ID A5WWM0_DANRE Unreviewed; 437 AA.
AC A5WWM0; A0A8M1P1A0;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 128.
DE RecName: Full=vesicle-fusing ATPase {ECO:0000256|ARBA:ARBA00012674};
DE EC=3.6.4.6 {ECO:0000256|ARBA:ARBA00012674};
GN Name=vps4b {ECO:0000313|Ensembl:ENSDARP00000074209,
GN ECO:0000313|RefSeq:NP_001094432.1, ECO:0000313|RefSeq:NP_001278351.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040426-1235};
GN Synonyms=ch73-81e6.1 {ECO:0000313|RefSeq:NP_001094432.1,
GN ECO:0000313|RefSeq:NP_001278351.1}, zgc:63682
GN {ECO:0000313|RefSeq:NP_001094432.1,
GN ECO:0000313|RefSeq:NP_001278351.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000074209};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000111799}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000111799};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000074209, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000074209};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000074209}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000074209};
RG Ensembl;
RL Submitted (AUG-2013) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:NP_001094432.1, ECO:0000313|RefSeq:NP_001278351.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001094432.1,
RC ECO:0000313|RefSeq:NP_001278351.1};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [5] {ECO:0000313|RefSeq:NP_001094432.1, ECO:0000313|RefSeq:NP_001278351.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001094432.1,
RC ECO:0000313|RefSeq:NP_001278351.1};
RX PubMed=26161877;
RA Seiler C., Gebhart N., Zhang Y., Shinton S.A., Li Y.S., Ross N.L., Liu X.,
RA Li Q., Bilbee A.N., Varshney G.K., LaFave M.C., Burgess S.M.,
RA Balciuniene J., Balciunas D., Hardy R.R., Kappes D.J., Wiest D.L.,
RA Rhodes J.;
RT "Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T
RT lymphocyte Development in Zebrafish.";
RL PLoS ONE 10:e0131908-e0131908(2015).
RN [6] {ECO:0000313|RefSeq:NP_001094432.1, ECO:0000313|RefSeq:NP_001278351.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001094432.1,
RC ECO:0000313|RefSeq:NP_001278351.1};
RX PubMed=27247351;
RA Yang Q., Chen D., Xiong F., Chen D., Liu C., Liu Y., Yu Q., Xiong J.,
RA Liu J., Li K., Zhao L., Ye Y., Zhou H., Hu L., Tian Z., Shang X., Zhang L.,
RA Wei X., Zhou W., Li D., Zhang W., Xu X.;
RT "A splicing mutation in VPS4B causes dentin dysplasia I.";
RL J. Med. Genet. 53:624-633(2016).
RN [7] {ECO:0000313|RefSeq:NP_001094432.1, ECO:0000313|RefSeq:NP_001278351.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001094432.1,
RC ECO:0000313|RefSeq:NP_001278351.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004633}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004633}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|ARBA:ARBA00006914, ECO:0000256|RuleBase:RU003651}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX571948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU207344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001094432.1; NM_001100962.1.
DR RefSeq; NP_001278351.1; NM_001291422.1.
DR STRING; 7955.ENSDARP00000111799; -.
DR PaxDb; 7955-ENSDARP00000111799; -.
DR Ensembl; ENSDART00000079757.6; ENSDARP00000074209.5; ENSDARG00000069175.6.
DR Ensembl; ENSDART00000127693.4; ENSDARP00000111799.2; ENSDARG00000069175.6.
DR GeneID; 393880; -.
DR KEGG; dre:393880; -.
DR AGR; ZFIN:ZDB-GENE-040426-1235; -.
DR CTD; 9525; -.
DR ZFIN; ZDB-GENE-040426-1235; vps4b.
DR eggNOG; KOG0739; Eukaryota.
DR OrthoDB; 276256at2759; -.
DR TreeFam; TF105012; -.
DR Proteomes; UP000000437; Chromosome 2.
DR Bgee; ENSDARG00000069175; Expressed in zone of skin and 32 other cell types or tissues.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR GO; GO:0042476; P:odontogenesis; IMP:ZFIN.
DR GO; GO:0007033; P:vacuole organization; IBA:GO_Central.
DR CDD; cd02678; MIT_VPS4; 1.
DR CDD; cd19521; RecA-like_VPS4; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR007330; MIT_dom.
DR InterPro; IPR036181; MIT_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015415; Spast_Vps4_C.
DR InterPro; IPR045253; VPS4_MIT.
DR PANTHER; PTHR23074; AAA DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR23074:SF72; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4B; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF04212; MIT; 1.
DR Pfam; PF09336; Vps4_C; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00745; MIT; 1.
DR SUPFAM; SSF116846; MIT domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00674; AAA; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003651};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003651};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A5WWM0};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 3..81
FT /note="MIT"
FT /evidence="ECO:0000259|SMART:SM00745"
FT DOMAIN 159..295
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 76..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 4..36
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 437 AA; 48899 MW; 5F783C7CA70249D2 CRC64;
MAANNNLQKA IDLANKASQE DKAENYEEAL RLYQHAVQYF LHVVKYEAQG DKAKQSIRAK
CAEYLDRAEK LKEYLKKKEK APAKPVKESQ SNDKGNESDG EEDPEKKKFQ NQLSGAIVME
KPNIKWNDVA GLEGAKEALK EAVILPIKFP HLFTGKRTPW RGILLFGPPG TGKSYLAKAV
ATEANNSTFF SISSSDLVSK WLGESEKLVK SLFTLAREHK PSIIFIDEID SLCGSRSENE
SEAARRIKTE FLVQMQGVGN DNEGILVLGA TNIPWTLDSA IRRRFEKRIY IPLPEEHARS
FMFKLNLGTT PNSLTESDFM TLGKKTDGYS GADISIIVRD ALMQPVRKVQ SATHFKQVRG
PSRSDPNVIV DDLLTPCSPG DPQAKEMTWM EVPGEKLLEP IVSMSDMLRS LSNTKPTVNE
QDLEKLKKFT EDFGQEG
//
