ID A6MW42_PANPA Unreviewed; 2044 AA.
AC A6MW42;
DT 24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=PKDREJ {ECO:0000313|EMBL:ABR22605.1};
DE Flags: Fragment;
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|EMBL:ABR22605.1};
RN [1] {ECO:0000313|EMBL:ABR22605.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17564962; DOI=10.1086/518695;
RA Hamm D., Mautz B.S., Wolfner M.F., Aquadro C.F., Swanson W.J.;
RT "Evidence of amino acid diversity-enhancing selection within humans and
RT among primates at the candidate sperm-receptor gene PKDREJ.";
RL Am. J. Hum. Genet. 81:44-52(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; EF517280; ABR22605.1; -; Genomic_DNA.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR PANTHER; PTHR10877:SF150; POLYCYSTIC KIDNEY DISEASE AND RECEPTOR FOR EGG JELLY-RELATED PROTEIN; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 974..995
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1179..1197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1217..1237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1363..1389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1401..1423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1498..1522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1756..1776
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1788..1808
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1828..1854
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1875..1902
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1937..1963
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..702
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 1019..1136
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 1284..1351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1320..1334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1335..1351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1597..1614
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABR22605.1"
FT NON_TER 2044
FT /evidence="ECO:0000313|EMBL:ABR22605.1"
SQ SEQUENCE 2044 AA; 233743 MW; 31C444F4AC85570F CRC64;
INACVIQRVR INTDQKGAPV RLSMKAEATI NASVQLDCPA ARAIAQYWQV FSVPAVGQAP
DWTQPLDLPQ LEIRNSPLFI HIPSNSLQWG VYVFNFTVSI TTGNPKMPEV KDSDAVYVWI
XRSSLQAVVL GDANITANFT EQLILDGSTS SDPDADSPLQ GLQFFWYCTT DPRNYRGDRI
NLGSKEVCXP EQANLKWPWA SGPVLTLLPE TLKGDHVYFF RMVIRKDSRT AFSDKRVHVL
QGPKAIAHIT CIENCERNFI VSDRFSLFLN CTNCASRDFY KWSILSSSGG EMLFDWMGET
VTGRNGAYLS IKAFAFRHFL EAEFSISLYL ACWSGVTSVF RHSFIINHGP QIGECKINPA
KGIALITKFV VQCSNFRDKH VPLTYKIIVS DLHSVGEISS VKENTLGTIL YLGPQSTAPP
SFLPVGTLAS QYGLKIYAQV YDSLGAFSQV TLHATAQAPT DKNSSKTVLN QLLSFTVGPS
SLLSTLIQKQ DFLPAGYLLY IVASVLNNMK TELPLQDDRV NLRKHLIDQS FLLPVSTLVE
IGQVVMTITK LTQKPSEFTW DAQKRATMRV WQANQALQEY QQKDKRFRSE QIEIVSTGIL
MSLSNILKMT SPHQVVKDPF YVIESLSDTI LANKVPGNKT TSMRTPNFNM YVKKVEKWGI
NQLFRNEKHC RNCFYPTLNV SSVPGLSANG PVSTMFCDFT NDPFPWLNDQ ENTSVEVSGF
RMTGVADNGS VLEITPDVAE VYLVRKNLTF AAFNLTVGPN SEVDGSLKKT TGGFSFQVDS
TVLREVLVHI VTEVMVLFTV LVYTGSQITP TALVATFLVP HDIPPVASQS ALFDPACXVK
KARVVCLPVS LLQLIAQHSH SPHCTVSXVL QAPRFVMKXN DKLVRISIFS XQCLDMYGIQ
SEWREGYCXL GEKTSWHXVH CICKXXVRAR RQLGXXGLTX IHLHTHYVMA KVIVIPNPVD
LRLNIIKSLH QNPVTXFTVL FIILLYVGLA FWALYRDEMD QHLRGHVIVL PDNDPYDNLC
YLVTIFTGSR WGSGTRANVF VQLRGTVSTS DVHCLSHPHF TTLYRGSINT FLLTTKSDLG
DIHSIRVWHN NEGRSPSWYL SRIKVENLFS RHIWLFICQK WLSVDTTLDR TFHVTHPDEP
LTRKDFFFID VSSNLRKNHM WFSIFASVVA KTFNRLQRLS CCLAMLLSSL LCNIMFFNLN
RQEQTESRER KYMRSMMIGI ESVLITIPVQ LLITFLFTCS QRKPQADLNE VSPQKHPLMS
EASEHWEEYL RKWHAYETAK VHPREVAKPA SKGKPRLPKA SPKATSKPKH RHRKAQIKTP
ETLGPNTNSX NNIEDDQDVH SEXXQHPSQK DLQQLKKKPR IVLPWWCVYV AWFLVFATSS
ISSFFIVFYG LTYGYDKSIE WLFASFCSFC QSVLLVQPSK IILLSGFRTN KPKYCKNLSW
STEYKYTEIR LDGMRMHPEE MQRIHDQIVR IRGTRMYQPL TEDEIRIFKR KKRIKRRALL
FLSYILTHFI FLALLLILIV LLRHTDCFYY NQFIRDRFSM DLATVTKLED IYRWLNSVLL
PLLHNDLNPT FLPESSSKIL GLPLMRQVRA KSSEKMCLPA EKFVQNSIRR EIHCHPKYGI
DPEDTKNYSG FWNEVDKQAI DESTNGFTYK PQGTQWLYYS YGLLHTYGSG GYALYFFPEQ
QRFNSTRRLK ELQESNWLDE KTWAVVLELT TFNPDINLFC SISVIFEVSQ LGVVNTSVSL
HSFSLADFDR KASAEIYLYV AILIFFLAYV VDEGCIIMQE RASYVRSVYN LLNFALKCIF
TVLIVLFLRK HFLATGIIRF YLSNPEDFIP FHAVSQVDHI MRIILGFLLF LTILKTLRYS
RFFYDVRLAQ RAIQAALPGI CHMAFVVSVY FFVYIAFGYL VFGQHEWNYS NLIHSTQTVF
SYCVSAFQNT EFSNNRILGV LFLSSFMLVM ICVLINLFQA VILSAHEGMK QPVYEEPSDE
VEAMTYLCRK LRTMFSFLTS QSKAKDEPEF FIDMLYGQPE KNSHRYLGLK TRNINGKKMV
YLVV
//
