ID   A6MIZ4_PHYPA            Unreviewed;       574 AA.
AC   A6MIZ4;
DT   24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2007, sequence version 1.
DT   22-FEB-2023, entry version 43.
DE   RecName: Full=Trehalase {ECO:0000256|RuleBase:RU361180};
DE            EC=3.2.1.28 {ECO:0000256|RuleBase:RU361180};
DE   AltName: Full=Alpha-trehalose glucohydrolase {ECO:0000256|RuleBase:RU361180};
OS   Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC   Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrium.
OX   NCBI_TaxID=3218 {ECO:0000313|EMBL:ABO61746.1};
RN   [1] {ECO:0000313|EMBL:ABO61746.1}
RP   NUCLEOTIDE SEQUENCE.
RX   AGRICOLA=IND43941855;
RA   Lunn J.E.;
RT   "Gene families and evolution of trehalose metabolism in plants.";
RL   Funct. Plant Biol. 34:550-563(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-
CC         glucose; Xref=Rhea:RHEA:32675, ChEBI:CHEBI:15377, ChEBI:CHEBI:15903,
CC         ChEBI:CHEBI:16551, ChEBI:CHEBI:17925; EC=3.2.1.28;
CC         Evidence={ECO:0000256|ARBA:ARBA00001576,
CC         ECO:0000256|RuleBase:RU361180};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 37 family.
CC       {ECO:0000256|ARBA:ARBA00005615, ECO:0000256|RuleBase:RU361180}.
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DR   EMBL; EF151135; ABO61746.1; -; mRNA.
DR   AlphaFoldDB; A6MIZ4; -.
DR   CAZy; GH37; Glycoside Hydrolase Family 37.
DR   HOGENOM; CLU_006451_4_2_1; -.
DR   BRENDA; 3.2.1.28; 4802.
DR   GO; GO:0004555; F:alpha,alpha-trehalase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005991; P:trehalose metabolic process; IEA:InterPro.
DR   Gene3D; 1.50.10.10; -; 1.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR001661; Glyco_hydro_37.
DR   InterPro; IPR018232; Glyco_hydro_37_CS.
DR   PANTHER; PTHR23403; TREHALASE; 1.
DR   PANTHER; PTHR23403:SF1; TREHALASE; 1.
DR   Pfam; PF01204; Trehalase; 1.
DR   PRINTS; PR00744; GLHYDRLASE37.
DR   SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
DR   PROSITE; PS00928; TREHALASE_2; 1.
PE   2: Evidence at transcript level;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361180};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361180};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           36..574
FT                   /note="Trehalase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002696962"
SQ   SEQUENCE   574 AA;  65004 MW;  57EAE207C4574ECB CRC64;
     MVLEGFMAAC GQTVVSTGVS KLLTLLVAIQ SAALASFGGG PDFDPKYYVD IPLRYSLNET
     ARAFDALPRL QNNTIPPRVL EQFLSQYFEL ADSNVIADAP KDFNRIPQNF LPLVHNPQVR
     KWALQIHELW LELSRKISPS VAMNPNKNTL LPLNNTVLVP GARFREVYYW DSYWVIKGLL
     VSGMTDTAKG VIENLMELAE RYGFVPNGAR IYYENRSQTP LLSMMIRAVY EKTHDKALLK
     RALPILLREH AFWTSEPHEV RVRDKNGDEH RLSRFWAHWN SPRPESFTID THVARGMNKS
     RAAQLYHDIA TAAESGWDFS SRWMEDQQNL RTLRTSMIIP VDLNAFLFQM EKNVEYFASI
     LGNQTIQTQF ASAASDRQRA IQRILWSRKR GQWFDAWLSP NGCSFSENDN KTIVYEWKQK
     RLTYASNFVP LWAGVLPKGD PRRALVVEAL NKSGLVLPAG IATSLRNTGQ QWDFPNAWAP
     LVDMVIEGLD ASGIPRGKMM AKAISQSWIR SNYEAYHQVG KMLEKYDATS CGKIGGGGEY
     NLQTGFGWSN GVVLSLLQKY GWPADKPLFC PDAL
//