ID   A5YPT0_TRYCR            Unreviewed;       205 AA.
AC   A5YPT0;
DT   10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   10-JUL-2007, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE            EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
DE   Flags: Fragment;
OS   Trypanosoma cruzi.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=5693 {ECO:0000313|EMBL:ABQ58264.1};
RN   [1] {ECO:0000313|EMBL:ABQ58264.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=JG {ECO:0000313|EMBL:ABQ58264.1};
RA   Cerqueira G.C., Bartholomeu D.C., DaRocha W.D., Hou L., Freitas-Silva D.M.,
RA   Machado C.R., El-Sayed N.M., Teixeira S.M.R.;
RT   "Sequence diversity and evolution of multigene families in Trypanosoma
RT   cruzi.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001593};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC       {ECO:0000256|ARBA:ARBA00005381}.
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DR   EMBL; EF578781; ABQ58264.1; -; Genomic_DNA.
DR   AlphaFoldDB; A5YPT0; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   InterPro; IPR028081; Leu-bd.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR   Pfam; PF13458; Peripla_BP_6; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
PE   3: Inferred from homology;
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          33..187
FT                   /note="Leucine-binding protein"
FT                   /evidence="ECO:0000259|Pfam:PF13458"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ABQ58264.1"
FT   NON_TER         205
FT                   /evidence="ECO:0000313|EMBL:ABQ58264.1"
SQ   SEQUENCE   205 AA;  22716 MW;  C758518B150E5A1C CRC64;
     VAQPSGSDRV VKVVSFEFGI TLLDAFSRNI MAGFKASLHS RNNSIMNGVR VEIVEKKTEF
     TNYASDLSAA LADNDIFAVV GHCGDKLLLN IKDVLAERDV VAFSPFTGSS LVRGWNPNFY
     FLRAEPAAEL LALLRYALAH LRVRRLGFMY LQGVSFGDRE YAQAQRVMSE RNLTFSGVFS
     VESSVTDGAR KEVFDAAWEA FADTR
//