ID A5YPJ7_TRYCR Unreviewed; 206 AA.
AC A5YPJ7;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
DE Flags: Fragment;
OS Trypanosoma cruzi.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=5693 {ECO:0000313|EMBL:ABQ58181.1};
RN [1] {ECO:0000313|EMBL:ABQ58181.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Col1.7G2 {ECO:0000313|EMBL:ABQ58181.1};
RA Cerqueira G.C., Bartholomeu D.C., DaRocha W.D., Hou L., Freitas-Silva D.M.,
RA Machado C.R., El-Sayed N.M., Teixeira S.M.R.;
RT "Sequence diversity and evolution of multigene families in Trypanosoma
RT cruzi.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001593};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
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DR EMBL; EF578698; ABQ58181.1; -; Genomic_DNA.
DR AlphaFoldDB; A5YPJ7; -.
DR VEuPathDB; TriTrypDB:C4B63_44g150; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR028081; Leu-bd.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR Pfam; PF13458; Peripla_BP_6; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
PE 3: Inferred from homology;
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 46..183
FT /note="Leucine-binding protein"
FT /evidence="ECO:0000259|Pfam:PF13458"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABQ58181.1"
FT NON_TER 206
FT /evidence="ECO:0000313|EMBL:ABQ58181.1"
SQ SEQUENCE 206 AA; 22784 MW; FB214E8DBD754A13 CRC64;
VAQPSGGDRV VKVVSFEFGI TLLDAFSRNI MAGFNASLHS RNNSIMNGVR VEIVGKKTEF
TNYASDLSEA LKADNDIFAV VGHCGDKLLL NIKDVLAERD VVAFSPFTGS SLVRGWNPNF
YFLRAEPAAE LLALLRYALA HLRVRRLGFM YLQGVSFGDR EYAQAQRVMS ERNLTFSGVF
SVESSVTGVA RKEVFDAAWE AFAETR
//
