ID A6QQ46_BOVIN Unreviewed; 428 AA.
AC A6QQ46;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 110.
DE SubName: Full=LTBR protein {ECO:0000313|EMBL:AAI49640.1};
DE SubName: Full=Lymphotoxin beta receptor {ECO:0000313|Ensembl:ENSBTAP00000020355.4};
GN Name=LTBR {ECO:0000313|EMBL:AAI49640.1,
GN ECO:0000313|Ensembl:ENSBTAP00000020355.4,
GN ECO:0000313|VGNC:VGNC:31075};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI49640.1};
RN [1] {ECO:0000313|EMBL:AAI49640.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Crossbred x Angus {ECO:0000313|EMBL:AAI49640.1};
RC TISSUE=Ileum {ECO:0000313|EMBL:AAI49640.1};
RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA Holt R., Jones S.J., Marra M.A.;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000020355.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000020355.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSBTAP00000020355.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000020355.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; BC149639; AAI49640.1; -; mRNA.
DR RefSeq; NP_001096698.1; NM_001103228.2.
DR STRING; 9913.ENSBTAP00000020355; -.
DR PaxDb; 9913-ENSBTAP00000020355; -.
DR Ensembl; ENSBTAT00000020355.5; ENSBTAP00000020355.4; ENSBTAG00000015312.5.
DR GeneID; 504653; -.
DR KEGG; bta:504653; -.
DR CTD; 4055; -.
DR VEuPathDB; HostDB:ENSBTAG00000015312; -.
DR VGNC; VGNC:31075; LTBR.
DR eggNOG; ENOG502S4WF; Eukaryota.
DR GeneTree; ENSGT00940000162178; -.
DR HOGENOM; CLU_052594_0_0_1; -.
DR OMA; NNCVPCK; -.
DR OrthoDB; 5320298at2759; -.
DR TreeFam; TF331157; -.
DR Reactome; R-BTA-5668541; TNFR2 non-canonical NF-kB pathway.
DR Reactome; R-BTA-5676594; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000015312; Expressed in vas deferens and 104 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0048534; P:hematopoietic or lymphoid organ development; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR CDD; cd10578; TNFRSF3; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR017349; TNFR_3_LTBR.
DR InterPro; IPR033997; TNFRSF3_N.
DR PANTHER; PTHR47607; TUMOR NECROSIS FACTOR RECEPTOR SUBFAMILY MEMBER 3; 1.
DR PANTHER; PTHR47607:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 3; 1.
DR Pfam; PF00020; TNFR_c6; 3.
DR PRINTS; PR01920; TNFACTORR3.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 3.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..428
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014083980"
FT TRANSMEM 230..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..87
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 49..87
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 89..131
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 89..131
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REPEAT 176..217
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 176..217
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REGION 203..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 377..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..401
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 50..65
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 66..79
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 69..87
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 90..105
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 177..192
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 428 AA; 46724 MW; 25AEB85B8557ACF8 CRC64;
MRLLWATSHR GLAWGLLILG VWGLLAASQP QLEREEPVQG LPYHTENQSC GDQEKEYYES
KLRLCCSRCP PGTHISTKCS RRQNTVCATC PEKSYNEHWN HLSFCQLCRP CDKMLGFVEL
TPCTSNRKAQ CHCQPGMYCV FWNSECEHCE PLSDCPPGTE AELKDEVIEA NSNCVPCKAG
HFQNTSSPTA RCRPHTRCED QGLVEEAPGT PQSDTSCRNP QEPPDMPGTM LVLAILLPLV
SFLLLTTVFV YTWKSHPSLC RKLGSLLKRH PEGEESNPAD GNWEPPRFNT HVPDLVKPLL
PAPGDLALAS GGVPANPGLE EEVLQQQSPL SQARDLDAEP PEQGQVAPGT NGIHVTGGSV
TVTGNIYIYN GPVLGGARGP GDPPAPPEPP YPIPEEGAPR PPGLSMPYQE DGKAWHLAET
ETLGCYAL
//
