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Database: UniProt
Entry: A6NLU0
LinkDB: A6NLU0
Original site: A6NLU0 
ID   RFPLA_HUMAN             Reviewed;         287 AA.
AC   A6NLU0;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 3.
DT   29-OCT-2014, entry version 64.
DE   RecName: Full=Ret finger protein-like 4A;
DE   AltName: Full=RING finger protein 210;
GN   Name=RFPL4A; Synonyms=RFPL4, RNF210;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.52 ANGSTROMS) OF 94-287.
RX   PubMed=16364311; DOI=10.1016/j.febslet.2005.11.076;
RA   Gruetter C., Briand C., Capitani G., Mittl P.R.E., Papin S.,
RA   Tschopp J., Gruetter M.G.;
RT   "Structure of the PRYSPRY-domain: implications for autoinflammatory
RT   diseases.";
RL   FEBS Lett. 580:99-106(2006).
CC   -!- SIMILARITY: Contains 1 B30.2/SPRY domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00548}.
CC   -!- SIMILARITY: Contains 1 RING-type zinc finger.
CC       {ECO:0000255|PROSITE-ProRule:PRU00175}.
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DR   EMBL; AC008749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS46201.1; -.
DR   RefSeq; NP_001138486.1; NM_001145014.1.
DR   UniGene; Hs.631553; -.
DR   PDB; 2FBE; X-ray; 2.52 A; A/B/C/D=94-287.
DR   PDBsum; 2FBE; -.
DR   ProteinModelPortal; A6NLU0; -.
DR   SMR; A6NLU0; 56-285.
DR   BioGrid; 131211; 4.
DR   STRING; 9606.ENSP00000345151; -.
DR   PhosphoSite; A6NLU0; -.
DR   MaxQB; A6NLU0; -.
DR   PaxDb; A6NLU0; -.
DR   PRIDE; A6NLU0; -.
DR   Ensembl; ENST00000434937; ENSP00000392936; ENSG00000223638.
DR   GeneID; 342931; -.
DR   KEGG; hsa:342931; -.
DR   UCSC; uc010yge.2; human.
DR   CTD; 342931; -.
DR   GeneCards; GC19P056270; -.
DR   HGNC; HGNC:16449; RFPL4A.
DR   HPA; HPA046368; -.
DR   MIM; 612601; gene.
DR   neXtProt; NX_A6NLU0; -.
DR   PharmGKB; PA162401186; -.
DR   eggNOG; NOG313937; -.
DR   GeneTree; ENSGT00760000118993; -.
DR   HOGENOM; HOG000230861; -.
DR   HOVERGEN; HBG061854; -.
DR   InParanoid; A6NLU0; -.
DR   OMA; ICKESIN; -.
DR   OrthoDB; EOG7CVPZS; -.
DR   PhylomeDB; A6NLU0; -.
DR   TreeFam; TF317532; -.
DR   EvolutionaryTrace; A6NLU0; -.
DR   GenomeRNAi; 342931; -.
DR   NextBio; 98405; -.
DR   PRO; PR:A6NLU0; -.
DR   Bgee; A6NLU0; -.
DR   CleanEx; HS_RFPL4A; -.
DR   Genevestigator; A6NLU0; -.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR003879; Butyrophylin.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR006574; PRY.
DR   InterPro; IPR022723; RDM_domain_RFPL.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF13765; PRY; 1.
DR   Pfam; PF11002; RDM; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   PRINTS; PR01407; BUTYPHLNCDUF.
DR   SMART; SM00589; PRY; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Metal-binding; Reference proteome;
KW   Zinc; Zinc-finger.
FT   CHAIN         1    287       Ret finger protein-like 4A.
FT                                /FTId=PRO_0000300811.
FT   DOMAIN       78    276       B30.2/SPRY. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00548}.
FT   ZN_FING      11     53       RING-type; degenerate.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00175}.
FT   TURN        102    104       {ECO:0000244|PDB:2FBE}.
FT   STRAND      109    111       {ECO:0000244|PDB:2FBE}.
FT   STRAND      115    120       {ECO:0000244|PDB:2FBE}.
FT   STRAND      135    137       {ECO:0000244|PDB:2FBE}.
FT   STRAND      139    143       {ECO:0000244|PDB:2FBE}.
FT   STRAND      146    156       {ECO:0000244|PDB:2FBE}.
FT   STRAND      161    169       {ECO:0000244|PDB:2FBE}.
FT   TURN        182    185       {ECO:0000244|PDB:2FBE}.
FT   STRAND      186    192       {ECO:0000244|PDB:2FBE}.
FT   TURN        193    195       {ECO:0000244|PDB:2FBE}.
FT   STRAND      196    199       {ECO:0000244|PDB:2FBE}.
FT   STRAND      201    203       {ECO:0000244|PDB:2FBE}.
FT   STRAND      205    207       {ECO:0000244|PDB:2FBE}.
FT   STRAND      215    221       {ECO:0000244|PDB:2FBE}.
FT   TURN        222    225       {ECO:0000244|PDB:2FBE}.
FT   STRAND      226    231       {ECO:0000244|PDB:2FBE}.
FT   TURN        232    234       {ECO:0000244|PDB:2FBE}.
FT   STRAND      237    241       {ECO:0000244|PDB:2FBE}.
FT   STRAND      250    257       {ECO:0000244|PDB:2FBE}.
FT   STRAND      259    262       {ECO:0000244|PDB:2FBE}.
FT   STRAND      267    269       {ECO:0000244|PDB:2FBE}.
SQ   SEQUENCE   287 AA;  32238 MW;  53B423A78E3F3E41 CRC64;
     MAEHFKQIIR CPVCLKDLEE AVQLKCGYAC CLQCLNSLQK EPDGEGLLCR FCSVVSQKDD
     IKPKYKLRAL VSIIKELEPK LKSVLTMNPR MRKFQVDMTF DVDTANNYLI ISEDLRSFRS
     GDLSQNRKEQ AERFDTALCV LGTPRFTSGR HYWEVDVGTS QVWDVGVCKE SVNRQGKIVL
     SSEHGFLTVG CREGKVFAAS TVPMTPLWVS PQLHRVGIFL DVGMRSIAFY NVSDGCHIYT
     FIEIPVCEPW RPFFAHKRGS QDDQSILSIC SVINPSAASA PVSSEGK
//
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