GenomeNet

Database: UniProt
Entry: A5TYS7_MYCTA
LinkDB: A5TYS7_MYCTA
Original site: A5TYS7_MYCTA 
ID   A5TYS7_MYCTA            Unreviewed;       966 AA.
AC   A5TYS7;
DT   10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   10-JUL-2007, sequence version 1.
DT   24-JAN-2024, entry version 71.
DE   SubName: Full=Membrane protein MmpL11 {ECO:0000313|EMBL:ABQ71927.1};
GN   Name=mmpL11 {ECO:0000313|EMBL:ABQ71927.1};
GN   OrderedLocusNames=MRA_0210 {ECO:0000313|EMBL:ABQ71927.1};
OS   Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=419947 {ECO:0000313|EMBL:ABQ71927.1, ECO:0000313|Proteomes:UP000001988};
RN   [1] {ECO:0000313|EMBL:ABQ71927.1, ECO:0000313|Proteomes:UP000001988}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25177 / H37Ra {ECO:0000313|Proteomes:UP000001988};
RX   PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA   Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA   Wang H., Wang S., Zhao G., Zhang Y.;
RT   "Genetic basis of virulence attenuation revealed by comparative genomic
RT   analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL   PLoS ONE 3:E2375-E2375(2008).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000611; ABQ71927.1; -; Genomic_DNA.
DR   RefSeq; WP_003401190.1; NZ_CP016972.1.
DR   AlphaFoldDB; A5TYS7; -.
DR   SMR; A5TYS7; -.
DR   KEGG; mra:MRA_0210; -.
DR   eggNOG; COG2409; Bacteria.
DR   HOGENOM; CLU_005108_2_0_11; -.
DR   OMA; HWSRRPE; -.
DR   Proteomes; UP000001988; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN YDFJ; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001988};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        184..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        207..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        232..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        275..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        311..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        370..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        526..545
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        557..578
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        598..618
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        639..662
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        668..695
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          207..332
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   966 AA;  103502 MW;  3E8BF0327CBEA2DA CRC64;
     MMRLSRNLRR CRWLVFTGWL LALVPAVYLA MTQSGNLTGG GFEVAGSQSL LVHDQLDAHY
     PDRGAPALAL VAAPRPDASY QDIDNAVALL RQIASELPGV TEAPNPTQRP PQPDRPYVVS
     LRLDARNAGT SDVAKKLRDR IGVKGDQSGQ TANGKVRLYV IGQGALSAAA AANTKHDIAN
     AERWNLPIIL MVLVAVFGSL AAAAIPLALA VCTVVITMGL VFVLSMHTTM SVFVTSTVSM
     FGIALAVDYS LFILMRYREE LRCGRRPPDA VDAAMATSGL AVVLSGMTVI ASLTGIYLIN
     TPALRSMATG AILAVAVAML TSATLTPAVL ATFARAAAKR SALVHWSRRP ASTQSWFWSR
     WVGWVMRRPW ITALAASTVL LVMAAPATLM VLGNSLLRQF DSSHEIRTGA AAAAQALGPG
     ALGPVQVLVR FDAGGASAPE HSQTIAAIRH RIAQAPNVVS VAPPRFADDN GSALLSAVLS
     VDPEDLGARD TITWMRTQLP RVAGAAQVDV GGPTALIKDF DDRVSATQPL VLVFVAVIAF
     LMLLISIRSV FLAFKGVLMT LLSVAAAYGS LVMVFQWGWA RGLGFPALHS IDSTVPPLVL
     AMTFGLSMDY EIFLLTRIRE RFLQTGQTRD AVAYGVRTSA RTITSAALIM IAVFCGFAFA
     GMPLVAEIGV ACAVAIAVDA TVVRLVLVPA LMAMFDRWNW WLPRWLAHIL PSVDFDRPLP
     KVDLGDVVVI PDDFAAAIPP SADVRMVLKS AAKLKRLAPD AICVTDPLAF TGCGCDGKAL
     DQVQLAYRNG IARAISWGQR PVHPVTVWRK RLAVALDALQ TTTWECGGVQ THRAGPGYRR
     RSPVETTNVA LPTGDRLQIP TGAETLRFKG YLIMSRNSSH DYADFADLVD TMAPETAAAV
     LAGMDRYYSC QAPGRQWMAT QLVGRLADPQ PSDLGDQSPG ADAQAKWEEV RRRCLSVAVA
     MLEEAR
//
DBGET integrated database retrieval system