ID A6N2F6_9BACI Unreviewed; 349 AA.
AC A6N2F6;
DT 24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Cd(2+)-exporting ATPase {ECO:0000256|ARBA:ARBA00039103};
DE EC=7.2.2.21 {ECO:0000256|ARBA:ARBA00039103};
DE Flags: Fragment;
GN Name=cadA {ECO:0000313|EMBL:ABR09921.1};
OS Bacillus sp. N10.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=447063 {ECO:0000313|EMBL:ABR09921.1};
RN [1] {ECO:0000313|EMBL:ABR09921.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=N10 {ECO:0000313|EMBL:ABR09921.1};
RX PubMed=18176824; DOI=10.1007/s00284-007-9064-x;
RA Zhang Y., Zhang H., Li X., Su Z., Zhang C.;
RT "The cadA gene in cadmium-resistant bacteria from cadmium-polluted soil in
RT the Zhangshi area of Northeast China.";
RL Curr. Microbiol. 56:236-239(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + Cd(2+)(in) + H2O = ADP + Cd(2+)(out) + H(+) + phosphate;
CC Xref=Rhea:RHEA:12132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:48775,
CC ChEBI:CHEBI:456216; EC=7.2.2.21;
CC Evidence={ECO:0000256|ARBA:ARBA00036510};
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|ARBA:ARBA00006024}.
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DR EMBL; EF590250; ABR09921.1; -; Genomic_DNA.
DR AlphaFoldDB; A6N2F6; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd00371; HMA; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR PANTHER; PTHR48085; CADMIUM/ZINC-TRANSPORTING ATPASE HMA2-RELATED; 1.
DR PANTHER; PTHR48085:SF5; CADMIUM_ZINC-TRANSPORTING ATPASE HMA2; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR PRINTS; PR00941; CDATPASE.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW Cadmium {ECO:0000256|ARBA:ARBA00022539};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 80..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..51
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABR09921.1"
FT NON_TER 349
FT /evidence="ECO:0000313|EMBL:ABR09921.1"
SQ SEQUENCE 349 AA; 38095 MW; 993D675ACA5DEC80 CRC64;
NCAGKFENNV KQLAGVEDAK VNFGASKIAV YGNATIEELE KAGAFENLKV TPEKSARQAS
QEVKEDTKED KVPFYKKHST LLYASLLIAF GYLSSYVNGE ENIVTTLLFL ASMFIGGLSL
FKVGLQNLLR FEFDMKTLMT VAVIGGAIIG EWAEVAIVVI LFAISEALER FSMDRARQSI
RSLMDIAPKE ALVRRNGQEI MIHVDDITVG DIMIVKPGQK IAMDGVVVSG YSAVNQAAIT
GESVPVEKTI DDEVFAGTLN EEGLLEVKIT KLVEDTTISK IIHLVEEAQG ERAPSQAFVD
KFAKYYTPII MIIAALVAIV PPLFFDASWE TWVYQGLAVL VVGCPCALV
//
