ID A5TZU5_MYCTA Unreviewed; 486 AA.
AC A5TZU5;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Monooxygenase {ECO:0000313|EMBL:ABQ72295.1};
GN OrderedLocusNames=MRA_0572 {ECO:0000313|EMBL:ABQ72295.1};
OS Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=419947 {ECO:0000313|EMBL:ABQ72295.1, ECO:0000313|Proteomes:UP000001988};
RN [1] {ECO:0000313|EMBL:ABQ72295.1, ECO:0000313|Proteomes:UP000001988}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25177 / H37Ra {ECO:0000313|Proteomes:UP000001988};
RX PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA Wang H., Wang S., Zhao G., Zhang Y.;
RT "Genetic basis of virulence attenuation revealed by comparative genomic
RT analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL PLoS ONE 3:E2375-E2375(2008).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the FAD-binding monooxygenase family.
CC {ECO:0000256|ARBA:ARBA00010139}.
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DR EMBL; CP000611; ABQ72295.1; -; Genomic_DNA.
DR RefSeq; WP_003402981.1; NZ_CP016972.1.
DR AlphaFoldDB; A5TZU5; -.
DR SMR; A5TZU5; -.
DR KEGG; mra:MRA_0572; -.
DR eggNOG; COG2072; Bacteria.
DR HOGENOM; CLU_032067_2_0_11; -.
DR Proteomes; UP000001988; Chromosome.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0004499; F:N,N-dimethylaniline monooxygenase activity; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR020946; Flavin_mOase-like.
DR PANTHER; PTHR43872; MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED; 1.
DR PANTHER; PTHR43872:SF1; MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED; 1.
DR Pfam; PF00743; FMO-like; 1.
DR PRINTS; PR00411; PNDRDTASEI.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Monooxygenase {ECO:0000313|EMBL:ABQ72295.1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001988}.
SQ SEQUENCE 486 AA; 54526 MW; 8A789FC6B8B2423B CRC64;
MSVTPNAGCV DVVIVGAGIS GLGAAYRIIE RNPQLTYTIL ERRARIGGTW DLFRYPGVRS
DSSIFTLSFP YEPWTREEGI ADGAHIREYL TDMAHKYGID RHIEFNSYVR AADWDSSTDT
WTVTFEQNGV HKHYRSRFVF FGSGYYNYDE GYTPDFGGIE KFGGAVVHPQ HWPEDLDYTG
KKIVVIGSGA TAVTLIPSLT DRAEKVTMLQ RSPTYLISAS KYSTFAAVVR KALPPKTSHL
IVRMYNALLE AVFWFLSRKT PVFVKWLLRR TAIKNLPEGY DIETHFTPRY NPWDQRLCLI
PDADLYNAIT SGRAEVVTDH IDHFDATGIA LKSGGHLDAD IIVTATGLQL QALGGAAISL
DGVEIDPRDR FVYKAHMLED VPNLFWCVGY TNASWTLRAD MTARATAKLL AHMAAHGHTR
AAPHLGDEPM DEKPSWDIQA GYVKRAPYAL PKSGTKRPWN VRQNYLADAI DYRFDRIEEA
MVFGAA
//
