ID A5ZNM3_9FIRM Unreviewed; 700 AA.
AC A5ZNM3;
DT 24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE SubName: Full=Penicillin-binding protein, transpeptidase domain protein {ECO:0000313|EMBL:EDM88469.1};
GN ORFNames=RUMOBE_00590 {ECO:0000313|EMBL:EDM88469.1};
OS Blautia obeum ATCC 29174.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Blautia.
OX NCBI_TaxID=411459 {ECO:0000313|EMBL:EDM88469.1, ECO:0000313|Proteomes:UP000006002};
RN [1] {ECO:0000313|EMBL:EDM88469.1, ECO:0000313|Proteomes:UP000006002}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29174 {ECO:0000313|EMBL:EDM88469.1,
RC ECO:0000313|Proteomes:UP000006002};
RA Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA Thiruvilangam P., Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EDM88469.1, ECO:0000313|Proteomes:UP000006002}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29174 {ECO:0000313|EMBL:EDM88469.1,
RC ECO:0000313|Proteomes:UP000006002};
RA Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA Gordon J.;
RT "Draft genome sequence of Ruminococcus obeum (ATCC 29174).";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDM88469.1}.
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DR EMBL; AAVO02000002; EDM88469.1; -; Genomic_DNA.
DR RefSeq; WP_005426524.1; NZ_DS264338.1.
DR AlphaFoldDB; A5ZNM3; -.
DR GeneID; 79803524; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_5_2_9; -.
DR Proteomes; UP000006002; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR007887; MecA_N.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627:SF25; PENICILLIN-BINDING PROTEIN 3; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR Pfam; PF05223; MecA_N; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF54427; NTF2-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..153
FT /note="NTF2-like N-terminal transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF05223"
FT DOMAIN 160..341
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 376..679
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 700 AA; 77888 MW; E621C4ADB04184F9 CRC64;
MRKKKRKKHT KIITKIVLFS GILIGGGIGI VTIMNCNVPE KRLMEYMKYI EKGEYEQMYA
MLDQKKSSMN SKEEFIERNS KIYEGIEMSD LSITDITVKR QENGNAAVSY TTNMQTAAGN
VEFTNDAVFS HDWTGYHLIW QDQLIFPELS ATDKVQVTSE EAKRGDILDR NGRQLAGEGT
ASSVGIVPGR MENREDTIKK LAEYLGIGAD EIEDKLEAGW VKADSFVPVA TIPKIQEVDF
LTVNPDKTVL EEKEKQDTLL KIPGIMLSDV KVRTYYLKEA TSHLVGYVQA VTAEDLQEHK
GEGYRTNSVI GKTGLETLYE KELKGTDGCE ICIVDANGNK KSVIAYEPRK DGEDIHTTID
GDLQSTLYEQ FKEDRGCSVA LNPYTGEVLA LVSTPSYDNN DFVRGMDNSQ WSALNENEDR
PLYNRFRQTW CPGSTFKPVI AAIGLKVGAF TANDDFGNEG LAWQKDSSWG DYTVTTLHDY
EPVILKNALI YSDNIYFAKA ALKIGADQLM QSLNQIGFNQ ELPFDIKMSE SQYSNMDKIE
TEIQLADSGY GQGQILVNPL HLASIYTAFL NDGNMIKPYL HADGGSTSSE IWIKDAFSPQ
IVSEVMEGLE GVVNNPEGTG YGACREDIRL AGKTGTAELK ATKEDTSGTE IGWFTVFTTD
RDTKNPILLI SMVENVKDIG GSGYVVEKDK AILDEYLGNE
//
