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Database: UniProt
Entry: A6NLU0
LinkDB: A6NLU0
Original site: A6NLU0 
ID   RFPLA_HUMAN             Reviewed;         287 AA.
AC   A6NLU0;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 3.
DT   16-APR-2014, entry version 59.
DE   RecName: Full=Ret finger protein-like 4A;
DE   AltName: Full=RING finger protein 210;
GN   Name=RFPL4A; Synonyms=RFPL4, RNF210;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.52 ANGSTROMS) OF 94-287.
RX   PubMed=16364311; DOI=10.1016/j.febslet.2005.11.076;
RA   Gruetter C., Briand C., Capitani G., Mittl P.R.E., Papin S.,
RA   Tschopp J., Gruetter M.G.;
RT   "Structure of the PRYSPRY-domain: implications for autoinflammatory
RT   diseases.";
RL   FEBS Lett. 580:99-106(2006).
CC   -!- SIMILARITY: Contains 1 B30.2/SPRY domain.
CC   -!- SIMILARITY: Contains 1 RING-type zinc finger.
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DR   EMBL; AC008749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001138486.1; NM_001145014.1.
DR   UniGene; Hs.631553; -.
DR   PDB; 2FBE; X-ray; 2.52 A; A/B/C/D=94-287.
DR   PDBsum; 2FBE; -.
DR   ProteinModelPortal; A6NLU0; -.
DR   SMR; A6NLU0; 1-285.
DR   BioGrid; 131211; 2.
DR   STRING; 9606.ENSP00000345151; -.
DR   PhosphoSite; A6NLU0; -.
DR   PaxDb; A6NLU0; -.
DR   PRIDE; A6NLU0; -.
DR   Ensembl; ENST00000434937; ENSP00000392936; ENSG00000223638.
DR   GeneID; 342931; -.
DR   KEGG; hsa:342931; -.
DR   UCSC; uc010yge.2; human.
DR   CTD; 342931; -.
DR   GeneCards; GC19P056270; -.
DR   HGNC; HGNC:16449; RFPL4A.
DR   HPA; HPA046368; -.
DR   MIM; 612601; gene.
DR   neXtProt; NX_A6NLU0; -.
DR   PharmGKB; PA162401186; -.
DR   eggNOG; NOG313937; -.
DR   HOGENOM; HOG000230861; -.
DR   HOVERGEN; HBG061854; -.
DR   InParanoid; A6NLU0; -.
DR   OMA; ICKESIN; -.
DR   OrthoDB; EOG7CVPZS; -.
DR   PhylomeDB; A6NLU0; -.
DR   TreeFam; TF317532; -.
DR   EvolutionaryTrace; A6NLU0; -.
DR   GenomeRNAi; 342931; -.
DR   NextBio; 98405; -.
DR   PRO; PR:A6NLU0; -.
DR   Bgee; A6NLU0; -.
DR   CleanEx; HS_RFPL4A; -.
DR   Genevestigator; A6NLU0; -.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR003879; Butyrophylin.
DR   InterPro; IPR008985; ConA-like_lec_gl_sf.
DR   InterPro; IPR006574; PRY.
DR   InterPro; IPR022723; RDM_domain_RFPL.
DR   InterPro; IPR018355; SPla/RYanodine_receptor_subgr.
DR   InterPro; IPR003877; SPRY_rcpt.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF13765; PRY; 1.
DR   Pfam; PF11002; RDM; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   PRINTS; PR01407; BUTYPHLNCDUF.
DR   SMART; SM00589; PRY; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Metal-binding; Reference proteome;
KW   Zinc; Zinc-finger.
FT   CHAIN         1    287       Ret finger protein-like 4A.
FT                                /FTId=PRO_0000300811.
FT   DOMAIN       78    276       B30.2/SPRY.
FT   ZN_FING      11     53       RING-type; degenerate.
FT   TURN        102    104
FT   STRAND      109    111
FT   STRAND      115    120
FT   STRAND      135    137
FT   STRAND      139    143
FT   STRAND      146    156
FT   STRAND      161    169
FT   TURN        182    185
FT   STRAND      186    192
FT   TURN        193    195
FT   STRAND      196    199
FT   STRAND      201    203
FT   STRAND      205    207
FT   STRAND      215    221
FT   TURN        222    225
FT   STRAND      226    231
FT   TURN        232    234
FT   STRAND      237    241
FT   STRAND      250    257
FT   STRAND      259    262
FT   STRAND      267    269
SQ   SEQUENCE   287 AA;  32238 MW;  53B423A78E3F3E41 CRC64;
     MAEHFKQIIR CPVCLKDLEE AVQLKCGYAC CLQCLNSLQK EPDGEGLLCR FCSVVSQKDD
     IKPKYKLRAL VSIIKELEPK LKSVLTMNPR MRKFQVDMTF DVDTANNYLI ISEDLRSFRS
     GDLSQNRKEQ AERFDTALCV LGTPRFTSGR HYWEVDVGTS QVWDVGVCKE SVNRQGKIVL
     SSEHGFLTVG CREGKVFAAS TVPMTPLWVS PQLHRVGIFL DVGMRSIAFY NVSDGCHIYT
     FIEIPVCEPW RPFFAHKRGS QDDQSILSIC SVINPSAASA PVSSEGK
//
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