ID A5UWB1_ROSS1 Unreviewed; 1243 AA.
AC A5UWB1;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=RoseRS_2538 {ECO:0000313|EMBL:ABQ90914.1};
OS Roseiflexus sp. (strain RS-1).
OC Bacteria; Chloroflexota; Chloroflexia; Chloroflexales; Roseiflexineae;
OC Roseiflexaceae; Roseiflexus.
OX NCBI_TaxID=357808 {ECO:0000313|EMBL:ABQ90914.1, ECO:0000313|Proteomes:UP000006554};
RN [1] {ECO:0000313|Proteomes:UP000006554}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS-1 {ECO:0000313|Proteomes:UP000006554};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Bryant D.A., Richardson P.;
RT "Complete sequence of Roseiflexus sp. RS-1.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP000686; ABQ90914.1; -; Genomic_DNA.
DR RefSeq; WP_011957258.1; NC_009523.1.
DR AlphaFoldDB; A5UWB1; -.
DR STRING; 357808.RoseRS_2538; -.
DR REBASE; 15606; RspRSORF2538P.
DR KEGG; rrs:RoseRS_2538; -.
DR eggNOG; COG1002; Bacteria.
DR HOGENOM; CLU_004385_0_0_0; -.
DR OrthoDB; 9815272at2; -.
DR Proteomes; UP000006554; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR046820; MmeI_TRD.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR Pfam; PF20466; MmeI_TRD; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 451..570
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 772..878
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT DOMAIN 938..1119
FT /note="MmeI-like target recognition"
FT /evidence="ECO:0000259|Pfam:PF20466"
SQ SEQUENCE 1243 AA; 136288 MW; 06377BAF508E70B7 CRC64;
MSHIHAPTPA IRLEGGLLGP DILDAALAGD LPGQQPRDFG LDGSRSLTDE IAGAFADAQA
QWALFRRRLA RLPDDDPATA ITRDAWVIPF LSLLGYDLHA NPHPYAIDGA RFAISHRAGA
ADDAPPVHIV GVRQDLGRVP PAPSRTGGVR MAPHVLVQEY LNRSEQVWGL VANGRTLRLL
RNSTYLRRQA YVECDLAQIL DEQRFADFAA LYRLIHRTRL PQTAADARDC WLERYHQHAL
EQGGRVRDRL RDGVEQALLI LANGFLAHPA NGALRAALRL PPPGEPVPDD VAAALYRQAL
RIVYRVLFLL TAEDRGLISD DPHYAHYGVG RLRRLLTRRS AFTDHVDLWL GFQTLRQIVS
DAALAALLGA APLNGDLFAP VDLDAAVITN RDLLHAFRHL AWYGDPPRRI NYAALDTEEL
GSVYESLLEL HPTIAWRGAV PVVAFAARSA ERRATGSHYT PPELVAPLVQ HALEPALRAR
LAPCPTPAER EAALLGLTVL DPACGSGHFL LAAARHLGTE LARIRSGDAA PAPEIVRDAV
RDVIAHCLYG VDKNPLAVEL CRVALWLEGH ARGRPLTFLD HRIRCGDSLL GVADLQALEA
GIPDDAYRPL GTDDRAHARQ VKARNAREAR MDLFRHGFVT APLADLAAQM HQVAAMPDRT
VEQVHAKSAA YRRVITQDAY RRLRLACDVW TAAFFQSFAP PQSPPPTPHA RGGGMGVVGV
ALTTMAVQEA LTHGALSDPR QGAFVTVTRD ERAFFHWSLE FPDAAAAGGF DVILGNPPFM
GGLRISGVAG EAYRRWLEAA LVPFGGTADL CAAFFRRAFA LLRPGGRLGM IATNTIGQGD
TRESGLKVIL AQGGRIAFAR RFVRWPGQAS VEVNLVVIEA PRARRTQEGT GGDGGALLDD
HPVAAISSRL DAEPDGEPAR LRQNDGKAFI GDFVRGLGFV LEAAEAEALL ARDPRNADCL
FPYLNGDDLN THPAQQPGRW VICFHDWDLA RAQQYPDLLR IVEERVKPER EGLRGPGDAR
NRAAWWQFGA YRAGMRHAIA PLRRVLARSR ISEMHAPVFV PKGWIYNEQL VVFAFDDDYH
FALLQSGVHE AWARRQASSL RTDLRYTPTD CFATFPFPPA EDAAPDLARV LAHPAFAHAA
QIGAAYHERR REVMQARRIG LTKTYNLLHD PACLDADIAD LRRLHAALDA AILACYGWDD
LDPGHDFHAN ARGQTRFGMA PAVQRAVVQR LLDLNLAVAT GRV
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