ID A6BKU2_9FIRM Unreviewed; 336 AA.
AC A6BKU2;
DT 24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 1.
DT 24-JAN-2024, entry version 79.
DE SubName: Full=4-hydroxythreonine-4-phosphate dehydrogenase {ECO:0000313|EMBL:EDM61683.1};
DE EC=1.1.1.262 {ECO:0000313|EMBL:EDM61683.1};
GN Name=pdxA {ECO:0000313|EMBL:EDM61683.1};
GN ORFNames=DORLON_02949 {ECO:0000313|EMBL:EDM61683.1};
OS Dorea longicatena DSM 13814.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Dorea.
OX NCBI_TaxID=411462 {ECO:0000313|EMBL:EDM61683.1, ECO:0000313|Proteomes:UP000004016};
RN [1] {ECO:0000313|EMBL:EDM61683.1, ECO:0000313|Proteomes:UP000004016}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13814 {ECO:0000313|EMBL:EDM61683.1,
RC ECO:0000313|Proteomes:UP000004016};
RA Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA Thiruvilangam P., Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EDM61683.1, ECO:0000313|Proteomes:UP000004016}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13814 {ECO:0000313|EMBL:EDM61683.1,
RC ECO:0000313|Proteomes:UP000004016};
RA Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA Gordon J.;
RT "Draft genome sequence of Dorea longicatena (DSM 13814).";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000256|ARBA:ARBA00001968};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the PdxA family. PdxA2 subfamily.
CC {ECO:0000256|ARBA:ARBA00009464}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDM61683.1}.
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DR EMBL; AAXB02000028; EDM61683.1; -; Genomic_DNA.
DR RefSeq; WP_006428014.1; NZ_DS264411.1.
DR AlphaFoldDB; A6BKU2; -.
DR eggNOG; COG1995; Bacteria.
DR HOGENOM; CLU_040168_0_1_9; -.
DR Proteomes; UP000004016; Unassembled WGS sequence.
DR GO; GO:0050570; F:4-hydroxythreonine-4-phosphate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR005255; PdxA_fam.
DR NCBIfam; TIGR00557; pdxA; 1.
DR PANTHER; PTHR30004; 4-HYDROXYTHREONINE-4-PHOSPHATE DEHYDROGENASE; 1.
DR PANTHER; PTHR30004:SF6; D-THREONATE 4-PHOSPHATE DEHYDROGENASE; 1.
DR Pfam; PF04166; PdxA; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EDM61683.1}.
SQ SEQUENCE 336 AA; 36464 MW; 9B918C4A240D008E CRC64;
MKKPVIAIPI GDPAGVGPEI VAKSIASDEV FQIAVCVIVG DRKIVEKAIE ITGENLKINE
IKEPEEAVDE KGVLNLINLD NVDMDTFAYG KVSAMCGKAA YEYIAKSIEL ANAGKVDAVA
TTPINKESLH AAEVPYIGHT EIFGALTHTE DPLTMFETNG MRVFFLTRHV SLRQMLDMIK
KDRIIDYVKR CTKALERLGV KEGTMAIAGL NPHSGEHGLF GWEEVEEIMP AIEELKAEGY
DVAGPIGADS VFHQAAQGKY TSVLSLYHDQ GHIATKTLDF EKTIAITNGM PILRTSVDHG
TAFDIAGKGI VSAVSMIEAI RLAAKYAPNF TGKHEK
//
