ID A6MY55_9HIV1 Unreviewed; 336 AA.
AC A6MY55;
DT 24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:ABR19349.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:ABR19349.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ABR19349.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ABR19349.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=4011 {ECO:0000313|EMBL:ABR19349.1};
RX PubMed=17955437; DOI=10.1086/521678;
RG EuroSIDA Study Group;
RA Ceccherini-Silberstein F., Cozzi-Lepri A., Ruiz L., Mocroft A.,
RA Phillips A.N., Olsen C.H., Gatell J.M., Gunthard H.F., Reiss P.,
RA Perno C.F., Clotet B., Lundgren J.D.;
RT "Impact of HIV-1 reverse transcriptase polymorphism F214L on virological
RT response to thymidine analogue-based regimens in antiretroviral therapy
RT (ART)-naive and ART-experienced patients.";
RL J. Infect. Dis. 196:1180-1190(2007).
CC -!- SIMILARITY: Belongs to the retroviral Pol polyprotein family.
CC {ECO:0000256|RuleBase:RU004064}.
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DR EMBL; EF563584; ABR19349.1; -; Genomic_DNA.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR CDD; cd05482; HIV_retropepsin_like; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001995; Peptidase_A2_cat.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR034170; Retropepsin-like_cat_dom.
DR InterPro; IPR018061; Retropepsins.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00077; RVP; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50175; ASP_PROT_RETROV; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750,
KW ECO:0000256|RuleBase:RU004064};
KW DNA integration {ECO:0000256|ARBA:ARBA00023195};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU004064};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|RuleBase:RU004064};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW Virion maturation {ECO:0000256|ARBA:ARBA00023113};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023195};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 17..86
FT /note="Peptidase A2"
FT /evidence="ECO:0000259|PROSITE:PS50175"
FT DOMAIN 140..330
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABR19349.1"
FT NON_TER 336
FT /evidence="ECO:0000313|EMBL:ABR19349.1"
SQ SEQUENCE 336 AA; 38300 MW; 6D7AF087F3709D80 CRC64;
TLWQRPLVSI KVGGQIKEAL LDTGADDTVL EEINLPGKWK PKMIGGIGGF IKVRQYDQIT
LEICGKRAIG TVLVGPTPVN IIGRNMLTQL GCTLNFXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXCXEMEKE GKITKIGPEN PYNTPVFAIK KKDSTKWRKL VDFRELNKRT
QDFWEVQLGI PHPAGLKKKK SVTVLDVGDA YFSVPLDESF RKYTAFTIPS INNETPGIRY
QYNVLPQGWK GSPSIFQSSM TKILEPFRTQ NPEIVIYQYM DDLYVGSDLE IGQHRAKIEE
LREHLLKWGF TTPDKKHQKE PPFLWMGYEL XPDKWT
//