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Database: UniProt
Entry: A6KWC5_BACV8
LinkDB: A6KWC5_BACV8
Original site: A6KWC5_BACV8 
ID   A6KWC5_BACV8            Unreviewed;       471 AA.
AC   A6KWC5;
DT   24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2007, sequence version 1.
DT   27-SEP-2017, entry version 82.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=BVU_0001 {ECO:0000313|EMBL:ABR37731.1};
OS   Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC
OS   14291 / NCTC 11154).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=435590 {ECO:0000313|EMBL:ABR37731.1, ECO:0000313|Proteomes:UP000002861};
RN   [1] {ECO:0000313|EMBL:ABR37731.1, ECO:0000313|Proteomes:UP000002861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154
RC   {ECO:0000313|Proteomes:UP000002861};
RX   PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA   Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M.,
RA   Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P.,
RA   Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A.,
RA   Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I.;
RT   "Evolution of symbiotic bacteria in the distal human intestine.";
RL   PLoS Biol. 5:1574-1586(2007).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP000139; ABR37731.1; -; Genomic_DNA.
DR   ProteinModelPortal; A6KWC5; -.
DR   STRING; 435590.BVU_0001; -.
DR   EnsemblBacteria; ABR37731; ABR37731; BVU_0001.
DR   KEGG; bvu:BVU_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; VENWVKD; -.
DR   Proteomes; UP000002861; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002861};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002861}.
FT   DOMAIN      166    296       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      378    447       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     174    181       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   471 AA;  53972 MW;  5F7E83CB44F2CE9D CRC64;
     MFHMIENDHV VLWGRCLNLI RDNVPETTFK TWFEPIVPLK YEDKALTIGV PSPFFYEFLE
     EKFVDLLRAA LYKEIGEGTQ LMYCILTDKT NHITVNMEGS KRSSALPTQT VIRDGNKAPN
     PMQAPAPQDL DPHLNPNYNF ENFIKGNSNE FSRTVGETVA KNPAKTFNPL FLYGPSGVGK
     THLTNAIGTR IKELYPEKRV LYVSAHLFQV QYTDSVRTNH FNDFISFYQT IDVLIIDDIQ
     EFAGVTKTQN TFFHIFNHLH QNGKQLILTS DRAPVMLQGM EERLLTRFKW GLVAELEKPD
     VELRKNILRN KIRRDGLNIP ETVINYIAEN VNESVRELEG IINSLLAQSI IFKRDVDLDL
     AERIVRKAVR CCESKPVTVE DIIQKVCSHY EIEESAIHTK TRKREVVQVR QVAMYLAKKH
     TDSSSSKIGK LIGNKDHATV LHACKIVKDQ VEVDKAFKAD IEEIEASLKR K
//
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