ID A6QLK9_BOVIN Unreviewed; 305 AA.
AC A6QLK9; F6R7C3;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=Peroxisome biogenesis factor 2 {ECO:0000256|ARBA:ARBA00034543};
DE EC=2.3.2.36 {ECO:0000256|ARBA:ARBA00034523};
DE AltName: Full=Peroxin-2 {ECO:0000256|ARBA:ARBA00032511};
GN Name=PEX2 {ECO:0000313|Ensembl:ENSBTAP00000005062.5,
GN ECO:0000313|VGNC:VGNC:53872};
GN Synonyms=PXMP3 {ECO:0000313|EMBL:AAI48002.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI48002.1};
RN [1] {ECO:0000313|EMBL:AAI48002.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=L1 Hereford {ECO:0000313|EMBL:AAI48002.1};
RC TISSUE=Basal ganglia {ECO:0000313|EMBL:AAI48002.1};
RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA Holt R., Jones S.J., Marra M.A.;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000005062.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000005062.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSBTAP00000005062.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000005062.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.; EC=2.3.2.36;
CC Evidence={ECO:0000256|ARBA:ARBA00034438};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Peroxisome
CC membrane {ECO:0000256|ARBA:ARBA00004585}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004585}.
CC -!- SIMILARITY: Belongs to the pex2/pex10/pex12 family.
CC {ECO:0000256|ARBA:ARBA00008704}.
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DR EMBL; BC148001; AAI48002.1; -; mRNA.
DR RefSeq; NP_001093818.1; NM_001100348.1.
DR RefSeq; XP_005215572.1; XM_005215515.3.
DR STRING; 9913.ENSBTAP00000005062; -.
DR PaxDb; 9913-ENSBTAP00000005062; -.
DR Ensembl; ENSBTAT00000005062.5; ENSBTAP00000005062.5; ENSBTAG00000003885.5.
DR Ensembl; ENSBTAT00000070745.1; ENSBTAP00000060608.1; ENSBTAG00000003885.5.
DR GeneID; 512677; -.
DR KEGG; bta:512677; -.
DR CTD; 5828; -.
DR VEuPathDB; HostDB:ENSBTAG00000003885; -.
DR VGNC; VGNC:53872; PEX2.
DR eggNOG; KOG2879; Eukaryota.
DR GeneTree; ENSGT00390000001846; -.
DR HOGENOM; CLU_024591_3_1_1; -.
DR OMA; YLICTVG; -.
DR OrthoDB; 64567at2759; -.
DR TreeFam; TF105312; -.
DR Reactome; R-BTA-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
DR Reactome; R-BTA-9033241; Peroxisomal protein import.
DR Reactome; R-BTA-9603798; Class I peroxisomal membrane protein import.
DR Proteomes; UP000009136; Chromosome 14.
DR Bgee; ENSBTAG00000003885; Expressed in oocyte and 104 other cell types or tissues.
DR GO; GO:0016593; C:Cdc73/Paf1 complex; IBA:GO_Central.
DR GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IBA:GO_Central.
DR GO; GO:0007031; P:peroxisome organization; IBA:GO_Central.
DR GO; GO:0016558; P:protein import into peroxisome matrix; IEA:InterPro.
DR GO; GO:0000038; P:very long-chain fatty acid metabolic process; IBA:GO_Central.
DR CDD; cd16526; RING-HC_PEX2; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR025654; PEX2/10.
DR InterPro; IPR006845; Pex_N.
DR InterPro; IPR045859; RING-HC_PEX2.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR48178; PEROXISOME BIOGENESIS FACTOR 2; 1.
DR PANTHER; PTHR48178:SF1; PEROXISOME BIOGENESIS FACTOR 2; 1.
DR Pfam; PF04757; Pex2_Pex12; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 244..283
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 305 AA; 34819 MW; F49B5F665AA45E6A CRC64;
MASGDENAER TNRVLRISQL DALELNKALE QLVWSQFTQC FHGFKPGLLA RFEPEVKAFL
WLFLWRFTIY SKNATVGQSV LNIQYQNDLS PNLSYQPPSR NQKLWYAVCT IGGKWLEERC
YDLFRNRHIA SFRKAKQCMN LVVGLLKLGG LINFLIFLQR GKFATLTERL LGIHSVFHKP
QSVREVGFEY MNRELLWHGF AEFLIFLLPL INVQKLRAKL SSWCVPLTGA PGSNSTLATS
GRQCSLCGEW PTMPHTVGCE HVFCYYCVKS SFLFDMSFTC PKCGTEVHSL QPLKSGIEMA
EVSVP
//
