ID A6EME8_9BACT Unreviewed; 900 AA.
AC A6EME8;
DT 24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 1.
DT 13-SEP-2023, entry version 82.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SCB49_08062 {ECO:0000313|EMBL:EDM45748.1};
OS unidentified eubacterium SCB49.
OC Bacteria; Bacteroidota; environmental samples.
OX NCBI_TaxID=50743 {ECO:0000313|EMBL:EDM45748.1, ECO:0000313|Proteomes:UP000003659};
RN [1] {ECO:0000313|EMBL:EDM45748.1, ECO:0000313|Proteomes:UP000003659}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCB49 {ECO:0000313|EMBL:EDM45748.1,
RC ECO:0000313|Proteomes:UP000003659};
RA Hagstrom A., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G.,
RA Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDM45748.1}.
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DR EMBL; ABCO01000001; EDM45748.1; -; Genomic_DNA.
DR AlphaFoldDB; A6EME8; -.
DR STRING; 50743.SCB49_08062; -.
DR Proteomes; UP000003659; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000003659}.
FT DOMAIN 718..734
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 644..651
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 900 AA; 101109 MW; 9D09E93875C9285B CRC64;
MENSVTGKLK SAVVTQNHTM SKPKKVTPLM KQYNAIKAKY PDALLLFRVG DFYETFGADA
VKAAGILNIT LTARNNGGEQ TELAGFPHHS LNTYLPKLVM AGCRVAICDQ LEDPKMTKTI
VKRGVTELVT PGVALNDDIL QSKSNNFLAA VHFGPSTGSG TQKNQRIGVA FLDISTGEFL
TSEGNAEYID KLLQNFNPSE VLFSKQKRKL FSETFGDNFH VFHLEDWVFQ KDYTDETLNK
QFNTKNLKGF GIDHLEQGII ASGAALHYLS ETQHNKLEHI TRIARIAEDE FVWMDRFTIR
NLELYHSSNQ NAVTLLDVID KTISPMGGRM LKRWMALPLK NVETITRRHE VVSYLLQENQ
VLDKIKTNIK RIGDLERLIS KVATGKISPR EVIQLKNSLE AVVPVKKISE TSENESLKIL
GSQLQECEVL RNKIKATIHE EAPVNIVKGN AIASGFHPEL DELRAIATGG KEYLDKMLAR
ETERTGITSL KIASNNVFGY YIEVRNTHKD KVPTEWVRKQ TLVNAERYIT EELKEYEAKI
LGAEEKIGAL EQEIFVKLIQ WMIQFIGPVQ QNAKLIAELD CLGSFATQAA DANYVRPLFD
ETTDLDIKEG RHPVIEKQLP PDAPFISNDV FLDREHQQII MITGPNMSGK SAILRQTALI
VLLAQMGSFV PAGALRMGVV DKIFTRVGAS DNISMGESTF MVEMNETASI LNNISERSLV
LLDEIGRGTS TYDGISIAWA ISEYLHEHPS HAKVLFATHY HEINEMTETF SRIKNYNVSV
KELEDDVLFL RKLVPGGSQH SFGIHVAKMA GMPQAVLNRA NKILKRLEKS HSSEELSDKM
KQISEEELQL SFFNLDDPLL EELRDEISGI DIDTLTPVEA LMKLNEMKRM LQRSAKVKKA
//
