; Expressed in placenta and 4 other cell types or tissues.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR Gene3D; 6.10.140.60; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR012848; Aspartic_peptidase_N.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF49; PEPSIN A-5; 1.
DR Pfam; PF07966; A1_Propeptide; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 2.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 2: Evidence at transcript level;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..379
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015086506"
FT DOMAIN 70..376
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 88
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 269
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 101..106
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 260..264
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 302..336
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 379 AA; 42707 MW; 00DBEBF84ECDB938 CRC64;
MKWLVLLGLV AFSECIVKIP LRRVKTMRNA ISGKNTLNNI LKEHAYRLPQ ISFRGSNLTH
PLRNIRDLFY VGNITIGTPP QEFQVIFDTG SSDLWVASIF CNSSSCAAHV RFRHHQSSTF
RPTNKTFRIT YGSGRMKGVV VHDTVRIGDL VSTDQPFGLC LKDSGFKGIP FDGILGLSYP
NKTFSGAFPI FDKLKNEGAI SEPVFAFYLS KDKQEGSVVM FGGVDHRYYK GELNWVPLIQ
VGDWFVHMDR ITMKRKVIAC SDGCKALVDT GTSDIVGPST LVNNIWKLIR ARPLGPQYFV
SCSAVNTLPS IIFTINGINY RLPARAYIHK DSRGRCYTAF KEHRFSSPIE TWLLGDVFLR
RYFSVFDRGN DRIGLARAV
//