ID   A6EPA5_9BACT            Unreviewed;      1109 AA.
AC   A6EPA5;
DT   24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2007, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=SCB49_14020 {ECO:0000313|EMBL:EDM44694.1};
OS   unidentified eubacterium SCB49.
OC   Bacteria; Bacteroidota; environmental samples.
OX   NCBI_TaxID=50743 {ECO:0000313|EMBL:EDM44694.1, ECO:0000313|Proteomes:UP000003659};
RN   [1] {ECO:0000313|EMBL:EDM44694.1, ECO:0000313|Proteomes:UP000003659}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCB49 {ECO:0000313|EMBL:EDM44694.1,
RC   ECO:0000313|Proteomes:UP000003659};
RA   Hagstrom A., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G.,
RA   Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EDM44694.1}.
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DR   EMBL; ABCO01000003; EDM44694.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6EPA5; -.
DR   STRING; 50743.SCB49_14020; -.
DR   Proteomes; UP000003659; Unassembled WGS sequence.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR046816; MmeI_Mtase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR025931; TaqI_C.
DR   PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR   PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR   Pfam; PF20473; MmeI_Mtase; 1.
DR   Pfam; PF12950; TaqI_C; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:EDM44694.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003659};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          455..660
FT                   /note="MmeI-like DNA-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF20473"
FT   DOMAIN          800..965
FT                   /note="TaqI-like C-terminal specificity"
FT                   /evidence="ECO:0000259|Pfam:PF12950"
SQ   SEQUENCE   1109 AA;  127424 MW;  0C6297B06FB7639E CRC64;
     MALYQVSVLK QHITLQDKEL VDKAYKKYTK YFLNPTIQDN IRSSKEEEYQ GIFLTELFVK
     ILGYTLKPNA DFNLVAEYKN QTNARKADGA ILHKDVAIGV IELKGTNTKD LESIRKQAFD
     YKANQKGCVY VITSNFEKLR FYINDATEFE EFNLFELSPE RFELLYLCLQ KDNIINNVPL
     KIKEASVVEE EQITKQFYKD YSVFKRELYR DLVKRNAKSL KAQASSDTSS AVERSQEEQL
     ELQRLEKNVK LTLFKKSQKL IDRYLFIFFA EDRGLLPANS TQQILDKWKD DVDFGDDRPL
     YTLFKQYFNF LDQGRAGTAK RAEIYAYNGG LFKEDKTLDS LDIDSDLLYK HTSKLAAYDF
     ESQVDVNILG HIFENSLNEI ESVNAEIEGG DFDKQKSKRK KDGVFYTPKY ITKYIVENTI
     GKLCDEKKTE LGFKEEEYFK GRKNRQKATI TKLVNILDTY RDWLLQLTIC DPACGSGAFL
     NQALDFLIKE HSYIDELKTK VLGGGLQFSD IENTILENNI YGVDLNEESV EIAKLSLWLR
     TAQPRRKLNN LNSNIKCGNS LIDSKTVAGD KAFNWEEQFP KVFDPSSGSG GGFDVVIGNP
     PYVRVQNLDS NLVDYYFENY KSPKGKLDLS ILFFEKVFSL IKTEGKASFI SSSQWMQTDY
     GENIRNILSE KKILEIINFG SLPVFENVET YPAIFFLTNN GFTQFKYREV PNKESLSYSG
     ISNSPTKGYS FDKISSEPWQ FSAFNLIEYL NDNNIYFQEL KKYAPAFIGC LTGMDAAFVV
     NAEIIKEYNL ENEIIIPYAY RGQEISRYST TFPAASIIYP YHNENGSSEL FEDDYFSENF
     PNCYNYLSGF KEELKSRKDS RKNYAFENNF FRHLRAGSFN YIMPKKLVLK GVDTKFTVGL
     LDNNTSFNGA NTPALIPETN SDISIAGLIS ILNSTLITFY LNQICPKKLG GYYRYNAKNV
     SAIPIIKPSN NELSELGQNI TNLSTEFNLF ISKTTSYLIS KYNLSKISRK LENWQELEFG
     DFIKELNKSI KANNKLRAKQ VAEGVISSAV EIPTLTKKDE FEWLDLFEEN KQKAQALQTQ
     INQTDAEIDA MVYELYGLTE EEIAIVENS
//