ID A5V115_ROSS1 Unreviewed; 576 AA.
AC A5V115;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Radical SAM domain protein {ECO:0000313|EMBL:ABQ92568.1};
GN OrderedLocusNames=RoseRS_4225 {ECO:0000313|EMBL:ABQ92568.1};
OS Roseiflexus sp. (strain RS-1).
OC Bacteria; Chloroflexota; Chloroflexia; Chloroflexales; Roseiflexineae;
OC Roseiflexaceae; Roseiflexus.
OX NCBI_TaxID=357808 {ECO:0000313|EMBL:ABQ92568.1, ECO:0000313|Proteomes:UP000006554};
RN [1] {ECO:0000313|Proteomes:UP000006554}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS-1 {ECO:0000313|Proteomes:UP000006554};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Bryant D.A., Richardson P.;
RT "Complete sequence of Roseiflexus sp. RS-1.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP000686; ABQ92568.1; -; Genomic_DNA.
DR RefSeq; WP_011958905.1; NC_009523.1.
DR AlphaFoldDB; A5V115; -.
DR STRING; 357808.RoseRS_4225; -.
DR KEGG; rrs:RoseRS_4225; -.
DR eggNOG; COG1032; Bacteria.
DR HOGENOM; CLU_021572_4_2_0; -.
DR OrthoDB; 9801424at2; -.
DR Proteomes; UP000006554; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF16; RADICAL SAM DOMAIN PROTEIN; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485}.
FT DOMAIN 68..202
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 295..515
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 576 AA; 65382 MW; B5AECFB74B9F7F98 CRC64;
MTDHETNATN GKHLAPGDKK QGIKLVAPAR ADERAGEIKF VEMPREKQPR LDVLVLNPPS
PDGDLFLRDI ARVGRRTRDG IIWPQTALAQ IGAVVKEAGY SVDVVDAIGL GMTWEEFERY
MYRHKPRYMV IHATAPTLTN DMRTTFLGKS VGTITMAIGT HVTPMSRETL ESYPTLDIVV
RGEPEMTILD VIQTIDRQVE LEKATDTVPV GNPDLTAPWR KLPFPDASYL TTRGRFLGVY
PQVIARALRE TRGVAFRNEH GEVQINPDRP FIENLDSLPL PLHHMLPWKK YKVPIVGGPY
TFVLTSRGCP AGCRYCIKHV TYQASVRHRS PQHVLEEMYM LKEMGMHHIH FEADLFTVKK
EFVYDLCNAI IKDGIKLQWS CNSRVDFVDE EELALMKKAG CFMIAWGLES GSEAVLKRAR
KGTTVKRIEE TIHASRKVGI KNWGYFIIGL PGETVETIQQ TIALSKRLPL DIALFHIATP
YPGTPFYYEA VENGWIQMDR WEDYDMYNHT VLNYPHLSSK DLEYWAKRAA REWSLRPGPI
MTFLKAASNR ETLGHLWKIG TNHIRWMSGS LTGSGA
//
