ID   A5X6C3_9FUNG            Unreviewed;       133 AA.
AC   A5X6C3;
DT   10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   10-JUL-2007, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=Orotidine 5'-phosphate decarboxylase {ECO:0000256|ARBA:ARBA00021923, ECO:0000256|RuleBase:RU000512};
DE            EC=4.1.1.23 {ECO:0000256|ARBA:ARBA00012321, ECO:0000256|RuleBase:RU000512};
DE   Flags: Fragment;
GN   Name=pyrG {ECO:0000313|EMBL:ABG45841.1};
OS   Rhizopus sexualis.
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX   NCBI_TaxID=209164 {ECO:0000313|EMBL:ABG45841.1};
RN   [1] {ECO:0000313|EMBL:ABG45841.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NRRL 2567 {ECO:0000313|EMBL:ABG45841.1};
RA   Liu X.-Y., Zhneg R.-Y., Huang H.;
RT   "Molecular studies on Rhizopus (I): Relationships among species based on
RT   ITS rDNA and pyrG gene.";
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + orotidine 5'-phosphate = CO2 + UMP;
CC         Xref=Rhea:RHEA:11596, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:57538, ChEBI:CHEBI:57865; EC=4.1.1.23;
CC         Evidence={ECO:0000256|RuleBase:RU000512};
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC       UMP from orotate: step 2/2. {ECO:0000256|ARBA:ARBA00004861,
CC       ECO:0000256|RuleBase:RU000512}.
CC   -!- SIMILARITY: Belongs to the OMP decarboxylase family.
CC       {ECO:0000256|ARBA:ARBA00011018, ECO:0000256|RuleBase:RU000512}.
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DR   EMBL; DQ644951; ABG45841.1; -; Genomic_DNA.
DR   AlphaFoldDB; A5X6C3; -.
DR   UniPathway; UPA00070; UER00120.
DR   GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR014732; OMPdecase.
DR   InterPro; IPR018089; OMPdecase_AS.
DR   InterPro; IPR001754; OMPdeCOase_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   NCBIfam; TIGR01740; pyrF; 1.
DR   PANTHER; PTHR19278; OROTATE PHOSPHORIBOSYLTRANSFERASE; 1.
DR   PANTHER; PTHR19278:SF9; URIDINE 5'-MONOPHOSPHATE SYNTHASE; 1.
DR   Pfam; PF00215; OMPdecase; 1.
DR   SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
DR   PROSITE; PS00156; OMPDECASE; 1.
PE   3: Inferred from homology;
KW   Decarboxylase {ECO:0000256|ARBA:ARBA00022793,
KW   ECO:0000256|RuleBase:RU000512};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000512};
KW   Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975,
KW   ECO:0000256|RuleBase:RU000512}.
FT   DOMAIN          10..133
FT                   /note="Orotidine 5'-phosphate decarboxylase"
FT                   /evidence="ECO:0000259|Pfam:PF00215"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ABG45841.1"
FT   NON_TER         133
FT                   /evidence="ECO:0000313|EMBL:ABG45841.1"
SQ   SEQUENCE   133 AA;  14718 MW;  57EF4E0632ADA8CC CRC64;
     LLELMERKQT NLSVAVDVTT KKELISIADA IGPYICVLKT HIDIVEDFDA DLIQQLQELS
     KKHDFLFFED RKFADIGNTV KHQYANGVYK IASWSHITNA HTVPGEGIIK GLAEVGLPLG
     RGLLLLAEMS SKG
//