ID A6NJ28_HUMAN Unreviewed; 148 AA.
AC A6NJ28;
DT 24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 122.
DE SubName: Full=RAS guanyl releasing protein 2 {ECO:0000313|Ensembl:ENSP00000366706.3};
GN Name=RASGRP2 {ECO:0000313|Ensembl:ENSP00000366706.3};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000366706.3, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000366706.3, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000366706.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AP001462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR IntAct; A6NJ28; 1.
DR ProteomicsDB; 1305; -.
DR Antibodypedia; 2786; 150 antibodies from 27 providers.
DR Ensembl; ENST00000377486.7; ENSP00000366706.3; ENSG00000068831.19.
DR Ensembl; ENST00000377487.5; ENSP00000366707.1; ENSG00000068831.19.
DR Ensembl; ENST00000377489.5; ENSP00000366709.1; ENSG00000068831.19.
DR Ensembl; ENST00000394430.5; ENSP00000377951.1; ENSG00000068831.19.
DR UCSC; uc001oaw.2; human.
DR HGNC; HGNC:9879; RASGRP2.
DR VEuPathDB; HostDB:ENSG00000068831; -.
DR GeneTree; ENSGT00940000160483; -.
DR Proteomes; UP000005640; Chromosome 11.
DR Bgee; ENSG00000068831; Expressed in granulocyte and 177 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 1: Evidence at protein level;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00135};
KW Proteomics identification {ECO:0007829|EPD:A6NJ28,
KW ECO:0007829|MaxQB:A6NJ28};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 4..126
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
SQ SEQUENCE 148 AA; 16617 MW; A0D3780E651D4D4F CRC64;
MAGTLDLDKG CTVEELLRGC IEAFDDSGKV RDPQLVRMFL MMHPWYIPSS QLAAKLLHIY
QQSRKDNSNS LQVKTCHLVR YWISAFPAEF DLNPELAEQI KELKALLDQE GNRRHSSLID
IDSVCVGGAQ RAGGALSILY HLCLINVC
//
