GenomeNet

Database: UniProt
Entry: A5UD28
LinkDB: A5UD28
Original site: A5UD28 
ID   PYRG_HAEIE              Reviewed;         545 AA.
AC   A5UD28;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   11-JUN-2014, entry version 56.
DE   RecName: Full=CTP synthase;
DE            EC=6.3.4.2;
DE   AltName: Full=CTP synthetase;
DE   AltName: Full=UTP--ammonia ligase;
GN   Name=pyrG; OrderedLocusNames=CGSHiEE_06690;
OS   Haemophilus influenzae (strain PittEE).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=374930;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PittEE;
RX   PubMed=17550610; DOI=10.1186/gb-2007-8-6-r103;
RA   Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R.,
RA   Post J.C., Ehrlich G.D.;
RT   "Characterization and modeling of the Haemophilus influenzae core and
RT   supragenomes based on the complete genomic sequences of Rd and 12
RT   clinical nontypeable strains.";
RL   Genome Biol. 8:R103.1-R103.18(2007).
CC   -!- FUNCTION: Catalyzes the ATP-dependent amination of UTP to CTP with
CC       either L-glutamine or ammonia as the source of nitrogen (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + UTP + L-glutamine = ADP + phosphate +
CC       CTP + L-glutamate.
CC   -!- ENZYME REGULATION: Allosterically activated by GTP, when glutamine
CC       is the substrate. Inhibited by CTP (By similarity).
CC   -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via de novo
CC       pathway; CTP from UDP: step 2/2.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SIMILARITY: Belongs to the CTP synthase family.
CC   -!- SIMILARITY: Contains 1 glutamine amidotransferase type-1 domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000671; ABQ98679.1; -; Genomic_DNA.
DR   RefSeq; YP_001291062.1; NC_009566.1.
DR   ProteinModelPortal; A5UD28; -.
DR   SMR; A5UD28; 1-542.
DR   STRING; 374930.CGSHiEE_06690; -.
DR   EnsemblBacteria; ABQ98679; ABQ98679; CGSHiEE_06690.
DR   GeneID; 5225847; -.
DR   KEGG; hip:CGSHiEE_06690; -.
DR   PATRIC; 20278829; VBIHaeInf81350_1349.
DR   eggNOG; COG0504; -.
DR   HOGENOM; HOG000077515; -.
DR   KO; K01937; -.
DR   OMA; SVNIKYI; -.
DR   OrthoDB; EOG6RC3NR; -.
DR   BioCyc; HINF374930:GJDD-1243-MONOMER; -.
DR   UniPathway; UPA00159; UER00277.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003883; F:CTP synthase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0044210; P:'de novo' CTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.40.50.880; -; 1.
DR   HAMAP; MF_01227; PyrG; 1.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR004468; CTP_synthase.
DR   InterPro; IPR017456; CTP_synthase_N.
DR   InterPro; IPR017926; GATASE.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11550; PTHR11550; 1.
DR   Pfam; PF06418; CTP_synth_N; 1.
DR   Pfam; PF00117; GATase; 1.
DR   SUPFAM; SSF52317; SSF52317; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00337; PyrG; 1.
DR   PROSITE; PS51273; GATASE_TYPE_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Glutamine amidotransferase; Ligase;
KW   Nucleotide-binding; Pyrimidine biosynthesis.
FT   CHAIN         1    545       CTP synthase.
FT                                /FTId=PRO_1000139467.
FT   DOMAIN      291    542       Glutamine amidotransferase type-1.
FT   REGION        1    253       Aminator domain.
FT   ACT_SITE    379    379       Nucleophile (By similarity).
FT   ACT_SITE    515    515       By similarity.
FT   ACT_SITE    517    517       By similarity.
SQ   SEQUENCE   545 AA;  60212 MW;  938EB38676B1C635 CRC64;
     MATNYIFVTG GVVSSLGKGI AAASLAAILE ARGLNVTIMK LDPYINVDPG TMSPTQHGEV
     FVTQDGAETD LDLGHYERFI RTKMTKRNNF TTGKIYSEVL RKERRGDYLG ATIQVIPHIT
     NEIKDRVIAG AQGHDVVIVE VGGTVGDIES LPFLEALRQL AVQVGREHTL FMHLTLVPYI
     PTAGEVKTKP TQHSVKELLS IGIQPDVLIC RSDRMIPPNE RAKIALFCNV AERAVISLKD
     VNSIYQIPAL LKSQGLDDFV CERFRLTCPE ADLTEWEQVL YKQANPVGEV TIGMVGKYTE
     LPDAYKSVNE ALKHAGLTNR LSVSIKYIDS QDVETKGVEV LKGVDGILVP GGFGYRGVEG
     KIRTAQYARE NKIPYLGICL GMQIALIEYA RNVAGLTKAN SSEFDKDCEQ PVVALITEWQ
     DAEGNTEVRT DESDLGGTMR LGAQQCHLVS GSRARELYGK ETIEERHRHR YEVNNTLLPQ
     IEKAGLKVTG LSADKKLVEI IEVPNHPWFV ACQFHPEFTS TPRDGHPLFA GFVKAAYENH
     KKSVK
//
DBGET integrated database retrieval system