ID A5U7I6_MYCTA Unreviewed; 448 AA.
AC A5U7I6;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Flavin-containing amine oxidase {ECO:0000313|EMBL:ABQ74986.1};
GN Name=aofH {ECO:0000313|EMBL:ABQ74986.1};
GN OrderedLocusNames=MRA_3203 {ECO:0000313|EMBL:ABQ74986.1};
OS Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=419947 {ECO:0000313|EMBL:ABQ74986.1, ECO:0000313|Proteomes:UP000001988};
RN [1] {ECO:0000313|EMBL:ABQ74986.1, ECO:0000313|Proteomes:UP000001988}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25177 / H37Ra {ECO:0000313|Proteomes:UP000001988};
RX PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA Wang H., Wang S., Zhao G., Zhang Y.;
RT "Genetic basis of virulence attenuation revealed by comparative genomic
RT analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL PLoS ONE 3:E2375-E2375(2008).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the flavin monoamine oxidase family.
CC {ECO:0000256|ARBA:ARBA00005995}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000611; ABQ74986.1; -; Genomic_DNA.
DR RefSeq; WP_003416607.1; NZ_CP016972.1.
DR AlphaFoldDB; A5U7I6; -.
DR SMR; A5U7I6; -.
DR KEGG; mra:MRA_3203; -.
DR eggNOG; COG1231; Bacteria.
DR HOGENOM; CLU_004498_0_4_11; -.
DR Proteomes; UP000001988; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.660.10; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.10.405.10; Guanine Nucleotide Dissociation Inhibitor, domain 1; 1.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR001613; Flavin_amine_oxidase.
DR PANTHER; PTHR43563; AMINE OXIDASE; 1.
DR PANTHER; PTHR43563:SF1; FLAVIN-CONTAINING MONOAMINE OXIDASE B-RELATED; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR PRINTS; PR00757; AMINEOXDASEF.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001988}.
FT DOMAIN 17..444
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
SQ SEQUENCE 448 AA; 48440 MW; 93FA2C74B3F13D7A CRC64;
MTNPPWTVDV VVVGAGFAGL AAARELTRQG HEVLVFEGRD RVGGRSLTGR VAGVPADMGG
SFIGPTQDAV LALATELGIP TTPTHRDGRN VIQWRGSARS YRGTIPKLSL TGLIDIGRLR
WQFERIARGV PVAAPWDARR ARELDDVSLG EWLRLVRATS SSRNLMAIMT RVTWGCEPDD
VSMLHAARYV RAAGGLDRLL DVKNGAQQDR VPGGTQQIAQ AAAAQLGARV LLNAAVRRID
RHGAGVTVTS DQGQAEAGFV IVAIPPAHRV AIEFDPPLPP EYQQLAHHWP QGRLSKAYAA
YSTPFWRASG YSGQALSDEA PVFITFDVSP HADGPGILMG FVDARGFDSL PIEERRRDAL
RCFASLFGDE ALDPLDYVDY RWGTEEFAPG GPTAAVPPGS WTKYGHWLRE PVGPIHWAST
ETADEWTGYF DGAVRSGQRA AAEVAALL
//
