ID A6Q209_NITSB Unreviewed; 549 AA.
AC A6Q209;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=von Willebrand factor type A domain protein {ECO:0000313|EMBL:BAF69518.1};
GN OrderedLocusNames=NIS_0404 {ECO:0000313|EMBL:BAF69518.1};
OS Nitratiruptor sp. (strain SB155-2).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Nautiliales;
OC Nitratiruptoraceae; Nitratiruptor.
OX NCBI_TaxID=387092 {ECO:0000313|EMBL:BAF69518.1, ECO:0000313|Proteomes:UP000001118};
RN [1] {ECO:0000313|EMBL:BAF69518.1, ECO:0000313|Proteomes:UP000001118}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB155-2 {ECO:0000313|EMBL:BAF69518.1,
RC ECO:0000313|Proteomes:UP000001118};
RX PubMed=17615243; DOI=10.1073/pnas.0700687104;
RA Nakagawa S., Takaki Y., Shimamura S., Reysenbach A.-L., Takai K.,
RA Horikoshi K.;
RT "Deep-sea vent epsilon-proteobacterial genomes provide insights into
RT emergence of pathogens.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:12146-12150(2007).
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DR EMBL; AP009178; BAF69518.1; -; Genomic_DNA.
DR RefSeq; WP_012081781.1; NC_009662.1.
DR AlphaFoldDB; A6Q209; -.
DR STRING; 387092.NIS_0404; -.
DR KEGG; nis:NIS_0404; -.
DR eggNOG; COG0457; Bacteria.
DR eggNOG; COG2304; Bacteria.
DR HOGENOM; CLU_032390_0_0_7; -.
DR InParanoid; A6Q209; -.
DR OrthoDB; 9807628at2; -.
DR Proteomes; UP000001118; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR22550; SPORE GERMINATION PROTEIN; 1.
DR PANTHER; PTHR22550:SF14; VWFA DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00515; TPR_1; 1.
DR Pfam; PF13432; TPR_16; 1.
DR Pfam; PF13519; VWA_2; 1.
DR SMART; SM00028; TPR; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS50293; TPR_REGION; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001118};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 54..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 86..292
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 369..402
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 404..437
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 450..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..524
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 549 AA; 62800 MW; E9F2F79C81259207 CRC64;
MKFLSFEFIP LMLLPSIVLL YLVLTNKSMV ERIFEESVLS KLRIDQGLSK KMRLTLLFMA
LFAMILAMAR PVYQKGVVQV ESLSANVGIA LDISNSMKAT DYYPDRLQFA KKKIEEFIKA
SKNLNIALLA FADEAYIVSP PSSDKEALLY MLKHLDTESL ALQGTNFLAA LMSADMLLGK
EGQKSVVLFT DGGNKEDFSK EIAFAKKRGI QVHIIGIGTQ KGAPIPTKNG YMQDAKGNIV
ITKLNVHIAE LATKTGGIFI QASYGNQDIQ KILAHLESLA KTHHIEKIVD QVEFYPYLLA
LAFLFLFMAF FTIPSKQMTL LAVLMIGLKL HAGLTDFKLI KQAKEAYDRG AYEVAAQKFK
EIAEVKGSAQ SYFDAGNALY KAKKYKEAFQ YYAKVQTEDK ELEFRKLHNM GNCYFQLQNY
QKAIEMYEKA LKLKNDPDTK YNLELAKKML QKKRKQQNKK NDQKQQNQKK SPQQKKSKNK
QNSKQEKNQK NQKSQNKQKQ KSKQMRKNVP ISDREEKKWI KQIEKNPLKT FLYKAPLKIK
KEGTDENPW
//
