ID ME3L1_HUMAN Reviewed; 274 AA.
AC A6NDR6;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Putative homeobox protein Meis3-like 1;
GN Name=MEIS3P1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/MEIS homeobox family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AC015922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A6NDR6; -.
DR SMR; A6NDR6; -.
DR IntAct; A6NDR6; 2.
DR BioMuta; HGNC:7002; -.
DR jPOST; A6NDR6; -.
DR MassIVE; A6NDR6; -.
DR MaxQB; A6NDR6; -.
DR PeptideAtlas; A6NDR6; -.
DR ProteomicsDB; 923; -.
DR Pumba; A6NDR6; -.
DR AGR; HGNC:7002; -.
DR GeneCards; MEIS3P1; -.
DR HGNC; HGNC:7002; MEIS3P1.
DR neXtProt; NX_A6NDR6; -.
DR InParanoid; A6NDR6; -.
DR PathwayCommons; A6NDR6; -.
DR Pharos; A6NDR6; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; A6NDR6; Protein.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR GO; GO:0009880; P:embryonic pattern specification; IBA:GO_Central.
DR GO; GO:0001654; P:eye development; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR032453; PKNOX/Meis_N.
DR PANTHER; PTHR11850:SF190; HOMEOBOX PROTEIN MEIS3-RELATED; 1.
DR PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF16493; Meis_PKNOX_N; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 5: Uncertain;
KW DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..274
FT /note="Putative homeobox protein Meis3-like 1"
FT /id="PRO_0000347055"
FT DOMAIN 12..65
FT /note="MEIS N-terminal"
FT /evidence="ECO:0000255"
FT DNA_BIND 161..223
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 108..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 274 AA; 30204 MW; 62E2805A71CBDF09 CRC64;
MGPELGWGHP RGGDVCSSDS FNEDNTAFAK QVRSERPFFS SNPELDNLMI QAIQVLRFHL
LELEKGKMPI DLVIEDRDGG CREDFEDYPA SCPSLPDQNN IWIRDHEDSG SVHLGTPGPS
SGGLASQSGD NSSDQGVGLD TSVASPSSGG EDEDLDQEPR RNKKRGIFPK VATNIMRAWL
FQHLSHPYPS EEQKKQLAQD TGLTILQVNN WFINARRRIV QPMIDQSNRT GQGAAFSPEG
QPIGGYTETE PHVAFRAPAS VGMSLNSEGE WHYL
//
