ID A6MW43_9PRIM Unreviewed; 2043 AA.
AC A6MW43;
DT 24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=PKDREJ {ECO:0000313|EMBL:ABR22606.1};
DE Flags: Fragment;
OS Gorilla gorilla (western gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9593 {ECO:0000313|EMBL:ABR22606.1};
RN [1] {ECO:0000313|EMBL:ABR22606.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17564962; DOI=10.1086/518695;
RA Hamm D., Mautz B.S., Wolfner M.F., Aquadro C.F., Swanson W.J.;
RT "Evidence of amino acid diversity-enhancing selection within humans and
RT among primates at the candidate sperm-receptor gene PKDREJ.";
RL Am. J. Hum. Genet. 81:44-52(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; EF517281; ABR22606.1; -; Genomic_DNA.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR PANTHER; PTHR10877:SF150; POLYCYSTIC KIDNEY DISEASE AND RECEPTOR FOR EGG JELLY-RELATED PROTEIN; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 973..994
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1178..1196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1216..1238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1362..1388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1400..1422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1497..1521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1755..1775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1787..1807
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1827..1853
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1874..1901
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1936..1962
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3..701
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 1018..1135
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 1280..1350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1319..1333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1334..1350
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1596..1613
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABR22606.1"
FT NON_TER 2043
FT /evidence="ECO:0000313|EMBL:ABR22606.1"
SQ SEQUENCE 2043 AA; 233879 MW; AB7352E3E3E80473 CRC64;
NACVIQRVRI NTDQKGAPVR LSMKAEATIN ASVQLDCPAA RAIAQYWQVF SVPAVGQAPD
WTQPLDLPQL EIRNSPLFIH IPSNSLQWGV YVFNFTVSIT TGNPKMPEVX DSDAVYVWIV
RSSLQAVMLG DANITANFTE QLILDGSTSS DPDADSPLQG LQFFWYCTTD PRNYRGDRII
LGSKEVCHPE QANLKWPWAS GPVLTLLPET LKGDHVYFFR MVIRKDSRTA FSDKRVHVLQ
GPKAXAHITC IENCERNFIV SDRFSLFLNC TNCASRDFYK WSILSSSGGE MLFDWMGETV
TGRNGAYLSI KAFAFRHFLE AEFSISLYLA CWSGVTSVFR HSFIINHGPQ IGECKINPAK
GIALITKFVV QCSNFRDKHV PLTYKIIVSD LHSVGEISSV KENTLGTILY LGPQSTVPPS
FLPVGTLASQ YGLKIYAQVY DSLGAFSQVT LHATAQAPTD KNSSKTVLNQ LLSFTVGPSS
LLSTLIQKQD FLPAGYLLYI VASVLNNMKT ELPLQDDRVN LRKHLIDQSF LLPVSTLVEI
GQVVMTITKL TQKPSEFTWD AQKRATMRVW QANQALQEYQ QKDKHFRSEQ IEIVSTGILM
SLSNILKMTS PHQVVKDPFY VIESLSDTIL ANKVPGNKTT SMRTPNFNMY VKKVEKWGIN
QLFRNEKHCR NCFYPTLNVS SVPGLSANGP ISTMFCDFTN DTFPWLNDQE NTSVEVSGFR
MTGVADNGSV LEITPDVAEV YLVRKNLTFA AFNLTVGPXR EVDGSLKKTT GGFSFQVDST
VLREVLVHIV TEVMVLFTVL VYTGSQITPT ALVATFLVPH DIPPVASQSA LFDPACTVKK
ARVVCLPVSL LQLIAQHSHS PHCTVSIVLQ APRFVMKLND KLVRISIFSV QCLDMYGIQS
EWREGYCILG EKTSWHEVHC ICKKVVRARR QLGTIGLTGI HLHTHYVMAK VIVIPNPVDL
RLNIIKSLHQ NPVTLFTVLF IILLYVGLAF WALYRDEMDQ HLRGHVIVLP DNDPYDNLCY
LVTIFTGSRW GSGTRANVFV QLRGTVSASD VHCLSHPHFT TLYRGSINTF LLTTKSDLGD
IHSIRVWHNN EGRSPSWYLS RIKVENLFSR HIWLFICQKW LSVDTTLDRT FHVTHPDEPL
TRKAFFFIDV SSNLQKNHMW FSIFASVVAK TFNRLQRLSC CLAMLLSSLL CNIMFFNLNR
QEETESRERK YMRSMMIGIE SVLITIPVQL LITFLFTCSQ RKPQADLKEV SPQKHPLMSE
ASEHWEEYLR KWHAYETAKV HPREXAKPAS KGKPRLPKAS PKATSKPKHR HRKAQIKTPE
TLGPNTNSNN NIEDDQDVHS EXXQHPSQKD LQQLKKKPRI VLPWWCVYVA WFLVFATSSI
SSFFIVFYGL TYGYDKSIEW LFASFCSFCQ SVLLVQPSKI ILLSGFRTNK PKYCKNLSWS
TKYKYTEIRL DEMRMHPEEM QRIHDQIVRI RGTRMYQPLT EDEIRIFKRK KRIKRRALLF
LSYFLTHFIF LVLLLILIVL LRHTDCFYYN QFIRDRFSMD LATVTKLEDI YRWLNSVLLP
LLHNDLNPTF LPESSSKILG LPLMRQVRAK SSDKMCLPAE KFVQNSIRRE IHCHPKYGID
PEDTKNYSGF WNEFDKQAID ESTNGFTYKP QGKQWLYYSY GLLHTYGSGG YALYFFPEQQ
RFNSTLRLKE LQESNWLDEK TWAVVLELTT FNPDINLFCS ISVIFEVSQL GVVNTSISLH
SFSLADFDRK ASAEIYLYVA ILIFFLAYXV DEGCIIMQER ASYVRSVYNL LNFALKCIFT
VLIVLFLRKH FLATGIIRFY LSNPEDFIPF HAVSQVDHIM RIILGFLLFL TILKTLRYSR
FFYDVRLAQR AIQAALPGIC HVAFVVSVYF FVYMAFGYLV FGQHEWNYSN LIHSTQTVFS
YCVSAFQNTE FSNNRILGVL FLSSFMLVMI CVLINLFQAV ILSAYEEMKQ PVYEEPSDEV
EAMTYLCRKL RTMFSFLTLQ SKAKDEPEFF IDMLYGQPEK NSHRYLGLKT RNINGKKTVY
LVV
//
